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  2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species Endogenous Metabolite
  4. Lycopene

Lycopene  (Synonyms: 番茄紅素)

目錄號: HY-N0287 純度: 98.44%
COA 產(chǎn)品使用指南 技術(shù)支持

Lycopene是番茄，番茄產(chǎn)品和其他紅色水果和蔬菜中天然存在的類胡蘿卜素; 具有抗氧化作用。

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Lycopene Chemical Structure

Lycopene Chemical Structure

CAS No. : 502-65-8

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥660
In-stock
10 mg ￥990
In-stock
25 mg ￥1600
In-stock
50 mg ￥2400
In-stock
100 mg   詢價  
200 mg   詢價  

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Customer Review

Other Forms of Lycopene:

  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects.

IC50 & Target

Human Endogenous Metabolite

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
Platelet IC50
5.8 μM
Compound: Lycopene
Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
[PMID: 32463237]
Platelet IC50
6.2 μM
Compound: Lycopene
Inhibition of ADP-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
Inhibition of ADP-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
[PMID: 32463237]
Platelet IC50
6.8 μM
Compound: Lycopene
Inhibition of arachidonic acid-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
Inhibition of arachidonic acid-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
[PMID: 32463237]
體外研究
(In Vitro)

從飲食中攝取足夠的 Lycopene 對于從其促進健康的作用中獲益是必要的，因為人類無法從頭合成 Lycopene。Lycopene 在 1.25 μM 的生理相關(guān)濃度下顯著抑制前列腺和乳腺癌細胞的生長，并且還會導(dǎo)致細胞中 kappa B 磷酸化抑制劑減少 30-40%[1]。
增加 Lycopene 的攝入量，Lycopene 是西紅柿中的一種主要類胡蘿卜素，作為全反式異構(gòu)體食用可減弱酒精誘導(dǎo)的 2E1 細胞凋亡，并降低患前列腺癌、肺癌和消化道癌的風(fēng)險。Lycopene 作為單線態(tài)分子氧和過氧自由基清除劑在光氧化過程中起到保護作用，并且可以與其他抗氧化劑協(xié)同作用[2]。
作為類胡蘿卜素的 Lycopene 可以通過三種不同的機制與活性氧 (ROS) 類型發(fā)生反應(yīng)：I) 通過電子轉(zhuǎn)移，II) 通過氫原子轉(zhuǎn)移或 III) 通過加合物形成。Lycopene 主要通過物理淬滅使單線態(tài)氧失活[3]。
Lycopene 通過抑制 PKC 通路中產(chǎn)生的 NADPH 氧化酶來降低 SK-Hep-1 細胞中 ROS 的產(chǎn)生[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Lycopene 是人體血漿中最主要的類胡蘿卜素，半衰期約為 2-3 天[2]。
Lycopene 或加工過的西紅柿可能會導(dǎo)致血管壁內(nèi)膜中層厚度減少[3]。
Lycopene 對大鼠腎上腺皮質(zhì)中 ATZ 誘導(dǎo)的毒性發(fā)揮保護作用。這些作用可能歸因于 Lycopene 的抗氧化特性及其激活 Nrf2/HO-1 通路的能力[4]。
Lycopene 作為抗氧化劑改善肝毒性，降低 GSSG 并調(diào)節(jié) tGSH 和 CAT 水平，減少氧化損傷[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

536.87

Formula

C40H56
CAS 號
性狀

固體

顏色

Purple to red

中文名稱

番茄紅素；茄紅素；西紅柿紅素
結(jié)構(gòu)分類
初始來源
運輸條件

Shipping with dry ice.
儲存方式

-80°C, protect from light, stored under nitrogen
溶解性數(shù)據(jù)
細胞實驗： 

THF 中的溶解度 : 5 mg/mL (9.31 mM; 超聲助溶)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.8626 mL 9.3132 mL 18.6265 mL
5 mM 0.3725 mL 1.8626 mL 3.7253 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months (protect from light, stored under nitrogen)。-80°C 儲存時，請在6個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 98.44%

參考文獻
Cell Assay
[1]

PC3 cells and MDA-MB-231 cells are treated with (0, 0.5, 1.25, 2.5 and 5 μM) lycopene for 48 h. Cell survival/growth is measured using the colorimetric MTS assay method. MTS-PMS complex (20 μL) is added to each well. The catalytic activity of viable cells results in formazan dye production, which is then quantified. Cells are incubated with the dye for 1 h, followed by absorbance reading at 492 nm on a spectrophotometer[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[4]

Rats: Lycopene is dissolved in corn oil. 35 adult male albino rats are randomized into five equal groups: untreated control, vehicle control (receives 0.5 mL corn oil/day), lycopene (10 mg/kg b.w./day), ATZ (dissolved in 0.5 mL corn oil 300 mg/kg b.w./day), and ATZ + lycopene. All treatments are given by oral gavage for 4 weeks[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months (protect from light, stored under nitrogen)。-80°C 儲存時，請在6個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
THF 1 mM 1.8626 mL 9.3132 mL 18.6265 mL 46.5662 mL
5 mM 0.3725 mL 1.8626 mL 3.7253 mL 9.3132 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Lycopene
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HY-N0287
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