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  2. Metabolic Enzyme/Protease
  3. MMP Endogenous Metabolite
  4. Stigmasterol

Stigmasterol  (Synonyms: 豆甾醇)

目錄號: HY-N0131 純度: ≥98.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Stigmasterol (Stigmasterin) 是一種植物性甾醇，不僅具有降低膽固醇的活性，并且在風(fēng)濕性疾病的研究中被評價為抗硬化因子。

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Stigmasterol Chemical Structure

Stigmasterol Chemical Structure

CAS No. : 83-48-7

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規(guī)格 價格 是否有貨 數(shù)量
100 mg ￥500
In-stock
200 mg   詢價  
500 mg   詢價  

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Customer Review

Other Forms of Stigmasterol:

  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.

IC50 & Target

Human Endogenous Metabolite

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
10.36 μM
Compound: SS
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 24 hrs by MTT assay
10.1039/C6MD00178E
A549 IC50
98.2 μM
Compound: 4, stigmasterol
Cytotoxicity against human A549 cells after 1 hr by MTT assay
Cytotoxicity against human A549 cells after 1 hr by MTT assay
[PMID: 18343122]
Calu-1 IC50
> 100 μM
Compound: 7
Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
DU-145 IC50
22.73 μM
Compound: 3
Cytotoxicity against human DU145 cells after 24 hrs by MTT assay
Cytotoxicity against human DU145 cells after 24 hrs by MTT assay
[PMID: 22687747]
HeLa IC50
> 100 μM
Compound: 7
Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
HeLa IC50
> 50 μM
Compound: 3
Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
[PMID: 19388709]
HeLa IC50
12.21 μM
Compound: SS
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 24 hrs by MTT assay
10.1039/C6MD00178E
J774 IC50
> 242.3 μM
Compound: 12
Cytotoxicity against mouse J774 cells by alamar blue assay
Cytotoxicity against mouse J774 cells by alamar blue assay
[PMID: 17637068]
K562 IC50
> 100 μM
Compound: 7
Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
K562 IC50
11.14 μM
Compound: 3
Cytotoxicity against human K562 cells after 24 hrs by MTT assay
Cytotoxicity against human K562 cells after 24 hrs by MTT assay
[PMID: 22687747]
KB ED50
> 4 μg/mL
Compound: stigmasterol
Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
[PMID: 9644061]
MCF7 IC50
21.43 μM
Compound: 3
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
[PMID: 22687747]
MDA-MB-231 IC50
564 μM
Compound: 8
Cytotoxicity against human MDA-MB-231 cells after 3 days by Celltiter-Glo assay
Cytotoxicity against human MDA-MB-231 cells after 3 days by Celltiter-Glo assay
[PMID: 28945373]
P388D1 IC50
> 50 μM
Compound: 3
Cytotoxicity against mouse P388D1 cells by MTT assay
Cytotoxicity against mouse P388D1 cells by MTT assay
[PMID: 19388709]
PC-3 IC50
18.28 μM
Compound: 3
Cytotoxicity against human PC3 cells after 24 hrs by MTT assay
Cytotoxicity against human PC3 cells after 24 hrs by MTT assay
[PMID: 22687747]
Raji IC50
> 100 μM
Compound: 7
Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
Vero IC50
> 100 μM
Compound: 7
Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
WISH IC50
> 100 μM
Compound: 7
Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
體外研究
(In Vitro)

Stigmasterol 與 IL-1beta 處理的細胞預(yù)孵育顯示人和小鼠中的 MMP-3 mRNA、小鼠中的 MMP-3 蛋白、小鼠和人中的 MMP-13 mRNA、人中的 ADAMTS-4 mRNA、人中的 PGE2 蛋白顯著減少和鼠標。Stigmasterol 還能夠抵消 IL-1beta 誘導(dǎo)的 NF-κB 通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

412.69

Formula

C29H48O
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

豆甾醇
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗： 

Acetone 中的溶解度 : 2 mg/mL (4.85 mM; 超聲助溶 (<60°C))

DMF 中的溶解度 : 1 mg/mL (2.42 mM; 超聲助溶 (<60°C))

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

1M NaOH 中的溶解度 : < 1 mg/mL (insoluble)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.4231 mL 12.1156 mL 24.2313 mL
5 mM --- --- ---
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑： Corn Oil

    Solubility: 3.12 mg/mL (7.56 mM); 澄清溶液; 超聲助溶 (<50°C)

  • 方案 二

    請依序添加每種溶劑： 15% Cremophor EL    85% Saline

    Solubility: 10 mg/mL (24.23 mM); 懸濁液; 超聲助溶

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻
Cell Assay
[1]

A model of newborn mouse chondrocytes and human osteoarthritis (OA) chondrocytes are used in primary culture stimulated with or without IL-1β (10 ng/mL), for 18 h. Cells are pre-incubated with Stigmasterol (20 mg/mL) for 48 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMF / Acetone 1 mM 2.4231 mL 12.1156 mL 24.2313 mL 60.5782 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Stigmasterol
目錄號：
HY-N0131
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