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  2. 天然產(chǎn)物
  3. 疾病研究領(lǐng)域 植物 生物堿
  4. 蕓香科 癌癥 哌啶類(lèi)生物堿 吲哚類(lèi)生物堿
  5. 吳茱萸
  6. Evodiamine

Evodiamine  (Synonyms: 吳茱萸堿; (+)-Evodiamine; d-Evodiamine)

目錄號(hào): HY-N0114 純度: 99.97%
COA 產(chǎn)品使用指南

Evodiamine是從吳茱萸的果實(shí)中分離的生物堿, 具有多種生物活性，比如抗炎，抗肥胖和抗腫瘤。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Evodiamine Chemical Structure

Evodiamine Chemical Structure

CAS No. : 518-17-2

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3.  試用裝只面向終端客戶。

規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥385
In-stock
50 mg ￥350
In-stock
100 mg ￥550
In-stock
250 mg ￥950
In-stock
500 mg   詢(xún)價(jià)  
1 g   詢(xún)價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of Evodiamine:

    Evodiamine purchased from MCE. Usage Cited in: Chem Biol Drug Des. 2023 Mar 9.  [Abstract]

    Evodiamine (EVO; 1.25, 2.5, 5 μM; 48h) decreases the SKOV3 cell viability in a dose-dependent manner.

    • 生物活性

    • 實(shí)驗(yàn)參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A549 IC50
    > 200 μM
    Compound: 1
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    		[PMID: 31880942]
    HCT-116 IC50
    > 200 μM
    Compound: 1
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    		[PMID: 31880942]
    MCF7 IC50
    5.4 μM
    Compound: 6
    Antiproliferative activity against human MCF7 cells after 48 to 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 to 72 hrs by MTT assay
    		10.1039/C6MD00170J
    MDA-MB-435 IC50
    22.1 μM
    Compound: 1
    Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
    		[PMID: 31880942]
    MSTO-211H IC50
    0.54 μM
    Compound: 6
    Antiproliferative activity against human MSTO-211H cells after 48 to 72 hrs by MTT assay
    Antiproliferative activity against human MSTO-211H cells after 48 to 72 hrs by MTT assay
    		10.1039/C6MD00170J
    NCI-H460 IC50
    0.26 μM
    Compound: 6
    Antiproliferative activity against human H460 cells after 48 to 72 hrs by MTT assay
    Antiproliferative activity against human H460 cells after 48 to 72 hrs by MTT assay
    		10.1039/C6MD00170J
    NCI-H460 IC50
    2.6 μM
    Compound: 1a
    Cytotoxicity against human H460 cells after 72 hrs by MTT assay
    Cytotoxicity against human H460 cells after 72 hrs by MTT assay
    		[PMID: 24103429]
    體外研究
    (In Vitro)

    Evodiamine 通過(guò)誘導(dǎo)細(xì)胞凋亡對(duì)多種人類(lèi)癌細(xì)胞系表現(xiàn)出細(xì)胞毒性。此外，它是一種天然的多靶點(diǎn)抗腫瘤分子，通過(guò)caspase 依賴(lài)和非依賴(lài)途徑、鞘磷脂途徑、鈣/JNK信號(hào)、PI3K/Akt/caspase 和 Fas-L/NF-κB信號(hào)通路等多種分子機(jī)制發(fā)揮抗腫瘤活性[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Evodiamine 抑制達(dá)泊西汀的代謝。與對(duì)照組相比，Evodiamine 組達(dá)泊西汀的t1/2、AUC (0-∞) 和 Tmax 藥代動(dòng)力學(xué)參數(shù)分別顯著升高 63.3%、44.8% 和50.4%。此外，Evodiamine 顯著降低去甲基達(dá)泊西汀的 t1/2 藥代動(dòng)力學(xué)參數(shù)和 AUC (0-∞)[2]。Evodiamine 抑制皮下 H22 異種移植模型中的腫瘤生長(zhǎng)。Evodiamine 在體內(nèi)減弱 VEGF 誘導(dǎo)的血管生成[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    303.36

    Formula

    C19H17N3O
    CAS 號(hào)
    性狀

    固體

    顏色

    White to yellow

    中文名稱(chēng)

    吳茱萸堿；吳茱萸胺
    結(jié)構(gòu)分類(lèi)
    初始來(lái)源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 10 mg/mL (32.96 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 3.2964 mL 16.4821 mL 32.9641 mL
    5 mM 0.6593 mL 3.2964 mL 6.5928 mL
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物實(shí)驗(yàn)：

    請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

    以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
    ——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶

    • 方案 一

      請(qǐng)依序添加每種溶劑： 10% DMSO    90% Corn Oil

      Solubility: ≥ 1 mg/mL (3.30 mM); 澄清溶液

      此方案可獲得 ≥ 1 mg/mL（飽和度未知）的澄清溶液，此方案實(shí)驗(yàn)周期在半個(gè)月以上的動(dòng)物實(shí)驗(yàn)酌情使用。

      以 1 mL 工作液為例，取 100 μL 10.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL玉米油中，混合均勻。

    動(dòng)物溶解方案計(jì)算器
    請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
    請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過(guò) 2%。
    方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購(gòu)。 ，Tween 80，均可在 MCE 網(wǎng)站選購(gòu)。
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    儲(chǔ)備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
    您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，以下方案僅供參考，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
    動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
    連續(xù)給藥周期超過(guò)半月以上，請(qǐng)謹(jǐn)慎選擇該方案。
    請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 99.97%

    參考文獻(xiàn)
    Cell Assay
    [1]

    Evodiamine is dissolved in DMSO and diluted with appropriate medium before use. The evodiamine-inspired new scaffolds are assayed for growth inhibitory activities toward human cancer cell-lines A549 (lung cancer), MDA-MB-435 (breast cancer) and HCT116 (colon cancer) using the MTT assay. Evodiamine and camptithecin are used as reference drugs[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [2][3]

    Rats: Twelve healthy male Sprague-Dawley rats are randomly divided into 2 groups: the control group (received oral 10 mg/kg dapoxetine alone) and the combination group (10 mg/kg dapoxetine orally co-administered with 100 mg/kg evodiamine). The plasma concentration of dapoxetine and desmethyl dapoxetine are estimated by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), and different pharmacokinetic parameters are calculated[2].

    Mice: A nude mouse xenograft model is established by using 4–6-week-old male BALB/c nude mice. Mice are dosed daily with 20 mg/kg (10 mL/kg) of evodiamine intragastrically, six mice are dosed intraperitoneally with 10 mg/kg of 5-flurouracil (5-FU) twice a week, and six mice are not treated. The tumor volumes are determined by measuring two dimensions, with tumor volume=length×width×width/2. After 2 or 3 weeks of treatment, mice are sacrificed by cervical dislocation under anesthesia with ether, and the tumor tissues are collected[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.2964 mL 16.4821 mL 32.9641 mL 82.4103 mL
    5 mM 0.6593 mL 3.2964 mL 6.5928 mL 16.4821 mL
    10 mM 0.3296 mL 1.6482 mL 3.2964 mL 8.2410 mL
    15 mM 0.2198 mL 1.0988 mL 2.1976 mL 5.4940 mL
    20 mM 0.1648 mL 0.8241 mL 1.6482 mL 4.1205 mL
    25 mM 0.1319 mL 0.6593 mL 1.3186 mL 3.2964 mL
    30 mM 0.1099 mL 0.5494 mL 1.0988 mL 2.7470 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱(chēng)：
    Evodiamine
    目錄號(hào)：
    HY-N0114
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