成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

  2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Anti-infection
  3. HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Bacterial Influenza Virus Endogenous Metabolite
  4. Chlorogenic acid

Chlorogenic acid  (Synonyms: 綠原酸; 3-O-Caffeoylquinic acid; Heriguard; NSC-407296)

目錄號: HY-N0055 純度: 99.35%
COA 產(chǎn)品使用指南 技術(shù)支持

Chlorogenic acid (3-O-Caffeoylquinic acid) 是金銀花中的主要酚類化合物。Chlorogenic acid 是一種具有口服活性的抗氧化活性，抗菌，保肝，心臟保護，抗炎，解熱，神經(jīng)保護，抗肥胖，抗病毒，抗微生物，抗高血壓化合物。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

Chlorogenic acid Chemical Structure

Chlorogenic acid Chemical Structure

CAS No. : 327-97-9

1.  客戶無需承擔相應(yīng)的運輸費用。

2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥550
In-stock
500 mg ￥500
In-stock
1 g   詢價  
5 g   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Chlorogenic acid:

    Chlorogenic acid purchased from MCE. Usage Cited in: Int J Med Microbiol. 2023 Jan 24.

    Chlorogenic acid (CGA; 50 μg/mL; 1 h) inhibits the Klebsiella pneumoniae (Kp)-induced increase in p38 expression levels as well as increases in p-p38/p-38 and p-MK2/MK2 levels, in RLE6TN cells.

    查看 HIF/HIF Prolyl-Hydroxylase 亞型特異性產(chǎn)品:

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻

    生物活性

    Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound[1][2][3].

    細胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    BALB/3T3 IC50
    > 280 μM
    Compound: 14
    Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay
    Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay
    		[PMID: 10096863]
    BMDC IC50
    > 50 μM
    Compound: 4
    Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
    Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
    		[PMID: 25769817]
    BMDC IC50
    > 50 μM
    Compound: 4
    Inhibition of LPS-induced IL-6 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
    Inhibition of LPS-induced IL-6 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
    		[PMID: 25769817]
    BMDC IC50
    > 50 μM
    Compound: 4
    Inhibition of LPS-induced TNF-alpha production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
    Inhibition of LPS-induced TNF-alpha production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
    		[PMID: 25769817]
    BMDM IC50
    86 μM
    Compound: Chlorogenic acid
    Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
    Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
    		[PMID: 31257875]
    HCT-116 IC50
    367 μM
    Compound: chlorogenic acid
    Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
    Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 12880319]
    HeLa IC50
    > 200 μM
    Compound: Chlorogenic acid
    Inhibition of HDAC in human HeLa cells using Boc-Lys(AC)-AMC as substrate after 24 to 48 hrs by spectrofluorometry
    Inhibition of HDAC in human HeLa cells using Boc-Lys(AC)-AMC as substrate after 24 to 48 hrs by spectrofluorometry
    		[PMID: 26996372]
    HeLa IC50
    375 μM
    Compound: 26
    Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay
    Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay
    		[PMID: 19520580]
    SW480 IC50
    353 μM
    Compound: chlorogenic acid
    Cytotoxicity against human SW480 cells after 72 hrs by MTT assay
    Cytotoxicity against human SW480 cells after 72 hrs by MTT assay
    		[PMID: 12880319]
    體外研究
    (In Vitro)

    Chlorogenic acid (10 μM, 16 h) 可降低 CoCl2 誘導(dǎo)的缺氧 A549 細胞中的 HIF-1α 蛋白水平，但不影響 HIF-1α mRNA 水平[1]。
    Chlorogenic acid (10 μM，24 h) 抑制缺氧誘導(dǎo)的 HUVEC 細胞遷移、侵襲和血管內(nèi)皮細胞管形成[1]。
    Chlorogenic acid (25, 50 μM, 24 h) 抑制 Huh7 細胞增殖，并減少入侵和遷移細胞的數(shù)量[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Chlorogenic acid (10 μM, 皮下注射) 通過抑制 AKT 激活來抑制 C57BL/6J 小鼠中 VEGF (200 ng/mL) 誘導(dǎo)的血管生成 (基質(zhì)膠塞測定)[1]。
    Chlorogenic acid (10-100 mg/kg，口服) 對大鼠實驗性反流性食管炎具有保護作用[3]。
    Chlorogenic acid (10 mg/kg，靜脈注射) 可預(yù)防 LPS 中毒的 C57BL/6 小鼠的內(nèi)毒素死亡和誘導(dǎo)的 TNF-α 釋放，并改善 LPS/GalN 攻擊小鼠的急性肝損傷[2] .
    Chlorogenic acid (腹腔注射，25-200 mg/kg) 可抑制接種 Huh7 或 H446 細胞的 NOD/SCID 小鼠的腫瘤生長[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Experimental reflux esophagitis (RE) in rats[1]
    Dosage: 10, 30, 100 mg/kg
    Administration: p.o.
    Result: Reduced esophageal lipid peroxidation (marker: MDA) and increased the reduced glutathione/oxidized glutathione ratio.
    Inhibited the increases in the serum level of TNF-α, and expressions of iNOS and COX-2 protein.
    Animal Model: LPS/GalN-challenged mice[2]
    Dosage: 10 mg/kg
    Administration: i.v.
    Result: Increased survival rates of LPS/GalN-intoxicated mice.
    Inhibited LPS/GalN-induced phosphorylation of NF-κB p65 or c-Jun, without affecting p-IRF3 levels in the liver lobules.
    Clinical Trial
    分子量

    354.31

    Formula

    C16H18O9
    CAS 號
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    綠原酸；3-咖啡?？崴?；咖啡單寧酸；咖啡?？崴?；氯吉酸；綠源酸
    結(jié)構(gòu)分類
    初始來源
    運輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    溶解性數(shù)據(jù)
    細胞實驗： 

    DMSO 中的溶解度 : 100 mg/mL (282.24 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    H2O 中的溶解度 : ≥ 20 mg/mL (56.45 mM)

    * "≥" means soluble, but saturation unknown.

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 2.8224 mL 14.1119 mL 28.2239 mL
    5 mM 0.5645 mL 2.8224 mL 5.6448 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C儲存時，請在1年內(nèi)使用， -20°C儲存時，請在6個月內(nèi)使用。

    * 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實驗：

    請根據(jù)您的 實驗動物和給藥方式 選擇適當?shù)娜芙夥桨浮?

    以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
    ——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.06 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

      生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
    • 方案 二

      請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (7.06 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

      2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
    動物溶解方案計算器
    請輸入動物實驗的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實驗過程有損耗，建議您多配一只動物的量
    計算結(jié)果
    工作液所需濃度 : mg/mL
    該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
    您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
    純度 & 產(chǎn)品資料

    純度: 99.55%

    參考文獻

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C儲存時，請在1年內(nèi)使用， -20°C儲存時，請在6個月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.8224 mL 14.1119 mL 28.2239 mL 70.5597 mL
    5 mM 0.5645 mL 2.8224 mL 5.6448 mL 14.1119 mL
    10 mM 0.2822 mL 1.4112 mL 2.8224 mL 7.0560 mL
    15 mM 0.1882 mL 0.9408 mL 1.8816 mL 4.7040 mL
    20 mM 0.1411 mL 0.7056 mL 1.4112 mL 3.5280 mL
    25 mM 0.1129 mL 0.5645 mL 1.1290 mL 2.8224 mL
    30 mM 0.0941 mL 0.4704 mL 0.9408 mL 2.3520 mL
    40 mM 0.0706 mL 0.3528 mL 0.7056 mL 1.7640 mL
    50 mM 0.0564 mL 0.2822 mL 0.5645 mL 1.4112 mL
    DMSO 60 mM 0.0470 mL 0.2352 mL 0.4704 mL 1.1760 mL
    80 mM 0.0353 mL 0.1764 mL 0.3528 mL 0.8820 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7056 mL

    * 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    您最近查看的產(chǎn)品:

    Your information is safe with us. * Required Fields.

       產(chǎn)品名稱：

    		  

    * 需求量：

    * 客戶姓名：

    		 

    * Email：

    * 電話：

    		 

    * 公司或機構(gòu)名稱：

       留言給我們：

    Bulk Inquiry

    Inquiry Information

    產(chǎn)品名稱：
    Chlorogenic acid
    目錄號：
    HY-N0055
    需求量：