Honokiol (Synonyms: 和厚樸酚; NSC 293100)

目錄號(hào): HY-N0003 純度: 99.85%: FAQs
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摩爾計(jì)算器

Honokiol是一種具有生物活性的雙酚類植物化學(xué)物質(zhì)，靶向多種信號(hào)分子，具有有效的抗氧化，抗炎，抗血管生成和抗癌活性。它抑制 Akt 的活化。Honokiol 能透過血腦屏障。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Honokiol Chemical Structure

CAS No. : 35354-74-6

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規(guī)格	價(jià)格	是否有貨
10 mM * 1 mL in DMSO	￥500	In-stock
5 mg	￥281	In-stock
10 mg	￥450	In-stock
50 mg	￥550	In-stock
100 mg	￥770	In-stock
200 mg	￥990	In-stock
500 mg		詢價(jià)
1 g		詢價(jià)

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Customer Review

Other Forms of Honokiol:

Honokiol (Standard) 詢價(jià)

MCE 顧客使用本產(chǎn)品發(fā)表的 45 篇科研文獻(xiàn)

•J Adv Res. 2024 May 12:S2090-1232(24)00173-5. [Abstract]
•Cell Death Dis. 2023 Mar 1;14(3):174. [Abstract]
•Int J Biol Macromol. 2020 Mar 15;147:79-88. [Abstract]
•Cell Death Discov. 2024 Apr 8;10(1):167. [Abstract]
•J Transl Med. 2023 Jul 22;21(1):494. [Abstract]
•Cell Biosci. 2023 Mar 16;13(1):57. [Abstract]

•Chin Med J. 2023 Feb 21. [Abstract]
•Free Radic Biol Med. 2022 Dec 31;S0891-5849(22)01135-2. [Abstract]
•Mucosal Immunol. 2021 Oct 22. [Abstract]
•Phytomedicine. 8 September 2021, 153740.
•Aging Cell. 2021 Jan 15;e13306. [Abstract]
•Biomed Pharmacother. 2019 Jun 5;117:109058. [Abstract]
•Int J Mol Sci. 2024 Feb 18, 25(4), 2408.
•Neurosci Bull. 2023 Jun 9. [Abstract]
•Inflamm Bowel Dis. 2023 Jun 19;izad099. [Abstract]
•Aquaculture. 2023 Apr 8,739553.
•Pharmaceuticals. 2023, 16(1), 70.
•Fish Shellfish Immunol. 2022 Aug 31;S1050-4648(22)00535-6. [Abstract]
•Int Immunopharmacol. 2022 May 6;109:108819. [Abstract]
•Int Immunopharmacol. 2022 Feb 22;106:108600. [Abstract]
•Chem Biol Interact. 2021 Nov 6;109741. [Abstract]
•Food Chem Toxicol. 2021 Oct 5;112592. [Abstract]
•Food Funct. 6th July 2021.
•Eur J Pharmacol. 2021 Oct 5;908:174356. [Abstract]
•Mol Med. 2021 Apr 26;27(1):43. [Abstract]
•Neuropharmacology. 2021 Apr 29;108584. [Abstract]
•J Immunol. 2021 May 17;ji2001346. [Abstract]
•Inflammation. 2021 Oct;44(5):1782-1792. [Abstract]
•Int J Mol Med. 2020 Jan;45(1):186-194. [Abstract]
•Microbiol Spectr. 2024 Jun 25:e0074924. [Abstract]
•Am J Hypertens. 2024 Jul 18:hpae091. [Abstract]
•J Biol Chem. 2023 Dec 1:105526. [Abstract]
•Heliyon. 2023 Nov 28, e22939.
•Mol Biol Rep. 2023 Jun 20. [Abstract]
•Microbiol Spectr. 2023 May 22;e0327322. [Abstract]
•Exp Anim. 2023 Mar 2. [Abstract]
•Biochem Biophys Res Commun. 2022 Feb 17;600:109-116. [Abstract]
•Dig Dis Sci. 2022 Jan 7. [Abstract]
•Surg Oncol. 2020 Dec;35:191-199. [Abstract]
•PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681. [Abstract]
•AAPS PharmSciTech. 2018 Nov;19(8):3501-3511. [Abstract]
•J Obstet Gynaecol Res. 2024 Mar 13. [Abstract]
•bioRxiv. 2023 Jul 9.
•SSRN. 22 Apr 2022.
•Research Square Preprint. 2020 Oct.

: Honokiol purchased from MCE. Usage Cited in: Exp Anim. 2023 Mar 2. [Abstract]; IF staining assays demonstrates that Honokiol (5 mg/kg; i.p.; single) elevates the expression of SIRT3 in the lung tissues of APE (acute pulmonary embolism) rats.

: Honokiol purchased from MCE. Usage Cited in: Int J Biol Macromol. 2020 Mar 15;147:79-88. [Abstract]; Effect of GFP-A and Honokiol (activator of ERK1/2) (10 μmol/L) on the protein expression of NF-κB p65 in HT-29 cells. Cells were treated with 180 μg/mL GFP-A in the presence or absence of Honokiol for different durations of time. The expression of protein was analyzed by western blot. β-Actin was used as an equal loading control.

Honokiol 相關(guān)產(chǎn)品

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Akt Akt1 Akt2 Akt3

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ERK ERK1 ERK2 ERK5 ERK8

生物活性
實(shí)驗(yàn)參考方法
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier^[1]^[2]^[3]^[4].

IC₅₀ & Target^[4]

ERK1

ERK2

Autophagy

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A2780	IC₅₀	30.5 μM Compound: Honokiol	Antiproliferative activity against human A2780 cells after 24 hrs by MTT assay Antiproliferative activity against human A2780 cells after 24 hrs by MTT assay	[PMID: 31278004]
A2780	IC₅₀	30.5 μM Compound: 1	Antiproliferative activity against cisplatin-sensitive human A2780 cells by MTT assay Antiproliferative activity against cisplatin-sensitive human A2780 cells by MTT assay	[PMID: 19589678]
A2780	IC₅₀	31.58 μM Compound: HN; 2a	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
A2780	IC₅₀	41.2 μM Compound: 1	Antiproliferative activity against cisplatin-resistant human A2780 cells by MTT assay Antiproliferative activity against cisplatin-resistant human A2780 cells by MTT assay	[PMID: 19589678]
A549	IC₅₀	> 5 μg/mL Compound: 6	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 17918910]
A549	IC₅₀	12.51 μM Compound: Honokiol	Cytotoxicity against human A549 cells after 24 hrs by MTS assay Cytotoxicity against human A549 cells after 24 hrs by MTS assay	[PMID: 22533983]
A549	IC₅₀	29.7 μM Compound: Honokiol	Antiproliferative activity against human A549 cells by MTT assay Antiproliferative activity against human A549 cells by MTT assay	[PMID: 31278004]
A549	IC₅₀	34.1 μM Compound: Honokiol	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 31278004]
A549	IC₅₀	35 μM Compound: Honokiol	Antiproliferative activity against human A549 cells after 24 hrs by MTT assay Antiproliferative activity against human A549 cells after 24 hrs by MTT assay	[PMID: 21853991]
A549	IC₅₀	35 μM Compound: 1	Antiproliferative activity against human A549 cells by MTT assay Antiproliferative activity against human A549 cells by MTT assay	[PMID: 19589678]
A549	IC₅₀	35.31 μM Compound: 1; HK	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30006164]
A549	IC₅₀	35.41 μM Compound: Honokiol	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 31278004]
A549	IC₅₀	38.04 μM Compound: HN; 2a	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
A549	IC₅₀	7.75 μM Compound: Honokiol	Cytotoxicity against human A549 cells after 72 hrs by MTS assay Cytotoxicity against human A549 cells after 72 hrs by MTS assay	[PMID: 22533983]
BV-2	IC₅₀	17 μM Compound: 1	Anti-inflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay Anti-inflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay	[PMID: 30472026]
CHO	EC₅₀	> 10 μM Compound: 1	Agonist activity at recombinant human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 5 mins by cAMP-competition binding assay Agonist activity at recombinant human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 5 mins by cAMP-competition binding assay	[PMID: 24900561]
CNE2Z	IC₅₀	31.27 μM Compound: Honokiol	Antiproliferative activity against human CNE2Z cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human CNE2Z cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 31831382]
HCC827	IC₅₀	33.88 μM Compound: 1; HK	Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay	[PMID: 30006164]
HCT-116	IC₅₀	19.05 μM Compound: Honokiol	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 31278004]
HCT-116	IC₅₀	47.65 μM Compound: 35	Antitumor activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antitumor activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 36332549]
HEK293	ED₅₀	11.8 μM Compound: Honokiol	Agonist activity at human RXR-alpha expressed in HEK293 cells coexpressing with pCMX-beta-gal after 24 to 48 hrs by luciferase reporter gene assay Agonist activity at human RXR-alpha expressed in HEK293 cells coexpressing with pCMX-beta-gal after 24 to 48 hrs by luciferase reporter gene assay	[PMID: 24959987]
HEK293	EC₅₀	11.8 μM Compound: 1	Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay	[PMID: 20695472]
HEK293	IC₅₀	40 μM Compound: Ho	Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 2 days by MTT assay Cytotoxicity against HEK293 cells assessed as decrease in cell viability after 2 days by MTT assay	[PMID: 30733086]
HEK293	IC₅₀	9.3 μg/mL Compound: Honokiol	Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 27259399]
HeLa	IC₅₀	> 5 μg/mL Compound: 6	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 17918910]
HepG2	IC₅₀	16.5 μM Compound: Honokiol	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 21853991]
HepG2	IC₅₀	23.85 μM Compound: HN; 2a	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
HepG2	IC₅₀	32.9 μM Compound: Honokiol	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 31278004]
HepG2	IC₅₀	33.88 μM Compound: Honokiol	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 31278004]
HepG2	IC₅₀	34.3 μM Compound: Honokiol	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 31278004]
HT-29	IC₅₀	13.24 μM Compound: Honokiol	Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay	[PMID: 22533983]
HT-29	IC₅₀	23.05 μM Compound: Honokiol	Cytotoxicity against human HT-29 cells after 24 hrs by MTS assay Cytotoxicity against human HT-29 cells after 24 hrs by MTS assay	[PMID: 22533983]
HT-29	IC₅₀	25 μM Compound: Ho	Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 2 days by MTT assay Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 2 days by MTT assay	[PMID: 30733086]
HT-29	IC₅₀	31.58 μM Compound: HN; 2a	Antiproliferative activity against human HT29 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HT29 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
HT-29	IC₅₀	6.1 μg/mL Compound: Honokiol	Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 27259399]
Huh-7	IC₅₀	58.5 μM Compound: Honokiol	Cytotoxicity against human Huh7.5 cells after 72 hrs Cytotoxicity against human Huh7.5 cells after 72 hrs	[PMID: 24400834]
HUVEC	IC₅₀	52.6 μM Compound: Honokiol	Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay	[PMID: 21853991]
I10	IC₅₀	31.11 μM Compound: Honokiol	Antiproliferative activity against mouse I10 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against mouse I10 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 31831382]
K562	IC₅₀	> 5 μg/mL Compound: 6	Cytotoxicity against human K562 cells by MTT assay Cytotoxicity against human K562 cells by MTT assay	[PMID: 17918910]
K562	IC₅₀	21.1 μM Compound: 1	Antiproliferative activity against human K562 cells by MTT assay Antiproliferative activity against human K562 cells by MTT assay	[PMID: 19589678]
K562	IC₅₀	22.1 μM Compound: Honokiol	Antiproliferative activity against human K562 cells after 24 hrs by MTT assay Antiproliferative activity against human K562 cells after 24 hrs by MTT assay	[PMID: 31278004]
K562	IC₅₀	23.91 μM Compound: Honokiol	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 31278004]
K562	IC₅₀	28.4 μM Compound: Honokiol	Antiproliferative activity against human K562 cells by MTT assay Antiproliferative activity against human K562 cells by MTT assay	[PMID: 31278004]
L02	IC₅₀	25.49 μM Compound: HN; 2a	Antiproliferative activity against human L02 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human L02 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
Lewis lung carcinoma cell line	IC₅₀	65.4 μM Compound: Honokiol	Antiproliferative activity against mouse LL/2 cells after 24 hrs by MTT assay Antiproliferative activity against mouse LL/2 cells after 24 hrs by MTT assay	[PMID: 21853991]
MCF7	IC₅₀	35 μM Compound: Ho	Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 2 days by MTT assay Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 2 days by MTT assay	[PMID: 30733086]
MCF7	IC₅₀	41.8 μM Compound: Honokiol	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 31831382]
MCF7	IC₅₀	5 μg/mL Compound: Honokiol	Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 27259399]
MDA-MB-231	IC₅₀	44.89 μM Compound: Honokiol	Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay	[PMID: 34605238]
NCI-H1650	IC₅₀	37.35 μM Compound: 1; HK	Antiproliferative activity against human NCI-H1650 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1650 cells after 72 hrs by MTT assay	[PMID: 30006164]
NCI-H1975	IC₅₀	30.2 μM Compound: Honokiol	Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay	[PMID: 31278004]
NCI-H1975	IC₅₀	30.2 μM Compound: 1; HK	Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay	[PMID: 30006164]
NCI-H358	IC₅₀	31.57 μM Compound: 1; HK	Antiproliferative activity against human NCI-H358 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H358 cells after 72 hrs by MTT assay	[PMID: 30006164]
NCI-H441	IC₅₀	33.32 μM Compound: 1; HK	Antiproliferative activity against human H441 cells after 72 hrs by MTT assay Antiproliferative activity against human H441 cells after 72 hrs by MTT assay	[PMID: 30006164]
NCI-H460	IC₅₀	38.46 μM Compound: 1; HK	Antiproliferative activity against human H460 cells after 72 hrs by MTT assay Antiproliferative activity against human H460 cells after 72 hrs by MTT assay	[PMID: 30006164]
Oocyte	EC₅₀	23.4 μM Compound: Hon, HK	Modulation of GABA Aalpha5beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha5beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	36.2 μM Compound: Hon, HK	Modulation of GABA alpha1beta2gamma2s receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA alpha1beta2gamma2s receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	39.3 μM Compound: Hon, HK	Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	46.4 μM Compound: Hon, HK	Modulation of GABA Aalpha2beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha2beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	52.4 μM Compound: Hon, HK	Modulation of GABA Aalpha3beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha3beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	57 μM Compound: Hon, HK	Modulation of GABA Aalpha1beta1 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha1beta1 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
Oocyte	EC₅₀	59.6 μM Compound: Hon, HK	Modulation of GABA Aalpha1beta3 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique Modulation of GABA Aalpha1beta3 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique	[PMID: 21699169]
PANC-1	IC₅₀	31.24 μM Compound: HN; 2a	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
PC-3	IC₅₀	29.03 μM Compound: HN; 2a	Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 32996316]
PC-9	IC₅₀	36.72 μM Compound: 1; HK	Antiproliferative activity against human PC9 cells after 72 hrs by MTT assay Antiproliferative activity against human PC9 cells after 72 hrs by MTT assay	[PMID: 30006164]
Platelet	IC₅₀	0.6 μM Compound: 2	Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry	[PMID: 32463237]
RKO	IC₅₀	11.42 μM Compound: 35	Antitumor activity against human RKO cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antitumor activity against human RKO cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 36332549]
SW480	IC₅₀	15.14 μM Compound: 35	Antitumor activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antitumor activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 36332549]
UACC-903	IC₅₀	5.1 μM Compound: Honokiol	Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay	[PMID: 22533983]
UACC-903	IC₅₀	7.45 μM Compound: Honokiol	Cytotoxicity against human UACC-903 cells after 24 hrs by MTS assay Cytotoxicity against human UACC-903 cells after 24 hrs by MTS assay	[PMID: 22533983]
Vero	EC₅₀	6.5 μM Compound: 18	Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA	[PMID: 17663539]
Vero	CC₅₀	88.9 μM Compound: 18	Cytotoxicity against Vero E6 cells by MTT assay Cytotoxicity against Vero E6 cells by MTT assay	[PMID: 17663539]

體外研究
(In Vitro)

Honokiol (0、12.5、25 和 50 μM) 抑制 GBM 細(xì)胞的生長(zhǎng)并誘導(dǎo)細(xì)胞凋亡，對(duì) 30 μM DBTRG-05MG 細(xì)胞的 IC₅₀ 約為。Honokiol 誘導(dǎo)的 GBM 細(xì)胞凋亡與 Rb 蛋白的下調(diào)和 PARP 和 Bcl-x (S/L) 的裂解有關(guān)。Honokiol (50 μM) 增加 GBM 細(xì)胞中自噬標(biāo)記物的水平^[1]。
Honokiol 具有抗癌作用，對(duì)MDA-MB-231、MDA-MB-468、MDA-MB-453細(xì)胞系的IC₅₀值為16.99 ± 1.28 μM，15.94 ±分別為 2.35 μM 和 20.11 ±3.13 μM。Honokiol (3，10 μM) 在克隆形成試驗(yàn)中對(duì)球體數(shù)量和球體大小產(chǎn)生顯著抑制作用^[2]。
Honokiol (0.1-1.0 μM) 特異性抑制由膠原蛋白刺激的洗滌過的人血小板聚集，但不抑制其他激動(dòng)劑刺激的血小板聚集。honokiol (0.6 和 1.0 μM) 可以濃度依賴性地抑制洗滌過的人血小板中膠原誘導(dǎo)的 ATP 釋放反應(yīng)。Honokiol 可特異性抑制驚厥素刺激的血小板聚集和 Lyn、PLCγ2 和 PKC 的磷酸化。Honokiol (5，10 μM) 顯著抑制驚厥素刺激的 MAPK 和 Akt 激活^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)研究
(In Vivo)

Honokiol-NM (40 mg/kg，po) 產(chǎn)生優(yōu)異的抗癌作用，PCNA、Cyclin D1 和 cleaved caspase 3 表達(dá)在該處理組中顯著改變 2.12、1.92 和 1.68 倍^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

266.33

Formula

C₁₈H₁₈O₂

CAS 號(hào)

35354-74-6

性狀

固體

顏色

White to off-white

中文名稱

和厚樸酚

結(jié)構(gòu)分類

初始來源

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

溶解性數(shù)據(jù)

細(xì)胞實(shí)驗(yàn)：

DMSO 中的溶解度 : ≥ 50 mg/mL (187.74 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	3.7547 mL	18.7737 mL	37.5474 mL
5 mM	0.7509 mL	3.7547 mL	7.5095 mL
10 mM	0.3755 mL	1.8774 mL	3.7547 mL

查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

摩爾計(jì)算器
稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動(dòng)物實(shí)驗(yàn)：

請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

方案一

請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.39 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水定容至 1 mL。
生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
方案二

請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.39 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液中，混合均勻。
2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
方案三

請(qǐng)依序添加每種溶劑： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.39 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液，此方案實(shí)驗(yàn)周期在半個(gè)月以上的動(dòng)物實(shí)驗(yàn)酌情使用。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL玉米油中，混合均勻。

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

方案一

請(qǐng)依序添加每種溶劑： Corn Oil
Solubility: 16.67 mg/mL (62.59 mM); 澄清溶液; 超聲助溶

動(dòng)物溶解方案計(jì)算器

請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只

由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量

請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：

DMSO +

Tween-80 +

Saline

如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。

方案所需 助溶劑 包括：DMSO，，均可在 MCE 網(wǎng)站選購(gòu)。，Tween 80，均可在 MCE 網(wǎng)站選購(gòu)。

計(jì)算結(jié)果

工作液所需濃度 : mg/mL

儲(chǔ)備液配制方法 : mg 藥物溶于 μL DMSO（母液濃度為 mg/mL）。

您所需的儲(chǔ)備液濃度超過該產(chǎn)品的實(shí)測(cè)溶解度，以下方案僅供參考，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。

動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。

連續(xù)給藥周期超過半月以上，請(qǐng)謹(jǐn)慎選擇該方案。

請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱（超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。

純度 & 產(chǎn)品資料

純度: 99.90%

選擇批次：

Data Sheet (654 KB) SDS (620 KB)

COA (288 KB) HNMR (197 KB) LCMS (482 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Chang KH, et al. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett. 2013 Nov;6(5):1435-1438. [Content Brief]

[2]. Godugu C, et al. Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC). Colloids Surf B Biointerfaces. 2017 Jan 23;153:208-219 [Content Brief]

[3]. Lee TY, et al. Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Sci Rep. 2017 Jan 5;7:40002 [Content Brief]

[4]. Zhai H, et al. Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2). Eur J Pharmacol. 2005 Jun 1;516(2):112-7. [Content Brief]

Cell Assay ^[2]	In cytotoxicity assays, 10,000 cells/well are added to 96 wells plates and incubated overnight, thereafter cells are treated with different concentrations of Honokiol dissolved in dimethylsulphoxide (DMSO). Since Honokiol is not soluble in aqueous solvents, for in vitro studies Honokiol is dissolved in DMSO. To study the possible effect of DMSO on cells, solvent (DMSO) control is used at highest concentration of <0.1%. After 72 h treatment, cells are fixed and cell viability is measured by crystal violet staining (0.05%). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[2]	For anticancer in vivo studies, the MDA-MB-231 cells (2 million) are injected into mammary fat tissue. Two weeks after the tumor cell injections, palpable tumors are observed in mammary tissues, which is an indication of tumor formation. Then drug treatment either in free form or in nanomicellar forms is given orally at the dose of 40 and 80 mg/kg daily. The drug treatment is continued for 4 weeks, and the tumor volumes and body weights are recorded weekly. After 4 weeks of treatment, animals are sacrificed; final tumor volumes and weights are measured. These tumors are used for western blot and immunohistochemical analysis. For western blot experiments, tumor tissues are stored at ?80°C till the analysis is done. For IHC, tumors are fixed in formal saline. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)	[1]. Chang KH, et al. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett. 2013 Nov;6(5):1435-1438. [Content Brief] [2]. Godugu C, et al. Honokiol nanomicellar formulation produced increased oral bioavailability and anticancer effects in triple negative breast cancer (TNBC). Colloids Surf B Biointerfaces. 2017 Jan 23;153:208-219 [Content Brief] [3]. Lee TY, et al. Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies. Sci Rep. 2017 Jan 5;7:40002 [Content Brief] [4]. Zhai H, et al. Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2). Eur J Pharmacol. 2005 Jun 1;516(2):112-7. [Content Brief]

Honokiol 相關(guān)分類

完整儲(chǔ)備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7547 mL	18.7737 mL	37.5474 mL	93.8685 mL
	5 mM	0.7509 mL	3.7547 mL	7.5095 mL	18.7737 mL
	10 mM	0.3755 mL	1.8774 mL	3.7547 mL	9.3869 mL
	15 mM	0.2503 mL	1.2516 mL	2.5032 mL	6.2579 mL
	20 mM	0.1877 mL	0.9387 mL	1.8774 mL	4.6934 mL
	25 mM	0.1502 mL	0.7509 mL	1.5019 mL	3.7547 mL
	30 mM	0.1252 mL	0.6258 mL	1.2516 mL	3.1290 mL
	40 mM	0.0939 mL	0.4693 mL	0.9387 mL	2.3467 mL
	50 mM	0.0751 mL	0.3755 mL	0.7509 mL	1.8774 mL
	60 mM	0.0626 mL	0.3129 mL	0.6258 mL	1.5645 mL
	80 mM	0.0469 mL	0.2347 mL	0.4693 mL	1.1734 mL
	100 mM	0.0375 mL	0.1877 mL	0.3755 mL	0.9387 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Honokiol35354-74-6NSC 293100和厚樸酚NSC293100NSC-293100AktAutophagyHCVERKPKBProtein kinase BHepatitis C virusExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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Honokiol (Synonyms: 和厚樸酚; NSC 293100)

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MCE 顧客使用本產(chǎn)品發(fā)表的 45 篇科研文獻(xiàn)

Honokiol 相關(guān)產(chǎn)品

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生物活性

實(shí)驗(yàn)參考方法

純度 & 產(chǎn)品資料

參考文獻(xiàn)

摩爾計(jì)算器

稀釋計(jì)算器

Honokiol 相關(guān)分類

完整儲(chǔ)備液配制表

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Honokiol (Synonyms: 和厚樸酚; NSC 293100)

Customer Review

Other Forms of Honokiol:

Honokiol 相關(guān)抗體

MCE 顧客使用本產(chǎn)品發(fā)表的 45 篇科研文獻(xiàn)

Honokiol 相關(guān)產(chǎn)品

•相關(guān)化合物庫(kù):

•同靶點(diǎn)產(chǎn)品:

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Honokiol 相關(guān)抗體:

摩爾計(jì)算器

稀釋計(jì)算器

Honokiol 相關(guān)分類

完整儲(chǔ)備液配制表

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