Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities^[1][2].

Chitosan (2 mg/mL；48 小時；SKMEL28 和 RPMI7951 細胞) 處理顯示生長潛能降低^[1]。
Chitosan (2 mg/mL；48 小時；RPMI7951 細胞) 處理通過線粒體途徑顯示出對 RPMI7951 的強促凋亡作用^[1]。
Chitosan (2 mg/mL；48 小時；RPMI7951 細胞) 處理誘導(dǎo)促凋亡分子的上調(diào)例如 Bax 和 Bcl-2 和 Bcl-XL 等抗凋亡蛋白的下調(diào)^[1]。
低分子量殼聚糖可以穿透細菌細胞壁，與 DNA 結(jié)合并抑制DNA轉(zhuǎn)錄和mRNA合成，而高分子量的殼聚糖可以與細菌細胞壁上的負電荷成分結(jié)合。它在細胞周圍形成一個不透水層，改變細胞通透性并阻斷向細胞內(nèi)的運輸。Chitosan還可用于水處理、傷口愈合材料、藥物賦形劑或藥物載體、肥胖癥研究以及作為組織工程支架^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

在 ICR 小鼠的化學(xué)誘導(dǎo)的結(jié)腸癌前病變中，在為期 2 周的預(yù)防性實驗中，喂食含有高分子量殼聚糖 (HMWC) 的飲食的小鼠與喂食對照飲食的小鼠相比，異常隱窩病灶形成明顯減少。隨著處理延長至 6 周，與對照組相比，低分子量殼聚糖 (LMWC) 和 HMWC 喂養(yǎng)的小鼠都含有較少的異常隱窩病灶^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

150000.00(Average)

(C₆H₁₃NO₅)n

9012-76-4

固體

White to light yellow

殼聚糖 (MW 150000)； 脫乙酰殼多糖 (MW 150000)； 甲殼素 (MW 150000)

Room temperature in continental US; may vary elsewhere.

• [1]. Laure Gibot, et al. Anticancer properties of chitosan on human melanoma are cell line dependent. Int J Biol Macromol. 2015 Jan;72:370-9.  [Content Brief]

  [2]. Randy Chi Fai Cheung, et al. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications. Mar Drugs. 2015 Aug 14;13(8):5156-86.  [Content Brief]

  [3]. Shyr-Yi Lin, et al. Chitosan prevents the development of AOM-induced aberrant crypt foci in mice and suppressed the proliferation of AGS cells by inhibiting DNA synthesis. J Cell Biochem. 2007 Apr 15;100(6):1573-80.  [Content Brief]