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  2. 誘導(dǎo)疾病模型產(chǎn)品 NF-κB Immunology/Inflammation Metabolic Enzyme/Protease
  3. 心血管系統(tǒng)疾病模型 Reactive Oxygen Species Endogenous Metabolite
  4. 高血壓模型
  5. Uric acid

Uric acid  (Synonyms: 尿酸)

目錄號: HY-B2130 純度: 99.96%
COA 產(chǎn)品使用指南

Uric acid 是氧自由基 (oxygen radical) 的清除劑，是一種非常重要的抗氧化劑，有助于維持血壓的穩(wěn)定和抗氧化應(yīng)激。Uric acid 能清除活性氧 (ROS)，如單線態(tài)氧和過氧亞硝酸鹽，抑制脂質(zhì)過氧化。

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Uric acid Chemical Structure

Uric acid Chemical Structure

CAS No. : 69-93-2

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規(guī)格 價格 是否有貨 數(shù)量
500 mg ￥400
In-stock
1 g ￥500
In-stock
5 g   詢價  
10 g   詢價  

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Customer Review

Other Forms of Uric acid:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].

IC50 & Target

Human Endogenous Metabolite

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
0.3 mM
Compound: 1175
Substrate uptake by the Glucose Transporter Type 9 (GLUT9, SLC2A9) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC2A9 isoform 1
Substrate uptake by the Glucose Transporter Type 9 (GLUT9, SLC2A9) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC2A9 isoform 1
10.5281/zenodo.7360607
體外研究
(In Vitro)

Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation[2].
Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Uric acid (250 mg/kg; p.o.) ameliorates indomethacin-induced enteropathy[2].
Oral administration of uric acid decreased ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male C57BL/6J mice[2]
Dosage: 250 mg/kg body weight
Administration: P.o.
Result: When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.
Clinical Trial
分子量

168.11

Formula

C5H4N4O3
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

尿酸
結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

1M NaOH 中的溶解度 : 8.33 mg/mL (49.55 mM; ultrasonic and warming and adjust pH to 12 with 1M NaOH and heat to 60°C)

H2O 中的溶解度 : 6.25 mg/mL (37.18 mM; ultrasonic and adjust pH to 10 with 1M NaOH)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 5.9485 mL 29.7424 mL 59.4849 mL
5 mM 1.1897 mL 5.9485 mL 11.8970 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實(shí)驗(yàn)：

以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑： 0.5% CMC-Na/saline water

    Solubility: 10 mg/mL (59.48 mM); 懸濁液; 超聲助溶

動物溶解方案計算器
請輸入動物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
您所需的儲備液濃度超過該產(chǎn)品的實(shí)測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.96%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O / 1M NaOH 1 mM 5.9485 mL 29.7424 mL 59.4849 mL 148.7122 mL
5 mM 1.1897 mL 5.9485 mL 11.8970 mL 29.7424 mL
10 mM 0.5948 mL 2.9742 mL 5.9485 mL 14.8712 mL
15 mM 0.3966 mL 1.9828 mL 3.9657 mL 9.9141 mL
20 mM 0.2974 mL 1.4871 mL 2.9742 mL 7.4356 mL
25 mM 0.2379 mL 1.1897 mL 2.3794 mL 5.9485 mL
30 mM 0.1983 mL 0.9914 mL 1.9828 mL 4.9571 mL
1M NaOH 40 mM 0.1487 mL 0.7436 mL 1.4871 mL 3.7178 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Uric acid
目錄號：
HY-B2130
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