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  2. Anti-infection
  3. Bacterial Antibiotic
  4. Spectinomycin dihydrochloride pentahydrate

Spectinomycin dihydrochloride pentahydrate  (Synonyms: 鹽酸大觀霉素五水合物; Spectinomycin hydrochloride hydrate)

目錄號: HY-B1828A 純度: ≥98.0%
COA 產品使用指南

Spectinomycin dihydrochloride pentahydrate 是一種廣譜抗生素，可以抑制多種革蘭氏陽性和革蘭氏陰性細菌的生長。Spectinomycin dihydrochloride pentahydrate 通過特異靶向細菌核糖體，干擾蛋白質合成。Spectinomycin dihydrochloride pentahydrate 也是 td 內含子 RNA 的非競爭性抑制劑，Ki 為 7.2 mM。

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Spectinomycin dihydrochloride pentahydrate Chemical Structure

Spectinomycin dihydrochloride pentahydrate Chemical Structure

CAS No. : 22189-32-8

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規(guī)格 價格 是否有貨 數量
10 mM * 1 mL in Water ￥550
In-stock
500 mg ￥500
In-stock
1 g   詢價  
5 g   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Spectinomycin dihydrochloride pentahydrate:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Spectinomycin dihydrochloride pentahydrate is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin dihydrochloride pentahydrate acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin dihydrochloride pentahydrate is also a noncompetitive inhibitor of td intron RNA with an Ki value of 7.2 mM[1]-[5].

IC50 & Target

bacterial ribosomal subunit[5]
體外研究
(In Vitro)

Spectinomycin dihydrochloride pentahydrate selectively inhibits protein synthesis in cells and in extracts of Escherichia coli:
Spectinomycin dihydrochloride pentahydrate (50 μg/mL) inhibits Escherichia coli growth rapidly and reversibly, and suppresses amino acid incorporation immediately[1].
Spectinomycin dihydrochloride pentahydrate (1 μg/mL or 3 μM) inhibits polypeptide synthesis directed either by endogenous messenger RNA or by MS-2 bacteriophage RNA, with maximum inhibition of 70-80% in extracts of Escherichia coli[1].
Spectinomycin dihydrochloride pentahydrate blocks the translocation of peptidyl-tRNAs from A-site to P-site by inhibiting the binding of elongation factor G to the ribosome[2].
Spectinomycin dihydrochloride pentahydrate interacts specifically with the residues G1064 and 01192 in 16S rRNA and potentially makes it inactive[2].
Spectinomycin dihydrochloride pentahydrate exhibits splicing inhibition and dependent on pH changes and Mg2+ concentration, indicating electrostatic interactions with the intron RNA[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內研究
(In Vivo)

Spectinomycin dihydrochloride pentahydrate (20 mg/kg; i.m.; 20-100 mg/kg; 9 d) shows the safety in healthy chicks[4].
Spectinomycin dihydrochloride pentahydrate (10 mg/kg; i.v.; single dose) has the major elimination pathway by renal excretion, approximately 55% is excreted into the urine in unchanged form[5].
Pharmacokinetics of Spectinomycin dihydrochloride pentahydrate in Rat[5]

Parameter C0 (μg/mL) AUC0-∞ (μg?h/mL) Vd (L/kg) CL (L/h/kg) MRT (h) T1/2α (h) T1/2β (h) T1/2γ (h) fe CLrenal (L/h/kg) Eratio
Non atrioventricular analysis 44.3 16.8 0.756 0.602 0.757 / / / 0.553 0.359 1.00
Three-compartment model 37.8 15.7 0.747 0.649 1.11 / 0.237 0.754 19.5 / /

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Arbor Acres plus broiler chicks (15-day-old)[4]
Dosage: 20 mg/kg, 60 mg/kg, 100 mg/kg
Administration: Intramuscular injection (chest muscles); 9 days
Result: Showed biosecurity of 20 mg/kg by complete blood count, biochemical parameters, histopathological, clinical signs, body weight gain, and feed conversion ratio (FCR).
Resulted minor toxicity of 60 mg/kg.
分子量

495.35

Formula

C14H36Cl2N2O12
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

鹽酸大觀霉素五水合物
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數據
細胞實驗： 

H2O 中的溶解度 : 62.5 mg/mL (126.17 mM; 超聲助溶)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 2.0188 mL 10.0939 mL 20.1877 mL
5 mM 0.4038 mL 2.0188 mL 4.0375 mL
查看完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

以下溶解方案，請直接配制工作液。建議現用現配，在短期內盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現沉淀、析出現象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑： PBS

    Solubility: 50 mg/mL (100.94 mM); 澄清溶液; 超聲助溶

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
該產品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數據。
您所需的儲備液濃度超過該產品的實測溶解度，如有需要，請與 MCE 中國技術支持聯系。
純度 & 產品資料

純度: ≥98.0%

參考文獻

Spectinomycin dihydrochloride pentahydrate 相關分類

完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0188 mL 10.0939 mL 20.1877 mL 50.4694 mL
5 mM 0.4038 mL 2.0188 mL 4.0375 mL 10.0939 mL
10 mM 0.2019 mL 1.0094 mL 2.0188 mL 5.0469 mL
15 mM 0.1346 mL 0.6729 mL 1.3458 mL 3.3646 mL
20 mM 0.1009 mL 0.5047 mL 1.0094 mL 2.5235 mL
25 mM 0.0808 mL 0.4038 mL 0.8075 mL 2.0188 mL
30 mM 0.0673 mL 0.3365 mL 0.6729 mL 1.6823 mL
40 mM 0.0505 mL 0.2523 mL 0.5047 mL 1.2617 mL
50 mM 0.0404 mL 0.2019 mL 0.4038 mL 1.0094 mL
60 mM 0.0336 mL 0.1682 mL 0.3365 mL 0.8412 mL
80 mM 0.0252 mL 0.1262 mL 0.2523 mL 0.6309 mL
100 mM 0.0202 mL 0.1009 mL 0.2019 mL 0.5047 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Spectinomycin dihydrochloride pentahydrate
目錄號：
HY-B1828A
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