Digitoxin (Synonyms: 洋地黃毒苷)

目錄號(hào): HY-B1357 純度: 99.36%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南技術(shù)支持

Digitoxin 是一種抗癌劑。Digitoxin 可誘導(dǎo)細(xì)胞凋亡 (apoptosis)、抑制流感細(xì)胞因子風(fēng)暴、引起 DNA 雙鏈斷裂(DSBs)、將細(xì)胞周期阻滯在 G2/M 期。Digitoxin 通過形成跨膜鈣通道誘導(dǎo)細(xì)胞內(nèi)鈣攝取，可用于心力衰竭的研究。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Digitoxin Chemical Structure

CAS No. : 71-63-6

1. 客戶無需承擔(dān)相應(yīng)的運(yùn)輸費(fèi)用。

2. 同一機(jī)構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機(jī)構(gòu)（單位）一年內(nèi)

可免費(fèi)申領(lǐng)三個(gè)不同產(chǎn)品的試用裝。

3. 試用裝只面向終端客戶。

規(guī)格	價(jià)格	是否有貨
10 mM * 1 mL in DMSO	￥673	In-stock
5 mg	￥500	In-stock
10 mg	￥800	In-stock
25 mg	￥1600	In-stock
50 mg	￥2400	In-stock
100 mg	￥3600	In-stock
200 mg		詢價(jià)
500 mg		詢價(jià)

or 大包裝詢價(jià)

* Please select Quantity before adding items.

Customer Review

Other Forms of Digitoxin:

Gitoxin In-stock
Digitoxin-d₃ 詢價(jià)
Digitoxin (Standard) 詢價(jià)

MCE 顧客使用本產(chǎn)品發(fā)表的 6 篇科研文獻(xiàn)

•Front Pharmacol. 2024 Sep 4:15:1433137. [Abstract]
•Gynecol Oncol. 2024 Jul 5:188:162-168. [Abstract]
•Oncol Rep. 2024 Aug;52(2):103. [Abstract]
•Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. [Abstract]
•University of Saskatchewan. 2020 Jun 22.
•Nat Metab. 2019 Nov;1(11):1074-1088. [Abstract]

Digitoxin 相關(guān)產(chǎn)品

•相關(guān)化合物庫(kù):

•同靶點(diǎn)產(chǎn)品:

•同靶點(diǎn)蛋白產(chǎn)品:

查看 Bcl-2 Family 亞型特異性產(chǎn)品:

查看所有亞型

Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

查看 Caspase 亞型特異性產(chǎn)品:

查看所有亞型

Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 HSV 亞型特異性產(chǎn)品:

查看所有亞型

HSV-1 HSV-2 HSV

查看 Calcium Channel 亞型特異性產(chǎn)品:

查看所有亞型

N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

生物活性
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure ^[1]^[2]^[3]^[4]^[5].

IC₅₀ & Target

Bcl-2

Caspase-9

Caspase 3

Bax

HSV-1

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human A549 cells after 72 hrs by calcein AM assay Cytotoxicity against human A549 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
Cancer cell lines	IC₅₀	0.1 μM Compound: 2	Cytotoxicity against human colon cancer cells after 72 hrs by FMCA method Cytotoxicity against human colon cancer cells after 72 hrs by FMCA method	[PMID: 19894733]
DU-145	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human DU145 cells after 72 hrs by calcein AM assay Cytotoxicity against human DU145 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
HCT-116	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human HCT116 cells after 72 hrs by calcein AM assay Cytotoxicity against human HCT116 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
HCT-116	IC₅₀	0.74 μM Compound: 2	Cytotoxicity against human HCT116 cells after 72 hrs by FMCA method Cytotoxicity against human HCT116 cells after 72 hrs by FMCA method	[PMID: 19894733]
Hep 3B2	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human Hep3B cells after 72 hrs by calcein AM assay Cytotoxicity against human Hep3B cells after 72 hrs by calcein AM assay	[PMID: 16309329]
HFF	CC₅₀	2.8 μM Compound: 1	Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay	[PMID: 24900847]
HFF	CC₅₀	6 μM Compound: 1	Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay	[PMID: 24900847]
HT-29	IC₅₀	0.068 μM Compound: (+)-Digitoxin	Cytotoxicity against human HT-29 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay Cytotoxicity against human HT-29 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay	[PMID: 32096998]
HT-29	IC₅₀	4.07 μM Compound: 2	Cytotoxicity against human HT-29 cells after 72 hrs by FMCA method Cytotoxicity against human HT-29 cells after 72 hrs by FMCA method	[PMID: 19894733]
HT-29	IC₅₀	67.6 nM Compound: Digitoxin	Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
K562	IC₅₀	6.4 nM Compound: 1	Cytotoxicity against human K562 cells by XTT assay Cytotoxicity against human K562 cells by XTT assay	[PMID: 16309315]
KURAMOCHI	IC₅₀	5911 nM Compound: Digitoxin	Antiproliferative activity against human Kuramochi cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human Kuramochi cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
MCF7	IC₅₀	0.02 μM Compound: 1, DT	Antiproliferative activity against human MCF7 cells assessed as cell viability treated for 48 hrs followed by compound washout measured after 72 hrs by fluorometric CellTiter-Blue reagent assay Antiproliferative activity against human MCF7 cells assessed as cell viability treated for 48 hrs followed by compound washout measured after 72 hrs by fluorometric CellTiter-Blue reagent assay	[PMID: 21421322]
MCF7	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human MCF7 cells after 72 hrs by calcein AM assay Cytotoxicity against human MCF7 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
MCF7	IC₅₀	10.2 nM Compound: 1	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 16309315]
MDA-MB-231	IC₅₀	0.48 μM Compound: (+)-Digitoxin	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay	[PMID: 32096998]
MDA-MB-231	IC₅₀	482 nM Compound: Digitoxin	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
MDA-MB-435	IC₅₀	0.043 μM Compound: (+)-Digitoxin	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay	[PMID: 32096998]
MDA-MB-435	IC₅₀	43.3 nM Compound: Digitoxin	Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
NCI/ADR-RES	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human NCI/ADR-RES cells after 72 hrs by calcein AM assay Cytotoxicity against human NCI/ADR-RES cells after 72 hrs by calcein AM assay	[PMID: 16309329]
NCI-H460	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human NCI-H460 cells after 72 hrs by calcein AM assay Cytotoxicity against human NCI-H460 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
NCI-H460	GI₅₀	10.7 nM Compound: 1	Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 21643465]
NCI-H460	IC₅₀	357 nM Compound: 1	Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining	[PMID: 21643465]
OVCAR-3	IC₅₀	0.12 μM Compound: (+)-Digitoxin	Cytotoxicity against human OVCAR3 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay Cytotoxicity against human OVCAR3 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay	[PMID: 32096998]
OVCAR-3	IC₅₀	117.1 nM Compound: Digitoxin	Antiproliferative activity against human OVCAR3 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human OVCAR3 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
OVCAR-4	IC₅₀	425.6 nM Compound: Digitoxin	Antiproliferative activity against human OVCAR4 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human OVCAR4 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
OVCAR-5	IC₅₀	321 nM Compound: Digitoxin	Antiproliferative activity against human OVCAR5 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human OVCAR5 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
OVCAR-8	IC₅₀	71.5 nM Compound: Digitoxin	Antiproliferative activity against human OVCAR8 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human OVCAR8 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
SF-268	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human SF268 cells after 72 hrs by calcein AM assay Cytotoxicity against human SF268 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
SK-OV-3	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human SKOV3 cells after 72 hrs by calcein AM assay Cytotoxicity against human SKOV3 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
TK-10	IC₅₀	3.2 nM Compound: 1	Cytotoxicity against human TK10 cells after 48 hrs by SRB assay Cytotoxicity against human TK10 cells after 48 hrs by SRB assay	[PMID: 16309315]
UACC-62	IC₅₀	33.5 nM Compound: 1	Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay	[PMID: 16309315]
Vero	IC₅₀	< 0.23 μM Compound: Digitoxin	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	10.1101/2020.03.20.999730
Vero	CC₅₀	> 50 μM Compound: Digitoxin	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	10.1101/2020.03.20.999730

體外研究
(In Vitro)

Digitoxin (0-80 nM, 72 h) 降低 PC12 細(xì)胞的存活率^[1]。
Digitoxin (4-1000 nM, 24-48 h) 在 MHCC97H, A549, HCT116 和 HeLa 細(xì)胞中具有抗腫瘤作用^[3]。
Digitoxin (4-100 nM, 24-48 h) 干擾 HeLa 細(xì)胞的細(xì)胞周期^[3]。
Digitoxin (20-500 nM, 48 h) 激活 HeLa 細(xì)胞線粒體凋亡^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:	MHCC97H, A549, HCT116 and HeLa cells
Concentration:	4-1000 nM
Incubation Time:	24 h, 48 h
Result:	Dcreased the viability of these cancer cells in a dose- and time-dependent manner, with the IC₅₀ values ranging from 0.075 to 0.395 μM following digitoxin treatment for 24 h and from 0.028 to 0.077 μM following digitoxin treatment for 48 h.

Cell Cycle Analysis^[3]

Cell Line:	HeLa cells
Concentration:	4 nM, 20 nM, 100 nM
Incubation Time:	24 h, 36 h, 48 h
Result:	Increased cell population in the G2/M phase from 16.27 to 18.36, 23.46 and 31.51% at concentrations of 20 nM for12, 24 and 36 h. Increased average cell population in the G2/M phase from 16.27 to 28.07% at concentrations of 4, 20 and 100 nM for 24 h. Significantly decreased the protein expression levels of total CDK1 and phosphorylated CDK1.

Apoptosis Analysis^[3]

Cell Line:	HeLa cells
Concentration:	20 nM, 100 nM, 500 nM
Incubation Time:	48 h
Result:	Upregulated Bax expression and unaltered Bcl-2 expression. Significantly increased the expression of cytochrome c.

體內(nèi)研究
(In Vivo)

Digitoxin (1-2 mg/kg, Intraperitoneal injection, once a day for 19 days) 在裸鼠中具有抗癌作用^[3]。
Digitoxin (0.3-3 μg/kg, Intraperitoneal injection, once a day for 4 days) 阻斷棉花鼠肺內(nèi)宿主細(xì)胞因子的過度產(chǎn)生^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	nude mice harboring HeLa tumor xenografts^[3]
Dosage:	1 mg/kg, 2 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Decreased the tumor volume from 330.71±45.61 to 214.56.93±73.25 mm. Strongly increased the protein levels of cleaved caspase-3. Reduced the number of Ki-67-positive cells.

Animal Model:	cotton rats^[4]
Dosage:	0.3 μg/kg, 1 μg/kg, 3 μg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Blocked cytokine storm. Differentially affected cytokine expression. Left immune cell density intact in virus-infected lung.

Clinical Trial

分子量

764.94

Formula

C₄₁H₆₄O₁₃

CAS 號(hào)

71-63-6

性狀

固體

顏色

White to off-white

中文名稱

地高辛EP雜質(zhì)A)

結(jié)構(gòu)分類

Steroids

初始來源

微生物

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性數(shù)據(jù)

細(xì)胞實(shí)驗(yàn)：

DMSO 中的溶解度 : 100 mg/mL (130.73 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	1.3073 mL	6.5365 mL	13.0729 mL
5 mM	0.2615 mL	1.3073 mL	2.6146 mL
10 mM	0.1307 mL	0.6536 mL	1.3073 mL

查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

摩爾計(jì)算器
稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動(dòng)物實(shí)驗(yàn)：

請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

方案一

請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.27 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水定容至 1 mL。
生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
方案二

請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.27 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液中，混合均勻。
2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
方案三

請(qǐng)依序添加每種溶劑： 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.27 mM); 澄清溶液

此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液，此方案實(shí)驗(yàn)周期在半個(gè)月以上的動(dòng)物實(shí)驗(yàn)酌情使用。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL玉米油中，混合均勻。

動(dòng)物溶解方案計(jì)算器

請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只

由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量

請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：

DMSO +

Tween-80 +

Saline

如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。

方案所需 助溶劑 包括：DMSO，，均可在 MCE 網(wǎng)站選購(gòu)。，Tween 80，均可在 MCE 網(wǎng)站選購(gòu)。

計(jì)算結(jié)果

工作液所需濃度 : mg/mL

儲(chǔ)備液配制方法 : mg 藥物溶于 μL DMSO（母液濃度為 mg/mL）。

您所需的儲(chǔ)備液濃度超過該產(chǎn)品的實(shí)測(cè)溶解度，以下方案僅供參考，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。

動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。

連續(xù)給藥周期超過半月以上，請(qǐng)謹(jǐn)慎選擇該方案。

請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱（超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。

純度 & 產(chǎn)品資料

純度: 99.36%

選擇批次：

Data Sheet (642 KB) SDS (644 KB)

COA (288 KB) HNMR (329 KB) LCMS (253 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Arispe N, et al. Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channels [J]. Proceedings of the National Academy of Sciences, 2008, 105(7): 2610-2615. [Content Brief]

[2]. Su C T, Hsu J T A, Hsieh H P, et al. Anti-HSV activity of digitoxin and its possible mechanisms [J]. Antiviral research, 2008, 79(1): 62-70.

[3]. Gan H, Qi M, Chan C, et al. Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arrest and apoptosis in vitro and in vivo [J]. International Journal of Oncology, 2020, 57(2): 562-573.

[4]. Pollard B S, Blanco J C, Pollard J R. Classical drug digitoxin inhibits influenza cytokine storm, with implications for COVID-19 therapy [J]. in vivo, 2020, 34(6): 3723-3730.

[5]. Haux J. Digitoxin is a potential anticancer agent for several types of cancer [J]. Medical hypotheses, 1999, 53(6): 543-548.

Digitoxin 相關(guān)分類

完整儲(chǔ)備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3073 mL	6.5365 mL	13.0729 mL	32.6823 mL
	5 mM	0.2615 mL	1.3073 mL	2.6146 mL	6.5365 mL
	10 mM	0.1307 mL	0.6536 mL	1.3073 mL	3.2682 mL
	15 mM	0.0872 mL	0.4358 mL	0.8715 mL	2.1788 mL
	20 mM	0.0654 mL	0.3268 mL	0.6536 mL	1.6341 mL
	25 mM	0.0523 mL	0.2615 mL	0.5229 mL	1.3073 mL
	30 mM	0.0436 mL	0.2179 mL	0.4358 mL	1.0894 mL
	40 mM	0.0327 mL	0.1634 mL	0.3268 mL	0.8171 mL
	50 mM	0.0261 mL	0.1307 mL	0.2615 mL	0.6536 mL
	60 mM	0.0218 mL	0.1089 mL	0.2179 mL	0.5447 mL
	80 mM	0.0163 mL	0.0817 mL	0.1634 mL	0.4085 mL
	100 mM	0.0131 mL	0.0654 mL	0.1307 mL	0.3268 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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