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  2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Protoporphyrin IX

Protoporphyrin IX  (Synonyms: 原卟啉IX)

目錄號(hào): HY-B1247 純度: 98.46%
COA 產(chǎn)品使用指南

Protoporphyrin IX 是血紅素生物合成途徑中的最終中間體。Protoporphyrin IX 作為輻射敏化劑，即使在缺氧狀態(tài)下也能增強(qiáng) ROS 的生成并誘導(dǎo) DNA 損傷。Protoporphyrin IX 也作為光敏劑，通過(guò)光照射直接降解發(fā)生光漂白。Protoporphyrin IX 在給藥 5-aminolevulinic acid (5-ALA) (HY-W000450) 后在大鼠腫瘤細(xì)胞中形成和積累。當(dāng)激活峰值波長(zhǎng)為 405 nm 的紅色熒光時(shí)，Protoporphyrin IX 引起基底細(xì)胞癌的選擇性改善。Protoporphyrin IX 有望用于聲動(dòng)力和光動(dòng)力對(duì)癌癥的藥物研究，如膀胱癌和結(jié)節(jié)性基底細(xì)胞癌。

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Protoporphyrin IX Chemical Structure

Protoporphyrin IX Chemical Structure

CAS No. : 553-12-8

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    Protoporphyrin IX purchased from MCE. Usage Cited in: Genome Biol. 2022 Dec 15;23(1):259.  [Abstract]

    Protoporphyrin IX (PpIX; 0, 5, 15, 25 μM; 2 h) rapidly results in increased nuclear G4 levels in HeLa cells. Immunostaining of G4 using BG4-EGFP (green). The nuclei are stained with DAPI (blue).

    Protoporphyrin IX purchased from MCE. Usage Cited in: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jul;27(7):568-73.  [Abstract]

    To determine whether the inhibition of caveolin-1 tyrosine residues 14 ( Cav-1-Y14 ) phosphorylation with protein tyrosine kinase inhibitors ( PP2 ) will upregulate heme oxygenase-1 ( HO-1 ) activity to protect against ventilation induced lung injury in vivo of an animal model. The group D1 or D2 receive high tidal volume ventilation for 1 hour or 2 hour respectively, but they are given PP2 1 hour before high tidal volume ventilation. The groups E1 and E2 also receive high tidal volume ventilat

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Protoporphyrin IX is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma[1][2][3][4][5].

    IC50 & Target

    Human Endogenous Metabolite

     

    體外研究
    (In Vitro)

    Aminolevulinic acid (HY-W000450) (40 mg/kg, 口服, 單次給藥) 在五種淺表性、結(jié)節(jié)性和形態(tài)型基底細(xì)胞癌中產(chǎn)生全層Protoporphyrin IX 熒光[3]。
    Protoporphyrin IX (3.6 nmol/g 組織) 組織在光照下能引起正常大鼠結(jié)腸黏膜壞死[4]。
    Protoporphyrin IX (6.6 nmol/g 腫瘤) 在大鼠腫瘤輻照后延緩腫瘤生長(zhǎng)[4]。
    Protoporphyrin IX (0-25 μM, 2 小時(shí)) 迅速導(dǎo)致 Hela 細(xì)胞中核 G4 水平升高[5]。< br / >

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Immunofluorescence[3]

    Cell Line: Basal cell carcinoma
    Concentration:
    Incubation Time: 4-6 h
    Result: Protoporphyrin IX fluorescence was greater at the periphery of large tumor lobules than in the center and smaller lobules fluoresced uniformly in nodular tumors.
    體內(nèi)研究
    (In Vivo)

    Aminolevulinic acid (300 mg/kg, 單次靜脈注射) 給藥 3 小時(shí)后，大鼠肝臟和腸道中 Protoporphyrin IX 含量最高 (約 6.3 nmol/g 組織)，其次是主動(dòng)脈 (4.3 nmol/g 組織) 和食道 (2.1 nmol/g 組織)[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    562.66

    Formula

    C34H34N4O4
    CAS 號(hào)
    性狀

    固體

    顏色

    Brown to black

    中文名稱

    原卟啉IX
    結(jié)構(gòu)分類
    初始來(lái)源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 1 year; -20°C, 6 months (protect from light, stored under nitrogen)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 2 mg/mL (3.55 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

    Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 1.7773 mL 8.8864 mL 17.7727 mL
    5 mM --- --- ---
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months (protect from light, stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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    動(dòng)物溶解方案計(jì)算器
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    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    純度 & 產(chǎn)品資料

    純度: 98.46%

    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months (protect from light, stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7773 mL 8.8864 mL 17.7727 mL 44.4318 mL
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    產(chǎn)品名稱：
    Protoporphyrin IX
    目錄號(hào)：
    HY-B1247
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