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  2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Pronethalol hydrochloride

Pronethalol hydrochloride  (Synonyms: (±)-Pronethalo hydrochloride)

目錄號: HY-B1238A
產(chǎn)品使用指南

Pronethalol ((±)-Pronethalo) 是一種非選擇性的 β-腎上腺素 (β-adrenergic) 拮抗劑。 Pronethalol 是有效的 Sox2 表達抑制劑。Pronethalol 可預防和逆轉(zhuǎn)洋地黃引起的室性心律失常，也可以限制腦動靜脈畸形 (AVMs)。

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Pronethalol hydrochloride Chemical Structure

Pronethalol hydrochloride Chemical Structure

CAS No. : 51-02-5

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Pronethalol hydrochloride 的其他形式現(xiàn)貨產(chǎn)品:

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Other Forms of Pronethalol hydrochloride:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

查看 Adrenergic Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].

IC50 & Target

β adrenergic receptor

 

體外研究
(In Vitro)

Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces Sox2 expression to less than 10% after 2 days of treatment[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp–/– mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

265.78

Formula

C15H20ClNO
CAS 號
中文名稱

鹽酸普羅納賽洛；鹽酸丙萘洛爾
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻

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  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Pronethalol hydrochloride
目錄號：
HY-B1238A
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