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  2. Anti-infection Apoptosis Autophagy
  3. Bacterial Antibiotic Apoptosis Autophagy
  4. Nitroxoline

Nitroxoline  (Synonyms: 硝羥喹啉; 8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol)

目錄號: HY-B1159 純度: 99.90%
COA 產(chǎn)品使用指南 技術支持

Nitroxoline (8-Hydroxy-5-nitroquinoline) 是一種抗生素，是一種具有口服活性的抗生物膜劑。Nitroxoline 通過鐵和鋅的螯合減少銅綠假單胞菌生物膜的形成并誘導其分散。Nitroxoline 可用于尿路感染和癌癥研究。

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Nitroxoline Chemical Structure

Nitroxoline Chemical Structure

CAS No. : 4008-48-4

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥110
In-stock
500 mg ￥100
In-stock
1 g ￥160
In-stock
5 g   詢價  
10 g   詢價  

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Customer Review

Other Forms of Nitroxoline:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research[1][2][3].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
BTI-TN-5B1-4 IC50
55 nM
Compound: 10; APL-1202
Inhibition of recombinant human N-terminal His-tagged MetAP2 expressed in baculovirus infected BTI-TN-5B1-4 insect cells using Met-Pro-pNA as substrate preincubated for 20 mins followed by substrate addition and measured after 30 mins
Inhibition of recombinant human N-terminal His-tagged MetAP2 expressed in baculovirus infected BTI-TN-5B1-4 insect cells using Met-Pro-pNA as substrate preincubated for 20 mins followed by substrate addition and measured after 30 mins
[PMID: 30939017]
HUVEC IC50
1.9 μM
Compound: 10; APL-1202
Antiproliferative activity against HUVEC measured after 24 hrs by [3H]-thymidine incorporation assay
Antiproliferative activity against HUVEC measured after 24 hrs by [3H]-thymidine incorporation assay
[PMID: 30939017]
HUVEC IC50
283 μg/mL
Compound: 4a
Cytotoxicity against human HUVEC cells assessed as metabolic activity measured after 24 hrs by cell-titer blue assay
Cytotoxicity against human HUVEC cells assessed as metabolic activity measured after 24 hrs by cell-titer blue assay
[PMID: 34865870]
MV4-11 IC50
0.98 μM
Compound: 11
Inhibition of BRD4 in human MV4-11 cells using biotin labelled N-C:SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K as substrate preincubated for 15 mins followed by substrate addition measured after 5 mins by alpha screen assay
Inhibition of BRD4 in human MV4-11 cells using biotin labelled N-C:SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K as substrate preincubated for 15 mins followed by substrate addition measured after 5 mins by alpha screen assay
[PMID: 30529546]
MV4-11 IC50
4.9 μM
Compound: 11
Antiproliferative activity against human MV4-11 cells after 72 hrs by CellTiter Glo luminescent assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by CellTiter Glo luminescent assay
[PMID: 30529546]
體外研究
(In Vitro)

在銅綠假單胞菌中，Nitroxoline (0.25-16 μg/mL) 濃度下，生物膜質(zhì)量合成減少高達 80%，并且形成的結構是網(wǎng)狀的而不是致密的。在預先形成的生物膜中，治療濃度下活細胞計數(shù)減少 4 個對數(shù)[1]。
Nitroxoline (2.5-20 μM；24 小時) 可有效抑制小細胞肺癌 (SCLC) 細胞的存活，并通過抑制抗凋亡蛋白（如 Bcl-2 和 MCL1）和上調(diào)促凋亡蛋白 Bim 誘導 SCLC 細胞凋亡。研究發(fā)現(xiàn) Nitroxoline 通過誘導蛋白酶體降解來下調(diào) MDM2 表達，從而上調(diào) MDM2 底物蛋白 p53 的表達[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: H446, H1882, H1417, and H1688 cells
Concentration: 2.5 μM, 5 μM, 10 μM, 20 μM
Incubation Time: 24 hours
Result: Effectively inhibit cell survival of small-cell lung cancer (SCLC) cells.

Western Blot Analysis[2]

Cell Line: H446, H1882, H1417 cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 24 hours
Result: Suppressed antiapoptotic proteins (such as Bcl-2 and MCL1) and upregulated proapoptotic protein Bim.
體內(nèi)研究
(In Vivo)

Nitroxoline (15-60mg/kg；口服灌胃) 可顯著抑制 C3H/He 小鼠膀胱癌皮下模型中的腫瘤生長[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H/He mice bladder injected with MBT-2 cells[3]
Dosage: 15 mg/kg or 60mg/kg
Administration: Orally gavage; five times a week on days 1, 2, 4, 5, 7, 8, 10, and 11.
Result: Resulted in significant inhibition of tumor growth.
分子量

190.16

Formula

C9H6N2O3
CAS 號
性狀

固體

顏色

Light yellow to green yellow

中文名稱

硝羥喹啉
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 50 mg/mL (262.94 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 5.2587 mL 26.2936 mL 52.5873 mL
5 mM 1.0517 mL 5.2587 mL 10.5175 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.90%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2587 mL 26.2936 mL 52.5873 mL 131.4682 mL
5 mM 1.0517 mL 5.2587 mL 10.5175 mL 26.2936 mL
10 mM 0.5259 mL 2.6294 mL 5.2587 mL 13.1468 mL
15 mM 0.3506 mL 1.7529 mL 3.5058 mL 8.7645 mL
20 mM 0.2629 mL 1.3147 mL 2.6294 mL 6.5734 mL
25 mM 0.2103 mL 1.0517 mL 2.1035 mL 5.2587 mL
30 mM 0.1753 mL 0.8765 mL 1.7529 mL 4.3823 mL
40 mM 0.1315 mL 0.6573 mL 1.3147 mL 3.2867 mL
50 mM 0.1052 mL 0.5259 mL 1.0517 mL 2.6294 mL
60 mM 0.0876 mL 0.4382 mL 0.8765 mL 2.1911 mL
80 mM 0.0657 mL 0.3287 mL 0.6573 mL 1.6434 mL
100 mM 0.0526 mL 0.2629 mL 0.5259 mL 1.3147 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Nitroxoline
目錄號：
HY-B1159
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