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  2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis HDAC
  4. Triacetin

Triacetin  (Synonyms: 三醋酸甘油酯; Glyceryl triacetate; 1,2,3-Triacetoxypropane)

目錄號(hào): HY-B0896 純度: 99.58%
COA 產(chǎn)品使用指南 技術(shù)支持

Triacetin是一種人工合成的化合物，是甘油和乙酸的三酯。

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Triacetin Chemical Structure

Triacetin Chemical Structure

CAS No. : 102-76-1

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥110
In-stock
100 mg ￥100
In-stock
500 mg ￥150
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1 g ￥200
In-stock
5 g ￥320
In-stock
10 g   詢價(jià)  
50 g   詢價(jià)  

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Other Forms of Triacetin:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Triacetin (Glyceryl triacetate) is a synthetic compound that is a triester of glycerol and acetic acid. Triacetin increases acetate bioavailability in glioma cells. Triacetin induces glioma cell growth arrest and Apoptosis. Triacetin freely crosses the blood brain barrier/plasma membrane. Triacetin increases histone acetylation and enhances Temozolomide (HY-17364) (TMZ) chemotherapeutic efficacy [1][2].

IC50 & Target

Human Endogenous Metabolite

 

體外研究
(In Vitro)

Triacetin (0.25%, 24 h) 在體外誘導(dǎo) HOG, Hs683, U87, U251, OG33, OG35 GBM9, GBM12, GBM34, GBM2, GBM8 和 GBM44 細(xì)胞生長(zhǎng)停滯[1]。
Triacetin (25 mM, 24 h) 可有效抑制 U87MG (人類惡性膠質(zhì)瘤) 細(xì)胞活力[2]。
Triacetin (12.5-25 mM, 24 h) 在 U87MG 細(xì)胞中誘導(dǎo)明顯的 G2/M 細(xì)胞周期阻滯[2]。
Triacetin (12.5 mM) 誘導(dǎo) GBM 癌癥細(xì)胞凋亡[2]。
Triacetin (25 mM, 24 h) 降低 U87MG 細(xì)胞中 I類 和 II 類 HDAC (組蛋白脫乙酰酶) mRNA 的表達(dá)[2]。
Triacetin (12.5 mM, 24 h) 抑制 U87MG 細(xì)胞中 HDAC-8 的活性[2]。
Triacetin (12.5 mM, 24 h) 激活 mTOR 復(fù)合物下游基因，這些基因在癌癥細(xì)胞代謝中起重要作用，如S6K1，mSIN1，Protor 2 和 PKCα[2]。
Triacetin (12.5 mM, 24 h) 促進(jìn)有腫瘤抑制作用的 miRs 表達(dá)，這些 miRs 可以抑制 U87MG 細(xì)胞的生長(zhǎng)，增殖，侵襲，遷移和血管生成[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Human malignant glioma (U87 MG) cells
Concentration: 25 mM
Incubation Time: 24 h
Result: Inhibited the U87MG cell viability.

Cell Cycle Analysis[1]

Cell Line: Established glioma cell lines and primary tumor-derived GSCs.
Concentration: 0.25%
Incubation Time: 24 h
Result: Induced G0 growth arrest of all glioma cells, except U87, U251 and GBM (glioblastoma) 8 GSCs, without affecting Oli-Neu OPCs (oligodendrocyte progenitor cell line) or astrocytes and promoted NSC (neural stem cells) expansion.
The growth reduction of established glioma cell lines and primary tumor-derived GSCs in vitro is not due to the promotion of differentiation.

Cell Cycle Analysis[2]

Cell Line: U87 MG cells
Concentration: 12.5, 25 mM
Incubation Time: 24 h
Result: Induced 12% and 25% of sub-G1 cells and 60% and 79% of G2/M cells.

Apoptosis Analysis[2]

Cell Line: GBM cancer cells
Concentration: 12.5 mM
Incubation Time: 24 h
Result: Increased caspase-3 activity in treated GBM cancer cells.

RT-PCR[2]

Cell Line: U87MG cells
Concentration: 25 mM
Incubation Time: 24 h
Result: Decreased the classI and class II HDAC (histone deacetylase) mRNA expression.
Increased expression of S6K1, mSIN1, Protor 2, and PKCα.
Increased expression of miR-15b, miR-92, miR-101, miR-155, miR-199, miR-200, miR-223, and slight increase in expression in miR-16 and miR-17.
體內(nèi)研究
(In Vivo)

Triacetin (5.0 g/kg with 10% v/v oral-sweet SF, p.o., daily, 14 days) 可增強(qiáng)植入少突膠質(zhì)瘤 GSCs 小鼠 TMZ (Temozolomide) (HY-17364) 化療療效[1]。
Triacetin (5.0 g/kg with 10% v/v Ora-Sweet SF, p.o., daily, 40days) 可提高原位植入 GBM GSCs 小鼠的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult (8 week, 24 - 28g) male athymic mice orthotopically engrafted with oligodendroglioma-derived GSC cells [1].
Dosage: 5.0 g/kg with 10% v/v oral-sweet SF
Administration: p.o., daily, 14 days
Result: Significantly reduced tumor bioluminescence and increased survival but did not reduce end-point tumor volume with treatment of TMZ (Temozolomide) (HY-17364).
Animal Model: Adult (8 week, 24 - 28g) male athymic mice orthotopically engrafted with GBM-derived GSC cells[1].
Dosage: 5.0 g/kg with 10% v/v oral-sweet SF
Administration: p.o., daily, 40 days
Result: Alone did not alter blood glucose, bioluminescence, or end-point tumor volume; however, increased survival.
Significantly increased survival with treatment of TMZ, with two of eight mice never redeveloping measurable flux or displaying histological signs of tumor at study termination.
分子量

218.20

Formula

C9H14O6
CAS 號(hào)
性狀

液體（密度：1.16 g/cm3）

顏色

Colorless to light yellow

中文名稱

三醋精；三醋酸甘油酯；三醋汀；三乙酸丙酯；三乙酸甘油酯；甘油三乙酸酯
結(jié)構(gòu)分類
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : ≥ 2.3 mg/mL (10.54 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 4.5830 mL 22.9148 mL 45.8295 mL
5 mM 0.9166 mL 4.5830 mL 9.1659 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5830 mL 22.9148 mL 45.8295 mL 114.5738 mL
5 mM 0.9166 mL 4.5830 mL 9.1659 mL 22.9148 mL
10 mM 0.4583 mL 2.2915 mL 4.5830 mL 11.4574 mL
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