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  2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Ebastine

Ebastine  (Synonyms: 依巴斯汀; LAS-W 090; RP64305)

目錄號: HY-B0674 純度: 99.67%
COA 產(chǎn)品使用指南 技術(shù)支持

Ebastine (LAS-W 090) 是一種具有口服活性的第二代組胺 H1 受體 (histamine H1 receptor) 拮抗劑。Ebastine 可用于過敏性鼻炎的癥狀和慢性特發(fā)性蕁麻疹的研究。

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Ebastine Chemical Structure

Ebastine Chemical Structure

CAS No. : 90729-43-4

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥605
In-stock
500 mg ￥550
In-stock
1 g ￥700
In-stock
5 g ￥2000
In-stock
10 g   詢價  
50 g   詢價  

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Other Forms of Ebastine:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

查看 Histamine Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research[1].

IC50 & Target[1]

H1 Receptor

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
9.56 μM
Compound: Ebastine
Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
Inhibition of Ebolavirus glycoprotein/matrix protein VP40 entry in human HeLa cells after 4.5 hrs beta-lactamase reporter assay
[PMID: 29624387]
Vero CC50
15.42 μM
Compound: Ebastine
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
10.1101/2020.03.20.999730
Vero IC50
6.92 μM
Compound: Ebastine
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
10.1101/2020.03.20.999730
體外研究
(In Vitro)

Ebastine (10-500 ng/mL; 24-48 hours) treatment significantly increases the proliferation of HFDPC[2].
Ebastine (10-500 ng/mL; 24-48 hours) treatment shows dose-dependent increases in Cyclin D1, Cyclin E1, and Cyclin A expression levels. And the expression levels of Cdk4, Cdk2, and Cdc2 are alos increased. Ebastine treatment elevates expression levels of phospho-AKT and phospho-p44/42 extracellular signal-regulated kinase[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human follicle dermal papilla cells (HFDPC)
Concentration: 10 ng/mL, 50 ng/mL, 100 ng/mL, 200 ng/mL, 500 ng/mL
Incubation Time: 24 hours, 48 hours
Result: The proliferative activity in cells was significantly enhanced.

Western Blot Analysis[2]

Cell Line: Human follicle dermal papilla cells (HFDPC)
Concentration: 10 ng/mL, 50 ng/mL, 100 ng/mL, 200 ng/mL, 500 ng/mL
Incubation Time: 24 hours
Result: The expression levels of cell-cycle regulatory proteins and an antiapoptotic protein were increased in HFDPC.
體內(nèi)研究
(In Vivo)

In rats, after intravenous administration of [14C]Ebastine at 2 mg/kg, the plasma level of radioactivity decreased biphasically with α-phase half-life (t1/2 α) of 1.6 h and β-phase half-life (t1/2 β) of 3.1 h[3].
Following oral administration of [14C]Ebastine at a dose of 2 mg/kg, the plasma level reached the maximum (Cmax) of 102 ng eq./ml at 2 h and decreased monophasically with t1/2 of 3.9 h. At 20 mg/kg, a monophasic decrease is also observed with Cmax of 1110 ng eq./ml at 4 h and with t1/2 of 4.0 h[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

469.66

Formula

C32H39NO2
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

依巴斯汀；艾巴斯啶
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實驗： 

Ethanol 中的溶解度 : 58.75 mg/mL (125.09 mM; 超聲助溶)

DMSO 中的溶解度 : 8.33 mg/mL (17.74 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.1292 mL 10.6460 mL 21.2920 mL
5 mM 0.4258 mL 2.1292 mL 4.2584 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 2.1292 mL 10.6460 mL 21.2920 mL 53.2300 mL
5 mM 0.4258 mL 2.1292 mL 4.2584 mL 10.6460 mL
10 mM 0.2129 mL 1.0646 mL 2.1292 mL 5.3230 mL
15 mM 0.1419 mL 0.7097 mL 1.4195 mL 3.5487 mL
Ethanol 20 mM 0.1065 mL 0.5323 mL 1.0646 mL 2.6615 mL
25 mM 0.0852 mL 0.4258 mL 0.8517 mL 2.1292 mL
30 mM 0.0710 mL 0.3549 mL 0.7097 mL 1.7743 mL
40 mM 0.0532 mL 0.2661 mL 0.5323 mL 1.3307 mL
50 mM 0.0426 mL 0.2129 mL 0.4258 mL 1.0646 mL
60 mM 0.0355 mL 0.1774 mL 0.3549 mL 0.8872 mL
80 mM 0.0266 mL 0.1331 mL 0.2661 mL 0.6654 mL
100 mM 0.0213 mL 0.1065 mL 0.2129 mL 0.5323 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Ebastine
目錄號：
HY-B0674
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