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  2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel Anti-infection Autophagy
  3. Dopamine Receptor Adrenergic Receptor CaMK P-glycoprotein Influenza Virus Autophagy
  4. Trifluoperazine dihydrochloride

Trifluoperazine dihydrochloride  (Synonyms: 鹽酸三氟拉嗪)

目錄號(hào): HY-B0532A 純度: 99.90%
COA 產(chǎn)品使用指南 技術(shù)支持

Trifluoperazine dihydrochloride 是一種抗精神病藥物，通過(guò)阻斷中樞多巴胺受體 (dopamine receptors) 起作用。Trifluoperazine dihydrochloride 是一種有效的 α1-adrenergic 受體拮抗劑。Trifluoperazine dihydrochloride 是一種有效的 NUPR1 抑制劑，具有抗癌活性。Trifluoperazine dihydrochloride是一種鈣調(diào)蛋白 (calmodulin) 抑制劑，還可抑制 P-糖蛋白 (P-glycoprotein)，可用于精神分裂癥的研究。Trifluoperazine dihydrochloride 是流感病毒 (influenza virus) 形態(tài)發(fā)生的可逆抑制劑。

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Trifluoperazine dihydrochloride Chemical Structure

Trifluoperazine dihydrochloride Chemical Structure

CAS No. : 440-17-5

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥425
In-stock
50 mg ￥218
In-stock
100 mg ￥300
In-stock
500 mg ￥700
In-stock
1 g   詢(xún)價(jià)  
5 g   詢(xún)價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of Trifluoperazine dihydrochloride:

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
KG-1a IC50
4.58 μM
Compound: TFP
Antiproliferative activity against human KG1a cells assessed as reduction in cell viability incubated for 2 days by MTT assay
Antiproliferative activity against human KG1a cells assessed as reduction in cell viability incubated for 2 days by MTT assay
[PMID: 31541872]
MCF7 IC50
11.33 μM
Compound: TFP
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
[PMID: 31541872]
MDA-MB-231 IC50
21.58 μM
Compound: TFP
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
[PMID: 31541872]
NCI-H1650 GI50
12.2 μM
Compound: Trifluoperazine
Cytotoxicity against human NCI-H1650 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human NCI-H1650 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26372073]
Neutrophil IC50
12.2 μM
Compound: TFP
Antiinflammatory activity in fMLP/cytochalasin B stimulated rat neutrophils assessed as inhibition of beta-glucuronidase release preincubated for 10 mins measured 45 mins after fMLP/cytochalasin B challenge
Antiinflammatory activity in fMLP/cytochalasin B stimulated rat neutrophils assessed as inhibition of beta-glucuronidase release preincubated for 10 mins measured 45 mins after fMLP/cytochalasin B challenge
[PMID: 12662101]
Neutrophil IC50
13.2 μM
Compound: TFP
Antiinflammatory activity in fMLP/cytochalasin B stimulated rat neutrophils assessed as inhibition of lysozyme release preincubated for 10 mins measured 45 mins after fMLP/cytochalasin B challenge
Antiinflammatory activity in fMLP/cytochalasin B stimulated rat neutrophils assessed as inhibition of lysozyme release preincubated for 10 mins measured 45 mins after fMLP/cytochalasin B challenge
[PMID: 12662101]
NSC IC50
10.1 μM
Compound: TFP
Cytotoxicity against human NSC cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human NSC cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 29614416]
SK-BR-3 IC50
15.89 μM
Compound: TFP
Antiproliferative activity against human SKBR3 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
Antiproliferative activity against human SKBR3 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
[PMID: 31541872]
SUM-159-PT IC50
17.03 μM
Compound: TFP
Antiproliferative activity against human SUM159 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
Antiproliferative activity against human SUM159 cells assessed as reduction in cell viability incubated for 2 days by MTT assay
[PMID: 31541872]
U-87MG ATCC EC50
13.5 μM
Compound: TFP
Induction of intracellular Ca2+ level in human U87MG cells by Fura-2 AM dye-based assay
Induction of intracellular Ca2+ level in human U87MG cells by Fura-2 AM dye-based assay
[PMID: 29614416]
U-87MG ATCC IC50
9.9 μM
Compound: TFP
Cytotoxicity against human U87MG cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human U87MG cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 29614416]
體外研究
(In Vitro)

Trifluoperazine dihydrochloride is a long-established, widely used 'conventional' antipsychotic agent. Trifluoperazine dihydrochloride has been an extensively studied drug molecule that has been used as a calmodulin inhibitor[3][4].
Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis, but not budding, by disturbing cellular CaM and/or CaM-dependent functions[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

480.42

Formula

C21H26Cl2F3N3S
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱(chēng)

鹽酸三氟拉嗪；甲哌氟丙嗪；三氟吡拉嗪
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

H2O 中的溶解度 : 50 mg/mL (104.08 mM; 超聲助溶)

DMSO 中的溶解度 : 50 mg/mL (104.08 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.0815 mL 10.4076 mL 20.8151 mL
5 mM 0.4163 mL 2.0815 mL 4.1630 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶

  • 方案 一

    請(qǐng)依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.20 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請(qǐng)依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.20 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

    2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.98%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.0815 mL 10.4076 mL 20.8151 mL 52.0378 mL
5 mM 0.4163 mL 2.0815 mL 4.1630 mL 10.4076 mL
10 mM 0.2082 mL 1.0408 mL 2.0815 mL 5.2038 mL
15 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4692 mL
20 mM 0.1041 mL 0.5204 mL 1.0408 mL 2.6019 mL
25 mM 0.0833 mL 0.4163 mL 0.8326 mL 2.0815 mL
30 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
40 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3009 mL
50 mM 0.0416 mL 0.2082 mL 0.4163 mL 1.0408 mL
60 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.8673 mL
80 mM 0.0260 mL 0.1301 mL 0.2602 mL 0.6505 mL
100 mM 0.0208 mL 0.1041 mL 0.2082 mL 0.5204 mL

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

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產(chǎn)品名稱(chēng)：
Trifluoperazine dihydrochloride
目錄號(hào)：
HY-B0532A
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