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  1. Anti-infection
  2. Bacterial Antibiotic
  3. Amikacin hydrate

Amikacin hydrate  (Synonyms: 阿米卡星水合物; BAY 41-6551 hydrate)

目錄號(hào): HY-B0509 純度: 99.93%
COA 產(chǎn)品使用指南 技術(shù)支持

Amikacin hydrate (BAY 41-6551 hydrate) 是一種氨基糖苷類抗生素,也是一種卡那霉素的半合成類似物。Amikacin hydrate 具有殺菌作用,直接作用于 30S 和 50S 細(xì)菌核糖體亞基,可抑制蛋白質(zhì)合成。Amikacin hydrate 對(duì)大多數(shù)革蘭氏陰性細(xì)菌 (Gram-negative bacteria) (包括慶大霉素和妥布霉素抗性菌株) 非常有效。Amikacin hydrate 還抑制易感諾卡氏菌和非結(jié)核分枝桿菌引起的感染。

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Amikacin hydrate Chemical Structure

Amikacin hydrate Chemical Structure

CAS No. : 1257517-67-1

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10 mg ¥233
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25 mg ¥361
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50 mg ¥500
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100 mg ¥800
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500 mg ¥2000
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1 g   詢價(jià)  
5 g   詢價(jià)  

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Customer Review

Other Forms of Amikacin hydrate:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin hydrate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin hydrate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin hydrate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2].

IC50 & Target

Aminoglycoside

 

體外研究
(In Vitro)

Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi)[1].
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)研究
(In Vivo)

Amikacin (320?mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Fischer 344 rats (40-50-day-old)[3]
Dosage: 320?mg/kg
Administration: Subcutaneous injection; daily; for 10 days
Result: Induced hearing loss in rats.
Clinical Trial
Formula

C22H43N5O13.xH2O

CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

阿米卡星水合物; 丁胺卡那霉素水合物

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn): 

H2O 中的溶解度 : 50 mg/mL (超聲助溶)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息:

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

由于實(shí)驗(yàn)過(guò)程有損耗,建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳,請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度,如有需要,請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.93%

參考文獻(xiàn)

Amikacin hydrate 相關(guān)分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Amikacin hydrate
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