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  2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Tetracaine hydrochloride

Tetracaine hydrochloride  (Synonyms: 鹽酸丁卡因; Amethocaine hydrochloride)

目錄號: HY-B0473 純度: 99.91%
COA 產(chǎn)品使用指南 技術(shù)支持

Tetracaine hydrochloride (Amethocaine hydrochloride) 是一種鈣通道蛋白抑制劑，可阻斷肌漿網(wǎng)中Ca2+ 的電壓敏感釋放。Tetracaine hydrochloride 主要用于眼科和止癢藥。

該產(chǎn)品由公安部研究所生產(chǎn)，銷售、運輸全流程受嚴(yán)格監(jiān)管。MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，請您遵守承諾用途，不得違反法律法規(guī)規(guī)定用于任何其他用途。

Tetracaine hydrochloride Chemical Structure

Tetracaine hydrochloride Chemical Structure

CAS No. : 136-47-0

1.  客戶無需承擔(dān)相應(yīng)的運輸費用。

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3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
50 mg ￥100
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500 mg ￥200
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1 g ￥300
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10 g   詢價  

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Customer Review

Other Forms of Tetracaine hydrochloride:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic[1][2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 IC50
0.53 μM
Compound: tetracaine
Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.5 alpha subunit expressed in CHOK1 cells at -90 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
CHO-K1 IC50
1.1 μM
Compound: tetracaine
Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
0.11 μM
Compound: tetracaine
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
0.49 μM
Compound: Tetracaine
Inhibition of recombinant human Nav1.2 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
Inhibition of recombinant human Nav1.2 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
[PMID: 27015369]
HEK293 IC50
0.52 μM
Compound: Tetracaine
Inhibition of recombinant human Nav1.6 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
Inhibition of recombinant human Nav1.6 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
[PMID: 27015369]
HEK293 IC50
0.62 μM
Compound: tetracaine
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assay
Inhibition of recombinant human NaV1.7 alpha subunit expressed in HEK293 cells at -90 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
0.65 μM
Compound: Tetracaine
Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp method
Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp method
[PMID: 27015369]
HEK293 IC50
0.74 μM
Compound: Tetracaine
Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mins by FRET assay
[PMID: 27015369]
HEK293 IC50
33 μM
Compound: tetracaine
Inhibition of human NaV1.7 F1737A mutant expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
Inhibition of human NaV1.7 F1737A mutant expressed in HEK293 cells at -65 mV holding potential by patch clamp electrophysiological assay
[PMID: 22770500]
HEK293 IC50
7.51 μM
Compound: Tetracaine
Inhibition of human NaV1.7 expressed in HEK293 cells by [14C]guanidinium influx assay
Inhibition of human NaV1.7 expressed in HEK293 cells by [14C]guanidinium influx assay
[PMID: 21570288]
體外研究
(In Vitro)

Tetracaine hydrochloride (Amethocaine hydrochloride) 用于改變鈣釋放通道 (ryanodine 受體) 的功能，該通道控制細(xì)胞內(nèi)鈣的釋放。Tetracaine hydrochloride 是通道功能的變構(gòu)阻滯劑。在低濃度下，丁卡因最初會抑制自發(fā)鈣釋放事件，而在高濃度下，Tetracaine hydrochloride 會完全阻斷釋放[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

300.82

Formula

C15H25ClN2O2
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

鹽酸丁卡因；潘托卡因
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

溶解性數(shù)據(jù)
細(xì)胞實驗： 

H2O 中的溶解度 : 50 mg/mL (166.21 mM; 超聲助溶)

DMSO 中的溶解度 : ≥ 30 mg/mL (99.73 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.3242 mL 16.6212 mL 33.2425 mL
5 mM 0.6648 mL 3.3242 mL 6.6485 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.91%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.3242 mL 16.6212 mL 33.2425 mL 83.1062 mL
5 mM 0.6648 mL 3.3242 mL 6.6485 mL 16.6212 mL
10 mM 0.3324 mL 1.6621 mL 3.3242 mL 8.3106 mL
15 mM 0.2216 mL 1.1081 mL 2.2162 mL 5.5404 mL
20 mM 0.1662 mL 0.8311 mL 1.6621 mL 4.1553 mL
25 mM 0.1330 mL 0.6648 mL 1.3297 mL 3.3242 mL
30 mM 0.1108 mL 0.5540 mL 1.1081 mL 2.7702 mL
40 mM 0.0831 mL 0.4155 mL 0.8311 mL 2.0777 mL
50 mM 0.0665 mL 0.3324 mL 0.6648 mL 1.6621 mL
60 mM 0.0554 mL 0.2770 mL 0.5540 mL 1.3851 mL
80 mM 0.0416 mL 0.2078 mL 0.4155 mL 1.0388 mL
H2O 100 mM 0.0332 mL 0.1662 mL 0.3324 mL 0.8311 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Tetracaine hydrochloride
目錄號：
HY-B0473
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