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  2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Bethanechol

Bethanechol  (Synonyms: 貝膽堿; Carbamyl-β-methylcholine)

目錄號: HY-B0406
產(chǎn)品使用指南 技術(shù)支持

Bethanechol (Carbamyl-β-methylcholine) 是一種擬副交感神經(jīng)劑。Bethanechol 是毒蕈堿型受體 (mAChR) 的激動劑，通過直接刺激副交感神經(jīng)系統(tǒng)的 mAChR (M1、M2、M3、M4、M5) 發(fā)揮其作用。

在相同的摩爾濃度下，化合物鹽形式與游離形式有相同的生物活性，但鹽形式 Bethanechol chloride 通常具有更好的水溶性和穩(wěn)定性。

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Bethanechol Chemical Structure

Bethanechol Chemical Structure

CAS No. : 674-38-4

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Bethanechol 的其他形式現(xiàn)貨產(chǎn)品:

Other Forms of Bethanechol:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

查看 mAChR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Bethanechol (Carbamyl-β-methylcholine), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system[1].

IC50 & Target

mAChR[1]
體外研究
(In Vitro)

Bethanechol (0.3-300 μM) significantly reduces ileal pacemaker potentials[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Bethanechol (2-12 mg/kg; i.p.) induces drinking and increased urine output of rats in a dose-dependent fashion[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female rats of the Blue Spruce Farms (Sprague-Dawley) (280-330 g) [4]
Dosage: 2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg
Administration: Intraperitoneal injection
Result: Increased water intake during the first hr in a dose-dependent fashion up to the highest dose administered (12 mg/kg).
Clinical Trial
分子量

161.22

Formula

C7H17N2O2
CAS 號
中文名稱

貝膽堿
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目錄號：
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