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  1. Anti-infection Apoptosis Cell Cycle/DNA Damage
  2. Influenza Virus Orthopoxvirus SARS-CoV Apoptosis Bcl-2 Family CDK
  3. Amantadine hydrochloride

Amantadine hydrochloride  (Synonyms: 鹽酸金剛烷胺; 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride)

目錄號: HY-B0402A 純度: ≥98.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Amantadine (1-Adamantanamine) hydrochloride 是一種口服有效的抗甲型流感 (influenza A) 病毒的抗病毒劑。Amantadine hydrochloride 對 NMDAM2 等多種離子通道均有抑制作用。Amantadine hydrochloride 還具有抗正痘病毒 (orthopoxvirus) 和抗癌 活性。Amantadine hydrochloride 可用于帕金森病,術(shù)后認知功能障礙 (POCD) 和 COVID-19 的研究。

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Amantadine hydrochloride Chemical Structure

Amantadine hydrochloride Chemical Structure

CAS No. : 665-66-7

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10 mM * 1 mL in DMSO ¥330
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Customer Review

Other Forms of Amantadine hydrochloride:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].

IC50 & Target

CDK2

 

Bcl-2

 

Bax

 

體外研究
(In Vitro)

Amantadine hydrochloride (0-500 μM,26 小時) 抑制 SARS-CoV-2 復(fù)制,IC50 濃度在 83 和 119 μM 之間[4]。
Amantadine hydrochloride (0-100 μg/mL,24-72 h) 顯著抑制 HepG2 和 SMMC-7721 細胞的增殖[6]。
Amantadine hydrochloride (0-75 μg/mL,48 h) 將細胞周期阻滯在 G0/G1 期并誘導(dǎo)細胞凋亡[6]
Amantadine hydrochloride (0-75 μg/mL,48 h) 可降低細胞周期相關(guān)基因和蛋白 (cyclin D1、cyclin E 和 CDK2),減少 Bcl-2 并增加 Bax 蛋白和 mRNA 水平[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[4]

Cell Line: Vero E6 cells
Concentration: 500 μM, 100 μM, 20 μM, 4 μM, and 8 nM
Incubation Time: 26 h
Result: Caused a concentration-dependent reduction (IC50=83 μM) of viral nucleic acids in the supernatant 26 h after infection at 10-500 μM. Caused a concentration-dependent reduction (IC50=119 μM) of viral nucleic acids in the cytosol 26 h after infection.

Cell Proliferation Assay[6]

Cell Line: Human HCC cell lines (HepG2 and SMMC-7721) and normal hepatocellular cells (L02 cells)
Concentration: 0, 1, 2, 5, 10, 25, 50 and 100 μg/mL
Incubation Time: 24, 48 and 72 h
Result: Inhibited cellular proliferation in a time- and dose-dependent manner in HepG2 and SMMC-7721 cells.

Cell Cycle Analysis[6]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 0, 10, 25, 50 and 75 μg/mL
Incubation Time: 48 h
Result: Significantly increased the population of HepG2 and SMMC-7721 cells in the G0/G1 phase in a dose-dependent manner, and significantly decreased the number of HepG2 cells in the S phase.

Apoptosis Analysis[6]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 0, 10, 25, 50 and 75 μg/mL
Incubation Time: 48 h
Result: Markedly increased the percentage of apoptotic HepG2 and SMMC-7721 cells (early- and late-stage apoptosis) in a dose-dependent manner.

Western Blot Analysis[6]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 0, 10, 25, 50 and 75 μg/mL
Incubation Time: 48 h
Result: Showed downregulation of cyclin D1, cyclin E and CDK2, and showed a decrease in Bcl-2 levels and an increase of Bax levels in HepG2 and SMMC-7721 cells.

RT-PCR[6]

Cell Line: HepG2 and SMMC-7721 cells
Concentration: 0, 10, 25, 50 and 75 μg/mL
Incubation Time: 48 h
Result: Revealed an increase in Bax and decrease in Bcl-2 genes.
體內(nèi)研究
(In Vivo)

Amantadine hydrochloride (25 mg/kg,IP,每天一次,持續(xù) 3 天) 抑制手術(shù)引起的神經(jīng)炎癥和學(xué)習(xí)記憶障礙[5]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)[5]
Dosage: 25 mg/kg
Administration: IP, once daily for 3 days (the first dose at 15 min before surgery)
Result: Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.
Clinical Trial
分子量

187.71

Formula

C10H18ClN

CAS 號
性狀

固體

顏色

White to off-white

中文名稱

鹽酸金剛烷胺

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

Store at room temperature, keep dry and cool

In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗: 

DMSO 中的溶解度 : 100 mg/mL (532.74 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響,請使用新開封的 DMSO)

H2O 中的溶解度 : ≥ 50 mg/mL (266.37 mM)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 5.3274 mL 26.6368 mL 53.2737 mL
5 mM 1.0655 mL 5.3274 mL 10.6547 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效
儲備液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C儲存時,請在2年內(nèi)使用,-20°C儲存時,請在1年內(nèi)使用。

* 備注:如您選擇水作為儲備液,請稀釋至工作液后,再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗:

以下溶解方案,請直接配制工作液。建議現(xiàn)用現(xiàn)配,在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比; 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象,可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑: PBS

    Solubility: 6.88 mg/mL (36.65 mM); 澄清溶液; 超聲助溶 (<60°C)

動物溶解方案計算器
請輸入動物實驗的基本信息:

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

由于實驗過程有損耗,建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳,請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度,如有需要,請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效
儲備液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C儲存時,請在2年內(nèi)使用,-20°C儲存時,請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 5.3274 mL 26.6368 mL 53.2737 mL 133.1842 mL
5 mM 1.0655 mL 5.3274 mL 10.6547 mL 26.6368 mL
10 mM 0.5327 mL 2.6637 mL 5.3274 mL 13.3184 mL
15 mM 0.3552 mL 1.7758 mL 3.5516 mL 8.8789 mL
20 mM 0.2664 mL 1.3318 mL 2.6637 mL 6.6592 mL
25 mM 0.2131 mL 1.0655 mL 2.1309 mL 5.3274 mL
30 mM 0.1776 mL 0.8879 mL 1.7758 mL 4.4395 mL
40 mM 0.1332 mL 0.6659 mL 1.3318 mL 3.3296 mL
50 mM 0.1065 mL 0.5327 mL 1.0655 mL 2.6637 mL
60 mM 0.0888 mL 0.4439 mL 0.8879 mL 2.2197 mL
80 mM 0.0666 mL 0.3330 mL 0.6659 mL 1.6648 mL
100 mM 0.0533 mL 0.2664 mL 0.5327 mL 1.3318 mL

* 備注:如您選擇水作為儲備液,請稀釋至工作液后,再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱:
Amantadine hydrochloride
目錄號:
HY-B0402A
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