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  1. Membrane Transporter/Ion Channel Neuronal Signaling PI3K/Akt/mTOR Stem Cell/Wnt
  2. Calcium Channel GSK-3
  3. Cromolyn sodium

Cromolyn sodium  (Synonyms: 色甘酸鈉; Disodium Cromoglycate; FPL-670)

目錄號: HY-B0320A 純度: 99.93%
COA 產(chǎn)品使用指南

Cromolyn sodium (Disodium Cromoglycate; FPL-670) 是抗過敏化合物。Cromolyn sodium 是一種 GSK-3β 抑制劑,IC50 為 2.0 μM。

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Cromolyn sodium Chemical Structure

Cromolyn sodium Chemical Structure

CAS No. : 15826-37-6

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10 mM * 1 mL in DMSO ¥440
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Customer Review

Other Forms of Cromolyn sodium:

    Cromolyn sodium purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.  [Abstract]

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.
    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻

    生物活性

    Cromolyn sodium (Disodium Cromoglycate; FPL-670) is an antiallergic agent. Cromolyn sodium is a GSK-3β inhibitor with an IC50 of 2.0 μM.

    IC50 & Target

    GSK-3β

    2 μM (IC50)

    細胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    CHO EC50
    0.986 μM
    Compound: 2
    Agonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay
    Agonist activity at rat GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay
    [PMID: 23713606]
    CHO EC50
    1.26 μM
    Compound: 2
    Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay
    Agonist activity at human GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay
    [PMID: 23713606]
    CHO EC50
    4.84 μM
    Compound: 2
    Agonist activity at mouse GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay
    Agonist activity at mouse GPR35 expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase reporter gene assay
    [PMID: 23713606]
    LAD2 IC50
    > 1 mM
    Compound: DSCG
    Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay
    Inhibition of human LAD2 mast cell activation assessed as compound 48/80-induced degranulation incubated for 30 mins prior to compound 48/80 challenge by beta-hexosaminidase release assay
    [PMID: 23617679]
    Mast cell ED50
    2.55 μg/mL
    Compound: disodium cromoglycate
    Antianaphylactic activity in rat mast cells assessed as inhibition of DNP-ovalbumin-induced histamine release after 15 mins by superfusion assay
    Antianaphylactic activity in rat mast cells assessed as inhibition of DNP-ovalbumin-induced histamine release after 15 mins by superfusion assay
    [PMID: 82617]
    Mast cell IC50
    6.5 μM
    Compound: cromolyn sodium
    Antiallergic activity in rat peritoneal mast cells assessed as inhibition of ovalbumin-induced histamine release after 15 mins
    Antiallergic activity in rat peritoneal mast cells assessed as inhibition of ovalbumin-induced histamine release after 15 mins
    [PMID: 88523]
    RBL-2H3 IC50
    1540 μM
    Compound: DSCG
    Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge
    Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge
    [PMID: 14510616]
    體外研究
    (In Vitro)

    Cromolyn sodium (Disodium Cromoglycate; FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    體內(nèi)研究
    (In Vivo)

    Pretreatment of IIR mice with Cromolyn sodium (Disodium Cromoglycate; FPL-670) prior to ischemia exhibited no changes of ET-1 levels, injury score and inflammation (P>0.05, PreCr vs. M groups). In conclusion, administration of Cromolyn (sodium) after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressing sustained MC activation[1]. Cromolyn (sodium) has a role in the prevention of Chronic lung disease(CLD). Cromolyn (sodium) cannot be recommended for the prevention of CLD in preterm infants[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    分子量

    512.33

    Formula

    C23H14Na2O11

    CAS 號
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    色甘酸鈉

    運輸條件

    Room temperature in continental US; may vary elsewhere.

    儲存方式

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 1 year; -20°C, 6 months (protect from light, stored under nitrogen)

    溶解性數(shù)據(jù)
    細胞實驗: 

    H2O 中的溶解度 : 50 mg/mL (97.59 mM; 超聲助溶)

    DMSO 中的溶解度 : 25 mg/mL (48.80 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響,請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 1.9519 mL 9.7593 mL 19.5187 mL
    5 mM 0.3904 mL 1.9519 mL 3.9037 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限:-80°C, 1 year; -20°C, 6 months (protect from light, stored under nitrogen)。-80°C儲存時,請在1年內(nèi)使用, -20°C儲存時,請在6個月內(nèi)使用。

    * 備注:如您選擇水作為儲備液,請稀釋至工作液后,再用 0.22 μm 的濾膜過濾除菌后使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實驗:

    請根據(jù)您的 實驗動物和給藥方式 選擇適當?shù)娜芙夥桨浮?

    以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液,再依次添加助溶劑:
    ——為保證實驗結果的可靠性,澄清的儲備液可以根據(jù)儲存條件,適當保存;體內(nèi)實驗的工作液,建議您現(xiàn)用現(xiàn)配,當天使用
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比;如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象,可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請依序添加每種溶劑: 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (4.88 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL(飽和度未知)的澄清溶液。

      1 mL 工作液為例,取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中,混合均勻。

      2 g SBE-β-CD(磺丁基醚 β-環(huán)糊精)粉末定容于 10 mL 的生理鹽水中,完全溶解至澄清透明。
    • 方案 二

      請依序添加每種溶劑: 10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (4.88 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL(飽和度未知)的澄清溶液,此方案實驗周期在半個月以上的動物實驗酌情使用。

      1 mL 工作液為例,取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL玉米油中,混合均勻。

    以下溶解方案,請直接配制工作液。建議現(xiàn)用現(xiàn)配,在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比; 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象,可以通過加熱和/或超聲的方式助溶。

    • 方案 一

      請依序添加每種溶劑: PBS

      Solubility: 50 mg/mL (97.59 mM); 澄清溶液; 超聲助溶

    動物溶解方案計算器
    請輸入動物實驗的基本信息:

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    由于實驗過程有損耗,建議您多配一只動物的量
    計算結果
    工作液所需濃度 : mg/mL
    該產(chǎn)品水溶性佳,請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
    您所需的儲備液濃度超過該產(chǎn)品的實測溶解度,如有需要,請與 MCE 中國技術支持聯(lián)系。
    純度 & 產(chǎn)品資料

    純度: 99.93%

    參考文獻

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限:-80°C, 1 year; -20°C, 6 months (protect from light, stored under nitrogen)。-80°C儲存時,請在1年內(nèi)使用, -20°C儲存時,請在6個月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 1.9519 mL 9.7593 mL 19.5187 mL 48.7967 mL
    5 mM 0.3904 mL 1.9519 mL 3.9037 mL 9.7593 mL
    10 mM 0.1952 mL 0.9759 mL 1.9519 mL 4.8797 mL
    15 mM 0.1301 mL 0.6506 mL 1.3012 mL 3.2531 mL
    20 mM 0.0976 mL 0.4880 mL 0.9759 mL 2.4398 mL
    25 mM 0.0781 mL 0.3904 mL 0.7807 mL 1.9519 mL
    30 mM 0.0651 mL 0.3253 mL 0.6506 mL 1.6266 mL
    40 mM 0.0488 mL 0.2440 mL 0.4880 mL 1.2199 mL
    H2O 50 mM 0.0390 mL 0.1952 mL 0.3904 mL 0.9759 mL
    60 mM 0.0325 mL 0.1627 mL 0.3253 mL 0.8133 mL
    80 mM 0.0244 mL 0.1220 mL 0.2440 mL 0.6100 mL

    * 備注:如您選擇水作為儲備液,請稀釋至工作液后,再用 0.22 μm 的濾膜過濾除菌后使用。

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    產(chǎn)品名稱:
    Cromolyn sodium
    目錄號:
    HY-B0320A
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