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  2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis Anti-infection
  3. Reactive Oxygen Species Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus
  4. Acetylcysteine

Acetylcysteine  (Synonyms: 乙酰半胱氨酸; N-Acetylcysteine; N-Acetyl-L-cysteine; NAC)

目錄號(hào): HY-B0215 純度: 99.81%
COA 產(chǎn)品使用指南 技術(shù)支持

Acetylcysteine (N-Acetylcysteine) 是一種粘液溶解劑 (mucolytic agent)，可用于減少粘液的厚度。Acetylcysteine 是一種 ROS 抑制劑。Acetylcysteine 是半胱氨酸前體，通過中和花生四烯酸依賴的5-脂氧合酶活性所產(chǎn)生的毒性脂質(zhì)來防止血紅素誘導(dǎo)的鐵中毒 (ferroptosis)。Acetylcysteine 可以誘導(dǎo)細(xì)胞凋亡 (apoptosis)，并具有抗流感病毒活性。此外，Acetylcysteine 是半胱氨酸在藥物輸送過程中最穩(wěn)定形式，可用于雙硫死亡 (disulfidptosis) 的研究。

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Acetylcysteine Chemical Structure

Acetylcysteine Chemical Structure

CAS No. : 616-91-1

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in Water ￥440
In-stock
500 mg ￥400
In-stock
5 g ￥500
In-stock
10 g ￥600
In-stock
50 g   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of Acetylcysteine:

MCE 顧客使用本產(chǎn)品發(fā)表的 406 篇科研文獻(xiàn)

WB

    Acetylcysteine purchased from MCE. Usage Cited in: Cell Death Discov. 2018 Apr 27;4:47.  [Abstract]

    Wild-type, Prx1KO, and Prx1OE cells are each divided into three groups, which are control groups, groups treated with 100?ng/mL LPS, and groups treated with 100?ng/mL LPS and NAC. Western blot analysis is then performed with antibodies against Bax, Bcl-2, Cyto-c, caspase 3, and GAPDH, and band intensity is measured with densitometry.

    Acetylcysteine purchased from MCE. Usage Cited in: Fundam Clin Pharmacol. 2017 Feb;31(1):64-74.  [Abstract]

    Advanced oxidation production product (AOPP)-triggered apoptosis-related signals are triggered by ROS production. Human chondrocytes are pretreated with N-Acetylcysteine (NAC; 5 mM) for 60 min, and then, chondrocyte are co-incubated with AOPP and NAC for 24 h. (a) Pretreatment of ROS scavenger NAC markedly alleviates AOPP-triggered mitochondria-mediated apoptosis proteins. (b) Pretreatment of chondrocyte with NAC abrogates the intracellular Ca2+ mobilization. (c) NAC pretreatment atte

    Acetylcysteine purchased from MCE. Usage Cited in: Sci Rep. 2016 Oct 27;6:35995.  [Abstract]

    Pretreatment of NAC, a free radical scavenger, largely decreases the expression of caspase-3 and almost abolishes the H2O2 induced upregulation of PRX1. Western blot analysis shows the pretreatment of osteoblast cells with E2 partially abrogates the increased PRX1 and caspase-3 expressions induced by H2O2.

    • 生物活性

    • 實(shí)驗(yàn)參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine ??is the most stable form of cysteine ??during drug delivery and can be used in disulfidptosis studies[1][2][3][4][5][6][7][8].

    IC50 & Target

    Human Endogenous Metabolite

     

    體外研究
    (In Vitro)

    Acetylcysteine 可防止凋亡 DNA 片段化，并在缺乏其他營養(yǎng)支持的情況下維持血清剝奪 PC12 細(xì)胞的長期存活。Acetylcysteine 還可防止 PC12 細(xì)胞和交感神經(jīng)元死亡[2]。
    Acetylcysteine 導(dǎo)致大鼠和人主動(dòng)脈平滑肌細(xì)胞的活力呈劑量依賴性降低[3]。
    Acetylcysteine 激活 PC12 細(xì)胞中的 Ras 細(xì)胞外信號(hào)調(diào)節(jié)激酶 (ERK) 通路。Acetylcysteine 保護(hù)神經(jīng)元細(xì)胞免于因營養(yǎng)支持撤消而引起的死亡。Acetylcysteine 增加血管組織中蛋白質(zhì)結(jié)合儲(chǔ)存的一氧化氮 (NO) 釋放。Acetylcysteine 預(yù)處理 PC12 細(xì)胞會(huì)干擾 NGF 依賴的信號(hào)傳導(dǎo)和神經(jīng)突的生長，提示 Acetylcysteine 會(huì)干擾 NGF 機(jī)制中的氧化還原敏感步驟[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Acetylcysteine (150，300 mg/kg) 處理顯著降低所有處理組的肝轉(zhuǎn)氨酶，主要是 Acetylcysteine 300 mg/kg 組。肺谷胱甘肽過氧化物酶在 Acetylcysteine 300 mg/kg 組中顯著增加 (P=0.04)，而其他氧化生物標(biāo)志物顯示無顯著性差異[6]。
    Acetylcysteine 改善 12 個(gè)月大的 SAMP8 小鼠在 T 迷宮電擊回避范例和杠桿按壓食欲任務(wù)中的認(rèn)知，而不會(huì)對(duì)運(yùn)動(dòng)產(chǎn)生非特異性影響活動(dòng)、避免電擊的動(dòng)機(jī)或體重[5]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    163.20

    Formula

    C5H9NO3S
    CAS 號(hào)
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    乙酰半胱氨酸
    結(jié)構(gòu)分類
    初始來源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    H2O 中的溶解度 : 100 mg/mL (612.75 mM; 超聲助溶)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 6.1275 mL 30.6376 mL 61.2753 mL
    5 mM 1.2255 mL 6.1275 mL 12.2551 mL
    查看完整儲(chǔ)備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

    * 備注：如您選擇水作為儲(chǔ)備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物實(shí)驗(yàn)：

    以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

    • 方案 一

      請依序添加每種溶劑： PBS

      Solubility: 120 mg/mL (735.30 mM); 澄清溶液; 超聲助溶

    動(dòng)物溶解方案計(jì)算器
    請輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    該產(chǎn)品水溶性佳，請具體參考實(shí)測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
    您所需的儲(chǔ)備液濃度超過該產(chǎn)品的實(shí)測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
    純度 & 產(chǎn)品資料

    純度: 99.81%

    參考文獻(xiàn)
    Cell Assay
    [2]

    For survival experiments, washed cells are resuspended in RPM1 1640 medium and plated in 0.5 mL at a density of 8-10×105 per well in 24 well plastic culture dishes coated with rat tail collagen. To feed, but to avoid loss of floating cells, fresh medium (0.2 mL) is added to the cultures on days 1, 5, and 10. For experiments involving "primed" PC12 cells, cultures are pretreated for l-2 weeks with NGF in RPM1 1640 medium supplemented with 1% heat-iN-acetylcysteinetivated horse serum. The cells are then washed and passaged into serum-free RPM1 1640 medium.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [6]

    Rats: Rats are randomLy allocated into five groups: sham group (n=5), control group with IIR (n=8) and three groups with IIR who are given Acetylcysteine in different dosages: 150?mg/kg intraperitoneally 5?min before ischemia (n=8, group Acetylcysteine 150), 300?mg/kg i.p 5?min before ischemia (n=7, group Acetylcysteine 300), and 150?mg/kg i.p 5?min before ischemia plus 150?mg/kg 5?min before reperfusion (n=7, group Acetylcysteine 150?+?150). After 4?h of reperfusion, the animals are euthanized by exsanguination from the abdominal aorta.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 6.1275 mL 30.6376 mL 61.2753 mL 153.1882 mL
    5 mM 1.2255 mL 6.1275 mL 12.2551 mL 30.6376 mL
    10 mM 0.6128 mL 3.0638 mL 6.1275 mL 15.3188 mL
    15 mM 0.4085 mL 2.0425 mL 4.0850 mL 10.2125 mL
    20 mM 0.3064 mL 1.5319 mL 3.0638 mL 7.6594 mL
    25 mM 0.2451 mL 1.2255 mL 2.4510 mL 6.1275 mL
    30 mM 0.2043 mL 1.0213 mL 2.0425 mL 5.1063 mL
    40 mM 0.1532 mL 0.7659 mL 1.5319 mL 3.8297 mL
    50 mM 0.1226 mL 0.6128 mL 1.2255 mL 3.0638 mL
    60 mM 0.1021 mL 0.5106 mL 1.0213 mL 2.5531 mL
    80 mM 0.0766 mL 0.3830 mL 0.7659 mL 1.9149 mL
    100 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5319 mL

    * 備注：如您選擇水作為儲(chǔ)備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

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    產(chǎn)品名稱：
    Acetylcysteine
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