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  2. 誘導(dǎo)疾病模型產(chǎn)品 Immunology/Inflammation Autophagy Anti-infection
  3. 免疫與炎癥疾病模型 皮膚疾病模型 Toll-like Receptor (TLR) Autophagy SARS-CoV HSV
  4. 銀屑病模型
  5. Imiquimod

Imiquimod  (Synonyms: 咪喹莫特; R 837)

目錄號(hào): HY-B0180 純度: 99.96%
COA 產(chǎn)品使用指南

Imiquimod (R 837) 是一種 toll 樣受體7 (TLR7) 激動(dòng)劑，作為一種免疫反應(yīng)修飾劑。Imiquimod 在體內(nèi)表現(xiàn)出抗病毒和抗腫瘤作用。Imiquimod 可用于外生殖器、肛周疣、癌癥和 COVID-19 的研究。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Imiquimod Chemical Structure

Imiquimod Chemical Structure

CAS No. : 99011-02-6

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mg ￥166
In-stock
25 mg ￥245
In-stock
50 mg ￥348
In-stock
100 mg ￥485
In-stock
200 mg ￥710
In-stock
500 mg ￥1213
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1 g ￥1788
In-stock
5 g   詢價(jià)  
10 g   詢價(jià)  

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Customer Review

Other Forms of Imiquimod:

MCE 顧客使用本產(chǎn)品發(fā)表的 38 篇科研文獻(xiàn)

WB

    Imiquimod purchased from MCE. Usage Cited in: Nat Commun. 2016 May 25;7:11724.  [Abstract]

    Freshly prepared splenic B cells are left unstimulated (lanes 1 and 4), or stimulated by 10?μg/mL αIgM for 6 or 24?h (lanes 2 and 3), or by 1?μg/mL IMQ for 6, 24, 48 and 72?h (lanes 5-8), or by αIgM and IMQ for 24 or 48?h (lanes 9+10), respectively.

    查看 Toll-like Receptor (TLR) 亞型特異性產(chǎn)品:

    查看 HSV 亞型特異性產(chǎn)品:

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

    IC50 & Target[1][3]

    TLR7

     

    HSV-1

     

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A-375 IC50
    70.3 μM
    Compound: Imiquimod
    Cytotoxicity against human A375 cells after 96 hrs by MTT assay
    Cytotoxicity against human A375 cells after 96 hrs by MTT assay
    		[PMID: 19278757]
    A-375 IC50
    70.3 μM
    Compound: imiquimod
    Cytotoxicity against human A375 cells after 96 hrs by MTT assay
    Cytotoxicity against human A375 cells after 96 hrs by MTT assay
    		[PMID: 18513976]
    HEK293 EC50
    > 270 μM
    Compound: 1
    Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay
    Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay
    		[PMID: 22837811]
    HEK293 EC50
    10.7 μM
    Compound: 1
    Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay
    Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay
    		[PMID: 24383475]
    HEK293 EC50
    12.1 μM
    Compound: 1
    Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay
    Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay
    		[PMID: 22837811]
    HEK293 EC50
    2.12 μM
    Compound: 1
    Agonist activity at human TLR7 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by reporter gene assay
    Agonist activity at human TLR7 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by reporter gene assay
    		[PMID: 20481492]
    HEK293 EC50
    6.2 μM
    Compound: 1
    Agonist activity at human TLR7 in HEK293 cells cotransfected with SEAP reporter gene assessed as activity of SEAP incubated for 24 hrs by quanti-blue staining based SEAP reporter gene assay
    Agonist activity at human TLR7 in HEK293 cells cotransfected with SEAP reporter gene assessed as activity of SEAP incubated for 24 hrs by quanti-blue staining based SEAP reporter gene assay
    		[PMID: 31247373]
    LS174T IC50
    34.4 μM
    Compound: imiquimod
    Cytotoxicity against human LS174T cells after 96 hrs by MTT assay
    Cytotoxicity against human LS174T cells after 96 hrs by MTT assay
    		[PMID: 18513976]
    MCF7 IC50
    145 μM
    Compound: imiquimod
    Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay
    Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay
    		[PMID: 18513976]
    Raji IC50
    139 μM
    Compound: imiquimod
    Cytotoxicity against human Raji cells after 96 hrs by MTT assay
    Cytotoxicity against human Raji cells after 96 hrs by MTT assay
    		[PMID: 18513976]
    體內(nèi)研究
    (In Vivo)

    Lmiquimod (IMQ) 可用于誘導(dǎo)銀屑病模型[5]。

    誘導(dǎo)銀屑病模型[5]
    致病原理
    Lmiquimod (IMQ) 可誘發(fā)類似于斑塊型銀屑病的發(fā)炎鱗狀皮膚病變。IMQ 誘導(dǎo)表皮表達(dá) IL-23、IL-17A 和 IL-17F，以及脾Th17 細(xì)胞的增加。
    具體造模方法：
    小鼠：BALB/c • 雄性 • 8 周齡
    給藥方式：3.125 mg/day • 局部用于皮膚 • 6 天
    Note
    造模成功指標(biāo)
    組織學(xué)改變: 誘導(dǎo)小鼠背部皮膚開(kāi)始出現(xiàn)紅斑、鱗屑和增厚跡象。
    導(dǎo)致角質(zhì)形成細(xì)胞過(guò)度增殖并擾亂表皮分化（角化不全）。
    相關(guān)產(chǎn)品： /
    拮抗產(chǎn)品： /

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: BALB/c mice (8-11 week) [5]
    Dosage: 3.125 mg/day, 6 day
    Administration: skin
    Result: Induced the back skin of the mice started to display signs of erythema, scaling, and thickening.
    Resulted in hyperproliferative keratinocytes and a disturbed epidermal differentiation (parakeratosis).
    Clinical Trial
    分子量

    240.30

    Formula

    C14H16N4
    CAS 號(hào)
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    咪喹莫特
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 3.28 mg/mL (13.65 mM; ultrasonic and warming and adjust pH to 7 with 1 M HCL and heat to 60°C; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

    H2O 中的溶解度 : 2.64 mg/mL (10.99 mM; 超聲助溶; 酸性條件溶解 (HCL 調(diào)節(jié)，pH≈2))

    Methanol 中的溶解度 : < 1 mg/mL (insoluble)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 4.1615 mL 20.8073 mL 41.6146 mL
    5 mM 0.8323 mL 4.1615 mL 8.3229 mL
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

    * 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物溶解方案計(jì)算器
    請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    純度 & 產(chǎn)品資料

    純度: 99.96%

    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 4.1615 mL 20.8073 mL 41.6146 mL 104.0366 mL
    5 mM 0.8323 mL 4.1615 mL 8.3229 mL 20.8073 mL
    10 mM 0.4161 mL 2.0807 mL 4.1615 mL 10.4037 mL

    * 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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