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  2. Cell Cycle/DNA Damage Apoptosis
  3. Nucleoside Antimetabolite/Analog Apoptosis
  4. Dacarbazine

Dacarbazine  (Synonyms: 達(dá)卡巴嗪; Imidazole Carboxamide)

目錄號(hào): HY-B0078 純度: 99.96%
COA 產(chǎn)品使用指南

Dacarbazine 是一種非特異性抗腫瘤 (antineoplastic) 烷基化劑。Dacarbazine 抑制 T 和 B 淋巴細(xì)胞反應(yīng)，IC50 分別為 50 和 10 μg/mL。Dacarbazine 可用于轉(zhuǎn)移性惡性黑色素瘤的研究

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Dacarbazine Chemical Structure

Dacarbazine Chemical Structure

CAS No. : 4342-03-4

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥660
In-stock
50 mg ￥280
In-stock
100 mg ￥460
In-stock
200 mg ￥600
In-stock
1 g ￥1000
In-stock
5 g   詢(xún)價(jià)  
10 g   詢(xún)價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of Dacarbazine:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma[1][2][3][4][5].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
> 100 μM
Compound: DTIC
Antiproliferative activity against human A375 cells after 48 hrs by SRB assay
Antiproliferative activity against human A375 cells after 48 hrs by SRB assay
[PMID: 20056548]
A-375 IC50
> 100 μM
Compound: DTIC, dacarbazine
Antiproliferative activity against human A375 cells after 48 hrs by SRB assay
Antiproliferative activity against human A375 cells after 48 hrs by SRB assay
[PMID: 18477505]
A-375 IC50
> 500 μM
Compound: dacarbazine
Cytotoxicity against human A375 cells after 48 hrs by MTT assay
Cytotoxicity against human A375 cells after 48 hrs by MTT assay
[PMID: 22560315]
A549 IC50
35 μg/mL
Compound: Dacarbazine
Cytotoxicity against Homo sapiens (human) A549 cells assessed as cell viability by MTT assay
Cytotoxicity against Homo sapiens (human) A549 cells assessed as cell viability by MTT assay
10.1007/s00044-007-9031-x
B16-F1 IC50
> 100 μM
Compound: DTIC
Antiproliferative activity against mouse B16-F1 cells after 48 hrs by SRB assay
Antiproliferative activity against mouse B16-F1 cells after 48 hrs by SRB assay
[PMID: 20056548]
B16-F1 IC50
> 100 μM
Compound: DTIC, dacarbazine
Antiproliferative activity against mouse B16-F1 cells after 48 hrs by SRB assay
Antiproliferative activity against mouse B16-F1 cells after 48 hrs by SRB assay
[PMID: 18477505]
Fibroblast IC50
> 100 μM
Compound: DTIC
Cytotoxicity against human fibroblasts after 48 hrs by SRB assay
Cytotoxicity against human fibroblasts after 48 hrs by SRB assay
[PMID: 20056548]
HeLa GI50
> 50 μM
Compound: DTIC
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay
[PMID: 24986661]
OVCAR-3 IC50
17.67 μM
Compound: Dacarbazine
Cytotoxicity against human OVCAR3 cells after 6 days by MTT assay
Cytotoxicity against human OVCAR3 cells after 6 days by MTT assay
[PMID: 21131205]
SK-MEL-2 IC50
120 μM
Compound: Dacarbazine
Cytotoxicity against human SK-MEL-2 cells after 6 days by MTT assay
Cytotoxicity against human SK-MEL-2 cells after 6 days by MTT assay
[PMID: 21131205]
UACC-62 IC50
11.83 μM
Compound: Dacarbazine
Cytotoxicity against human UACC62 cells after 6 days by MTT assay
Cytotoxicity against human UACC62 cells after 6 days by MTT assay
[PMID: 21131205]
WM164 IC50
> 100 μM
Compound: DTIC
Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay
Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay
[PMID: 20056548]
WM164 IC50
> 100 μM
Compound: DTIC
Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay
Antiproliferative activity against human WM164 cells after 48 hrs by SRB assay
[PMID: 17561392]
體外研究
(In Vitro)

Dacarbazine (6.25-500 μg/mL 48 h) 聯(lián)合熱療可誘導(dǎo) A375 和 MNT-1 黑色素瘤細(xì)胞的細(xì)胞毒性[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[5]

Cell Line: A375, MNT-1
Concentration: 6.25, 12.5, 25, 50, 100, 200, 400, 500 μg/mL
Incubation Time: 24, 48, 72 h
Result: Inhibited cell viability in a concentration-dependent manner.

Cell Cycle Analysis[5]

Cell Line: A375, MNT-1
Concentration: 5.5, 115 μg/mL
Incubation Time: 48 h
Result: Decreased (9.3%) the percentage of A375 cells at the S phase and increased the number of cells at G2/M.
Decreased MNT-1 cells at G0/G1, increasing in cells at both S and G2/M phases.
Clinical Trial
分子量

182.18

Formula

C6H10N6O
CAS 號(hào)
性狀

固體

顏色

White to yellow

中文名稱(chēng)

達(dá)卡巴嗪；氨烯咪胺；甲嗪咪唑胺；三嗪咪唑胺
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

0.1 M HCL 中的溶解度 : 20 mg/mL (109.78 mM; 超聲助溶 (<60°C))

DMSO 中的溶解度 : 5 mg/mL (27.45 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 5.4891 mL 27.4454 mL 54.8908 mL
5 mM 1.0978 mL 5.4891 mL 10.9782 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶。

  • 方案 一

    請(qǐng)依序添加每種溶劑： PBS

    Solubility: 2 mg/mL (10.98 mM); 澄清溶液; 超聲助溶 (<60°C)

  • 方案 二

    請(qǐng)依序添加每種溶劑： 50% PEG300    50% Saline

    Solubility: 5 mg/mL (27.45 mM); 懸濁液; 超聲助溶

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.96%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO / 0.1 M HCL 1 mM 5.4891 mL 27.4454 mL 54.8908 mL 137.2269 mL
5 mM 1.0978 mL 5.4891 mL 10.9782 mL 27.4454 mL
10 mM 0.5489 mL 2.7445 mL 5.4891 mL 13.7227 mL
15 mM 0.3659 mL 1.8297 mL 3.6594 mL 9.1485 mL
20 mM 0.2745 mL 1.3723 mL 2.7445 mL 6.8613 mL
25 mM 0.2196 mL 1.0978 mL 2.1956 mL 5.4891 mL
0.1 M HCL 30 mM 0.1830 mL 0.9148 mL 1.8297 mL 4.5742 mL
40 mM 0.1372 mL 0.6861 mL 1.3723 mL 3.4307 mL
50 mM 0.1098 mL 0.5489 mL 1.0978 mL 2.7445 mL
60 mM 0.0915 mL 0.4574 mL 0.9148 mL 2.2871 mL
80 mM 0.0686 mL 0.3431 mL 0.6861 mL 1.7153 mL
100 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.3723 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
Dacarbazine
目錄號(hào)：
HY-B0078
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