9 | 940867-25-4 | RP-56976-d9 | 多西他賽 d9 | Microtubule/Tubulin | Apoptosis | Endogenous Metabolite | Inhibitor | inhibitor | inhibit"/>

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  2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis Metabolic Enzyme/Protease
  3. Microtubule/Tubulin Apoptosis Endogenous Metabolite
  4. Docetaxel-d9

Docetaxel-d9 是 Docetaxel 的氘代物。Docetaxel (RP-56976) 是一種微管解聚 (microtubule?depolymerization) 抑制劑，其 IC50 值為 0.2 μM。Docetaxel 是紫杉醇的半合成類(lèi)似物，能減弱 bcl-2 和 bcl-xL 基因表達(dá)的影響。Docetaxel 阻滯 G2/M 細(xì)胞周期，導(dǎo)致細(xì)胞凋亡 (apoptosis)。Docetaxel 具有抗腫瘤活性。

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Docetaxel-d<sub>9</sub> Chemical Structure

Docetaxel-d9 Chemical Structure

CAS No. : 940867-25-4

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規(guī)格 價(jià)格 是否有貨
1 mg ￥8500
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Customer Review

Other Forms of Docetaxel-d9:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Docetaxel-d9 is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity[1][3].

體外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

816.93

Formula

C43H44D9NO14
CAS 號(hào)
非標(biāo)記 CAS
性狀

固體

顏色

White to off-white

中文名稱

多西他賽 d9
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Docetaxel-d9
目錄號(hào)：
HY-B0011S
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