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  2. Vitamin D Related/Nuclear Receptor Apoptosis
  3. VD/VDR Apoptosis
  4. Eldecalcitol

Eldecalcitol  (Synonyms: 艾地骨化醇; ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3)

目錄號(hào): HY-A0020 純度: 99.86%
COA 產(chǎn)品使用指南 技術(shù)支持

Eldecalcitol (ED-71) 是一種具有口服活性維生素 D3 類似物，可抑制骨吸收并增加骨密度。Eldecalcitol 具有抗腫瘤作用，抑制細(xì)胞增殖、遷移，并通過抑制 GPx-1 來誘導(dǎo)細(xì)胞凋亡 (apoptosis)。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Eldecalcitol Chemical Structure

Eldecalcitol Chemical Structure

CAS No. : 104121-92-8

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1 mg ￥1600
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Customer Review

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MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1[1][2][3][4].

體外研究
(In Vitro)

Eldecalcitol (0-50 nM；24 小時(shí)) 沒有細(xì)胞毒性，可 (0.5-50 nM；24 小時(shí)) 減少 LPS (5 μg/mL) 誘導(dǎo)的細(xì)胞死亡[2]。
Eldecalcitol (5 nM；24 h) 通過激活 Nrf2 及其效應(yīng)分子 HO-1[2]抑制 LPS 誘導(dǎo)的細(xì)胞焦亡。
Eldecalcitol (0.5-50 nM；24 h) 具有抗細(xì)胞焦亡能力，并以劑量依賴性方式降低 NLRP3、caspase-1 和 IL-1β 的表達(dá)[3]。
Eldecalcitol (0.04-40 nM；0-48 h) 抑制SCC-15 和 CAL-27 細(xì)胞的增殖和遷移[3]。
Eldecalcitol (0.4 nM；48 h) 使細(xì)胞周期停滯在 G0/G1 期，并通過抑制GPx-1 (谷胱甘肽過氧化物酶) 在胃癌細(xì)胞中的表達(dá)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Human gingival fibroblasts (HGFs)
Concentration: 0, 0.5, 5, and 50 nM
Incubation Time: 24 hours
Result: Decreased TLR4, NLRP3, caspase-1 p20, ASC, and GSDMD-N level in a dose-dependent manner compared with the group treated with LPS.
Reduced the release of IL-1β and IL-18 induced by LPS to normal levels.

Cell Proliferation Assay[3]

Cell Line: SCC-15 and CAL-27 cells
Concentration: 0, 0.04, 0.4, 4, and 40 nM
Incubation Time: 6, 8, 12, 24, 48 hours
Result: Inhibited the cell viability of the OSCC cells to reach 50% at 24 h with 0.4 nM.

Cell Proliferation Assay[3]

Cell Line: OSCC cells
Concentration: 0.4 nM
Incubation Time: 48 hours
Result: Increased the proportion of cells at the late phases of apoptosis from 7.1% to 16.1%.
Upregulated Bax and caspase-3, downregulated Bcl-2.
Significantly triggered apoptosis in SCC- 15 and CAL- 27 cells.
體內(nèi)研究
(In Vivo)

Eldecalcitol (0.5 μg/kg；口服；每周兩次，持續(xù) 4 周) 通過抑制 GPx-1 (谷胱甘肽過氧化物酶) 顯示出抗癌作用[3]。
Eldecalcitol (10，30，或 90 ng/kg；口服；每周 5 次，持續(xù) 12 周)，作為一種更有效的維生素 D3 類似物，可刺激局灶性骨形成 (微型模型) 并比骨化三醇更強(qiáng)烈地抑制骨吸收[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Xenograft tumor model in mice (male athymic nude BALB/c mice)[3]
Dosage: 0.5 μg/kg
Administration: Oral gavage; twice a week for 4 weeks
Result: Reduced the growth rate of tumors, and downregulated the expression levels of PCNA and MMP- 2 and upregulated the expression of Bax in the tumors.
Resulted in decrease of proliferation, the inhibition of migration, and the promotion of apoptosis.
Animal Model: Ovariectomized (OVX) rat model[4]
Dosage: 10, 30, or 90 ng/kg
Administration: Oral gavage; 5-times per week for 12 weeks
Result: Increased the lumbar and femoral BMD in a dose dependent manner. Stimulated focal bone formation that started without prior bone resorption, a process known as bone minimodeling.
Clinical Trial
分子量

490.72

Formula

C30H50O5
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

艾爾骨化醇；艾地骨化醇
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

Methanol 中的溶解度 : 8.33 mg/mL (16.98 mM; 超聲助溶)

DMSO 中的溶解度 : 3.33 mg/mL (6.79 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.0378 mL 10.1891 mL 20.3782 mL
5 mM 0.4076 mL 2.0378 mL 4.0756 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.94%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO / Methanol 1 mM 2.0378 mL 10.1891 mL 20.3782 mL 50.9455 mL
5 mM 0.4076 mL 2.0378 mL 4.0756 mL 10.1891 mL
Methanol 10 mM 0.2038 mL 1.0189 mL 2.0378 mL 5.0946 mL
15 mM 0.1359 mL 0.6793 mL 1.3585 mL 3.3964 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Eldecalcitol
目錄號(hào)：
HY-A0020
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