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  2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. (2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride

(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride 

目錄號(hào): HY-76104 純度: ≥98.0%
COA 產(chǎn)品使用指南

cis-4-Hydroxy-D-proline (hydrochloride) 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗體偶聯(lián)活性分子 (ADCs)。cis-4-Hydroxy-D-proline (hydrochloride) 也是一個(gè)基于烷基鏈 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

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(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride Chemical Structure

(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride Chemical Structure

CAS No. : 77449-94-6

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Other Forms of (2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target

Non-cleavable Linker

 

體外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

167.59

Formula

C5H10ClNO3
CAS 號(hào)
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride 相關(guān)分類

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
目錄號(hào)：
HY-76104
需求量：