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  2. Vitamin D Related/Nuclear Receptor
  3. VD/VDR
  4. Lexacalcitol

Lexacalcitol  (Synonyms: 來沙骨化醇; KH1060)

目錄號(hào): HY-32340 純度: 99.42%
COA 產(chǎn)品使用指南

Lexacalcitol (KH1060) 是一種維生素 D 類似物，是細(xì)胞生長和免疫反應(yīng)的有效調(diào)節(jié)劑。Lexacalcitol 可用于移植排斥反應(yīng)、銀屑病、癌癥和自身免疫性疾病的研究。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Lexacalcitol Chemical Structure

Lexacalcitol Chemical Structure

CAS No. : 131875-08-6

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥2560
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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases[1][2].

體外研究
(In Vitro)

Lexacalcitol inhibits cell proliferation by 50% at 10-12 M (14,000 times more active than la,25(OH)2D3) in human histiocytic lymphoma cell line U 937[1].
Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10-16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10-15 M[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female spontaneously diabetic NOD mice[2]
Dosage: 0.5 mg/kg/2 days
Administration: Intraperitoneal injection
Result: Single treatment with KH1060 or CyA did not result in statistically significant suppression of early graft failure, while the combination of KH1060 and CyA can prevent early graft failure and delay graft rejection of xenogeneic islets in spontaneously diabetic NOD mice.
分子量

460.69

Formula

C29H48O4
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

來沙骨化醇
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

-20°C, protect from light, stored under nitrogen

*該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 100 mg/mL (217.07 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.1707 mL 10.8533 mL 21.7066 mL
5 mM 0.4341 mL 2.1707 mL 4.3413 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1707 mL 10.8533 mL 21.7066 mL 54.2664 mL
5 mM 0.4341 mL 2.1707 mL 4.3413 mL 10.8533 mL
10 mM 0.2171 mL 1.0853 mL 2.1707 mL 5.4266 mL
15 mM 0.1447 mL 0.7236 mL 1.4471 mL 3.6178 mL
20 mM 0.1085 mL 0.5427 mL 1.0853 mL 2.7133 mL
25 mM 0.0868 mL 0.4341 mL 0.8683 mL 2.1707 mL
30 mM 0.0724 mL 0.3618 mL 0.7236 mL 1.8089 mL
40 mM 0.0543 mL 0.2713 mL 0.5427 mL 1.3567 mL
50 mM 0.0434 mL 0.2171 mL 0.4341 mL 1.0853 mL
60 mM 0.0362 mL 0.1809 mL 0.3618 mL 0.9044 mL
80 mM 0.0271 mL 0.1357 mL 0.2713 mL 0.6783 mL
100 mM 0.0217 mL 0.1085 mL 0.2171 mL 0.5427 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Lexacalcitol
目錄號(hào)：
HY-32340
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