成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

  1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. Methoxsalen

Methoxsalen  (Synonyms: 甲氧沙林; 8-Methoxypsoralen; Xanthotoxin; 8-MOP)

目錄號: HY-30151 純度: 99.98%
COA 產品使用指南

Methoxsalen (8-Methoxypsoralen) 是呋喃香豆素化合物,可用于補骨脂,用于研究牛皮癬,濕疹,白癜風和一些暴露在陽光下的皮膚淋巴瘤,是P450抑制劑。

MCE 的所有產品僅用作科學研究或藥證申報,我們不為任何個人用途提供產品和服務

Methoxsalen Chemical Structure

Methoxsalen Chemical Structure

CAS No. : 298-81-7

1.  客戶無需承擔相應的運輸費用。

2.  同一機構(單位)同一產品試用裝僅限申領一次,同一機構(單位)一年內

     可免費申領三個不同產品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ¥500
In-stock
500 mg ¥350
In-stock
1 g ¥420
In-stock
5 g   詢價  
10 g   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Methoxsalen:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-431 IC50
> 30 μM
Compound: 8-MOP
Antiproliferative activity against human A431 cells after 24 hrs by trypan blue dye assay
Antiproliferative activity against human A431 cells after 24 hrs by trypan blue dye assay
[PMID: 22537681]
A-431 IC50
2.48 μM
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against A 431 cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against A 431 cell line by irradiation in the presence of examined compound
[PMID: 8893844]
A-431 IC50
25 μM
Compound: 8-MOP
Antiproliferative activity against human A431 cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
Antiproliferative activity against human A431 cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
[PMID: 22537681]
AGS IC50
> 100 μM
Compound: Xanthotoxin
Anti-proliferative activity against human AGS cells after 48 hrs by MTT assay
Anti-proliferative activity against human AGS cells after 48 hrs by MTT assay
[PMID: 28947149]
HCT-116 IC50
> 100 μM
Compound: 6
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
[PMID: 23746477]
HeLa IC50
> 30 μM
Compound: 8-MOP
Antiproliferative activity against human HeLa cells after 24 hrs by trypan blue dye assay
Antiproliferative activity against human HeLa cells after 24 hrs by trypan blue dye assay
[PMID: 22537681]
HeLa IC50
10 μM
Compound: 8-MOP
Antiproliferative activity against human HeLa cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
Antiproliferative activity against human HeLa cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
[PMID: 22537681]
HeLa IC50
3.16 μM
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against HeLa cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against HeLa cell line by irradiation in the presence of examined compound
[PMID: 8893844]
HeLa IC50
7.6 μg/mL
Compound: Xanthotoxin
Antitumor activity against human HeLa cells after 72 hrs by MTS assay
Antitumor activity against human HeLa cells after 72 hrs by MTS assay
[PMID: 19217697]
HL-60 IC50
> 20 μM
Compound: 8-MOP
Cytotoxicity against human HL60 cells treated under dark condition after 24 hrs by trypan blue assay
Cytotoxicity against human HL60 cells treated under dark condition after 24 hrs by trypan blue assay
[PMID: 20615713]
HL-60 IC50
> 20 μM
Compound: 8-MOP
Cytotoxicity against human HL60 cells treated under dark condition after 72 hrs by trypan blue assay
Cytotoxicity against human HL60 cells treated under dark condition after 72 hrs by trypan blue assay
[PMID: 20615713]
HL-60 IC50
0.75 μM
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against HL 60 cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against HL 60 cell line by irradiation in the presence of examined compound
[PMID: 8893844]
HL-60 IC50
1.2 μM
Compound: 8-MOP
Photocytotoxicity against human HL-60 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HL-60 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HL-60 IC50
1.4 μM
Compound: 8-MOP
Photocytotoxicity against human HL-60 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HL-60 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HL-60 IC50
5.4 μM
Compound: 8-MOP
Cytotoxicity against human HL60 cells after 24 hrs by trypan blue assay in presence of 0.789 J cm-2 of UVA light
Cytotoxicity against human HL60 cells after 24 hrs by trypan blue assay in presence of 0.789 J cm-2 of UVA light
[PMID: 20615713]
HT-1080 IC50
1.5 μM
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 6.5 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 6.5 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
HT-1080 IC50
1.9 μM
Compound: 8-MOP
Photocytotoxicity against human HT1080 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HT1080 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HT-1080 IC50
2.1 μM
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 3.2 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 3.2 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
HT-1080 IC50
7.8 μM
Compound: 8-MOP
Photocytotoxicity against human HT1080 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HT1080 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HT-1080 IC50
7.8 μM
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 2.6 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 2.6 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
HT-29 IC50
> 100 μM
Compound: 6
Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
[PMID: 23746477]
Jurkat IC50
> 20 μM
Compound: 8MOP
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
[PMID: 19230658]
Jurkat IC50
1.2 μM
Compound: 8-MOP
Photocytotoxicity against human JURKAT cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human JURKAT cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
Jurkat IC50
1.2 μM
Compound: 8MOP
Phototoxicity against human Jurkat cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human Jurkat cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
K562 IC50
> 20 μM
Compound: 8MOP
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
[PMID: 19230658]
L02 IC50
> 100 μM
Compound: Xanthotoxin
Anti-proliferative activity against human L02 cells after 48 hrs by MTT assay
Anti-proliferative activity against human L02 cells after 48 hrs by MTT assay
[PMID: 28947149]
LoVo IC50
> 20 μM
Compound: 8MOP
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
[PMID: 19230658]
LoVo IC50
0.7 μM
Compound: 8-MOP
Photocytotoxicity against human LoVo cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
LoVo IC50
0.7 μM
Compound: 8MOP
Phototoxicity against human LoVo cells exposed to irradiation with 3.75 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human LoVo cells exposed to irradiation with 3.75 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
LoVo IC50
1.1 μM
Compound: 8-MOP
Photocytotoxicity against human LoVo cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
LoVo IC50
1.1 μM
Compound: 8MOP
Phototoxicity against human LoVo cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human LoVo cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
MES-SA/Dx5 IC50
3.1 μM
Compound: 6
Cytotoxicity against human MES-SA/Dx5 cells after 96 hrs by MTT assay
Cytotoxicity against human MES-SA/Dx5 cells after 96 hrs by MTT assay
[PMID: 23746477]
NCTC-2544 IC50
> 20 μM
Compound: 8MOP
Cytotoxicity against human NCTC-2544 cells after 72 hrs by MTT assay
Cytotoxicity against human NCTC-2544 cells after 72 hrs by MTT assay
[PMID: 19230658]
NCTC-2544 IC50
0.9 μM
Compound: 8-MOP
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
NCTC-2544 IC50
5.5 μM
Compound: 8-MOP
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
NCTC-2544 IC50
5.5 μM
Compound: 8MOP
Phototoxicity against human NCTC-2544 cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human NCTC-2544 cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
PAM212 IC50
> 100 μM
Compound: 2; 8-MOP
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 30 mins under dark condition measured after 5 days by coulter counting method
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 30 mins under dark condition measured after 5 days by coulter counting method
[PMID: 30638875]
PAM212 IC50
> 100 μM
Compound: 2; 8-MOP
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 5 days under dark condition by coulter counting method
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 5 days under dark condition by coulter counting method
[PMID: 30638875]
PAM212 IC50
0.1 μM
Compound: 2; 8-MOP
Phototoxicity against mouse PAM212 cells assessed as cell growth inhibition preincubated for 30 mins followed by 1.28 J/cm2 UV light exposure and measured after 5 days by coulter counting method
Phototoxicity against mouse PAM212 cells assessed as cell growth inhibition preincubated for 30 mins followed by 1.28 J/cm2 UV light exposure and measured after 5 days by coulter counting method
[PMID: 30638875]
PANC-1 IC50
83.3 μM
Compound: 6
Cytotoxicity against human PANC1 cells after 96 hrs by MTT assay
Cytotoxicity against human PANC1 cells after 96 hrs by MTT assay
[PMID: 23746477]
體內研究
(In Vivo)

Methoxsalen(15mg/kg,腹腔注射,單劑量)增加尼古丁的 Cmax,延長血漿尼古丁半衰期(增加四倍),降低其清除率(減少六倍),并增加其 AUC[ 1]。
Methoxsalen(15mg/kg,腹腔注射,單劑量)可增強口服尼古丁的藥理作用(體溫和鎮(zhèn)痛)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male adult ICR mice[1]
Dosage: 15 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose
Result: Increased nicotine plasma levels were still above 10ng/ml at 6hr.
Induced nicotine’s antinociceptive and hypothermic lasted close to 6 and 24 hr.
Clinical Trial
分子量

216.19

Formula

C12H8O4

CAS 號
性狀

固體

顏色

White to light yellow

中文名稱

花椒毒素;8-甲氧基補骨酯;甲氧基補骨脂素;8-甲氧基補骨脂素;甲氧沙林;8-甲氧補骨脂素;甲氧補骨脂素;8-甲氧補骨脂

結構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗: 

DMSO 中的溶解度 : 50 mg/mL (231.28 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對產品的溶解度有顯著影響,請使用新開封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 4.6256 mL 23.1278 mL 46.2556 mL
5 mM 0.9251 mL 4.6256 mL 9.2511 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復凍融造成的產品失效。
儲備液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C儲存時,請在2年內使用, -20°C儲存時,請在1年內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗:

請根據(jù)您的 實驗動物和給藥方式 選擇適當?shù)娜芙夥桨浮?

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液,再依次添加助溶劑:
——為保證實驗結果的可靠性,澄清的儲備液可以根據(jù)儲存條件,適當保存;體內實驗的工作液,建議您現(xiàn)用現(xiàn)配,當天使用;
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比;如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象,可以通過加熱和/或超聲的方式助溶

  • 方案 一

    請依序添加每種溶劑: 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.56 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL(飽和度未知)的澄清溶液。

    1 mL 工作液為例,取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中,混合均勻;再向上述體系中加入 50 μL Tween-80,混合均勻;然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制:將 0.9 g 氯化鈉,溶解于 ddH?O 并定容至 100 mL,可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請依序添加每種溶劑: 10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (11.56 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL(飽和度未知)的澄清溶液,此方案實驗周期在半個月以上的動物實驗酌情使用。

    1 mL 工作液為例,取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL玉米油中,混合均勻。

動物溶解方案計算器
請輸入動物實驗的基本信息:

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

由于實驗過程有損耗,建議您多配一只動物的量
請輸入您的動物體內配方組成:
%
DMSO +
+
%
Tween-80 +
%
Saline
如果您的動物是免疫缺陷鼠或者體弱鼠,建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
方案所需 助溶劑 包括:DMSO, ,均可在 MCE 網(wǎng)站選購。 ,Tween 80,均可在 MCE 網(wǎng)站選購。
計算結果
工作液所需濃度 : mg/mL
儲備液配制方法 : mg 藥物溶于 μL  DMSO(母液濃度為 mg/mL)。
您所需的儲備液濃度超過該產品的實測溶解度,以下方案僅供參考,如有需要,請與 MCE 中國技術支持聯(lián)系。
動物實驗體內工作液的配制方法 : 取 μL DMSO 儲備液,加入 μL 。 μL ,混合均勻至澄清,再加 μL Tween 80,混合均勻至澄清,再加 μL 生理鹽水
連續(xù)給藥周期超過半月以上,請謹慎選擇該方案。
請確保第一步儲備液溶解至澄清狀態(tài),從左到右依次添加助溶劑。您可采用超聲加熱 (超聲清洗儀,建議頻次 20-40 kHz),渦旋吹打等方式輔助溶解。
純度 & 產品資料

純度: 99.98%

參考文獻

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復凍融造成的產品失效。
儲備液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C儲存時,請在2年內使用, -20°C儲存時,請在1年內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6256 mL 23.1278 mL 46.2556 mL 115.6390 mL
5 mM 0.9251 mL 4.6256 mL 9.2511 mL 23.1278 mL
10 mM 0.4626 mL 2.3128 mL 4.6256 mL 11.5639 mL
15 mM 0.3084 mL 1.5419 mL 3.0837 mL 7.7093 mL
20 mM 0.2313 mL 1.1564 mL 2.3128 mL 5.7820 mL
25 mM 0.1850 mL 0.9251 mL 1.8502 mL 4.6256 mL
30 mM 0.1542 mL 0.7709 mL 1.5419 mL 3.8546 mL
40 mM 0.1156 mL 0.5782 mL 1.1564 mL 2.8910 mL
50 mM 0.0925 mL 0.4626 mL 0.9251 mL 2.3128 mL
60 mM 0.0771 mL 0.3855 mL 0.7709 mL 1.9273 mL
80 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4455 mL
100 mM 0.0463 mL 0.2313 mL 0.4626 mL 1.1564 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的產品:

Your information is safe with us. * Required Fields.

   產品名稱:

 

* 需求量:

* 客戶姓名:

 

* Email:

* 電話:

 

* 公司或機構名稱:

   留言給我們:

Bulk Inquiry

Inquiry Information

產品名稱:
Methoxsalen
目錄號:
HY-30151
需求量: