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  2. Anti-infection
  3. Parasite
  4. ICA

ICA  (Synonyms: N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine)

目錄號: HY-22044 純度: 99.92%
COA 產品使用指南 技術支持

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) 是SK通道 (SK channel) 抑制劑。ICA有抗利什曼原蟲活性，IC50 值為2.1 μM。

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ICA Chemical Structure

ICA Chemical Structure

CAS No. : 3374-88-7

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1488
In-stock
5 mg ￥3600
In-stock
10 mg ￥5400
In-stock
25 mg 現(xiàn)貨 詢價
50 mg 現(xiàn)貨 詢價
100 mg 現(xiàn)貨 詢價
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Customer Review

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 μM.

IC50 & Target

IC50: 2.1 μM (Antileishmanial)[1]
細胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
0.025 μM
Compound: 1
Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assay
Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assay
[PMID: 18774291]
HEK293 IC50
0.043 μM
Compound: 1
Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assay
Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assay
[PMID: 18774291]
HEK293 IC50
0.123 μM
Compound: 1
Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assay
Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assay
[PMID: 18774291]
HEK293 IC50
0.29 μM
Compound: 1
Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay
Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay
[PMID: 18774291]
HEK293 IC50
0.543 μM
Compound: 1
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay
[PMID: 18774291]
J774.A1 IC50
2.1 μM
Compound: 25
Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 expressing luciferase reporter gene infected in mouse J-774A1 cells assessed as inhibition of amastigote stage formation incubated for 72 hrs by luminometry
Antileishmanial activity against Leishmania donovani MHOM/IN/80/Dd8 expressing luciferase reporter gene infected in mouse J-774A1 cells assessed as inhibition of amastigote stage formation incubated for 72 hrs by luminometry
[PMID: 26318065]
KB CC50
75.6 μM
Compound: 25
Cytotoxicity in human KB cells assessed as cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in human KB cells assessed as cell viability incubated for 72 hrs by MTT assay
[PMID: 26318065]
體外研究
(In Vitro)

The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

254.31

Formula

C13H10N4S
CAS 號
性狀

固體

顏色

Light brown to brown

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據
細胞實驗： 

DMSO 中的溶解度 : ≥ 49.5 mg/mL (194.64 mM; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 3.9322 mL 19.6610 mL 39.3221 mL
5 mM 0.7864 mL 3.9322 mL 7.8644 mL
查看完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內使用， -20°C儲存時，請在1年內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料

純度: 99.92%

參考文獻

完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內使用， -20°C儲存時，請在1年內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9322 mL 19.6610 mL 39.3221 mL 98.3052 mL
5 mM 0.7864 mL 3.9322 mL 7.8644 mL 19.6610 mL
10 mM 0.3932 mL 1.9661 mL 3.9322 mL 9.8305 mL
15 mM 0.2621 mL 1.3107 mL 2.6215 mL 6.5537 mL
20 mM 0.1966 mL 0.9831 mL 1.9661 mL 4.9153 mL
25 mM 0.1573 mL 0.7864 mL 1.5729 mL 3.9322 mL
30 mM 0.1311 mL 0.6554 mL 1.3107 mL 3.2768 mL
40 mM 0.0983 mL 0.4915 mL 0.9831 mL 2.4576 mL
50 mM 0.0786 mL 0.3932 mL 0.7864 mL 1.9661 mL
60 mM 0.0655 mL 0.3277 mL 0.6554 mL 1.6384 mL
80 mM 0.0492 mL 0.2458 mL 0.4915 mL 1.2288 mL
100 mM 0.0393 mL 0.1966 mL 0.3932 mL 0.9831 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
ICA
目錄號：
HY-22044
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