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  2. Anti-infection Apoptosis
  3. Bacterial HIV Apoptosis
  4. Aeroplysinin 1

Aeroplysinin 1  (Synonyms: (+)-Aeroplysinin-1)

目錄號(hào): HY-19827 純度: 95.0%
COA 產(chǎn)品使用指南

Aeroplysinin 1 ((+)-Aeroplysinin-1)，從海洋海綿中分離出的次生代謝產(chǎn)物，對(duì)革蘭氏陽性細(xì)菌 (bacteria) 顯示出有效的抗生素作用，并具有針對(duì) HIV-1 的抗病毒活性 (IC50=14.6 μM)。Aeroplysinin 1 具有抗炎，抗血管生成和抗腫瘤活性。Aeroplysinin 1誘導(dǎo)內(nèi)皮細(xì)胞凋亡 (apoptosis)。

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Aeroplysinin 1 Chemical Structure

Aeroplysinin 1 Chemical Structure

CAS No. : 28656-91-9

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規(guī)格 價(jià)格 是否有貨 數(shù)量
100 μg ￥5800
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查看 HIV 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells[1][2].

IC50 & Target[1]

Bacterial

 

HIV-1

14.6 μM (IC50)

Apoptosis

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa S3 IC50
18.8 μM
Compound: 1, aeroplysinin-1
Cytotoxicity against human HeLaS3 cells after 2 hrs by MTT assay
Cytotoxicity against human HeLaS3 cells after 2 hrs by MTT assay
[PMID: 8786366]
HeLa S3 IC50
2 μM
Compound: 1, aeroplysinin-1
Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 4 days to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 4 days to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
[PMID: 8786366]
HeLa S3 IC50
2.8 μM
Compound: 1, aeroplysinin-1
Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 4 days by MTT assay
[PMID: 8786366]
HeLa S3 IC50
27.5 μM
Compound: 1, aeroplysinin-1
Cytotoxicity against human HeLaS3 cells after 2 weeks by clonogenic assay
Cytotoxicity against human HeLaS3 cells after 2 weeks by clonogenic assay
[PMID: 8786366]
HeLa S3 IC50
3.5 μM
Compound: 1, aeroplysinin-1
Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 2 hrs to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
Dose enhancement factor, ratio of IC50 for human HeLaS3 cells after 2 hrs to IC50 for buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
[PMID: 8786366]
HeLa S3 IC50
5.4 μM
Compound: 1, aeroplysinin-1
Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
Cytotoxicity against buthionine sulfoximine-pretreated human HeLaS3 cells after 2 hrs by MTT assay
[PMID: 8786366]
HeLa S3 IC50
5.6 μM
Compound: 1, aeroplysinin-1
Cytotoxicity against human HeLaS3 cells after 4 days by MTT assay
Cytotoxicity against human HeLaS3 cells after 4 days by MTT assay
[PMID: 8786366]
體外研究
(In Vitro)

Aeroplysinin 1 shows anti-proliferative effect against tumor cells (HT-1080, HTC-116, HeLa, THP-1, NOMO-1 and HL-60 cells), with IC50s ranging from 2.3 to 17 μM[1].
Aeroplysinin-1 also exhibits an antiviral activity toward HIV-1 caused by inhibition of its reverse transcriptase activity[1].
Aeroplysinin 1 inhibits P. phosphoreum, C. wailesii, P. minimum and HIV with IC50s of 3.5, 5.6, 7.0 and 14.6 μM[1].
Aeroplysinin 1 inhibits human endothelial cells (EVLC-2, HMEC, RF-24, and HUVEC cells), with IC50s ranging from 2.6 to 4.7 μM[2].
(+)-Aeroplysinin-1 (0.25-0.5 μM) blocks the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibits the ligand-induced endocytosis of the EGF receptor in vitro[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

338.98

Formula

C9H9Br2NO3
CAS 號(hào)
性狀

固體

顏色

White to off-white

結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 3.39 mg/mL (10.00 mM; 超聲加熱助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.9500 mL 14.7501 mL 29.5003 mL
5 mM 0.5900 mL 2.9500 mL 5.9001 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 95.0%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9500 mL 14.7501 mL 29.5003 mL 73.7507 mL
5 mM 0.5900 mL 2.9500 mL 5.9001 mL 14.7501 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Aeroplysinin 1
目錄號(hào)：
HY-19827
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