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  2. Vitamin D Related/Nuclear Receptor
  3. Nuclear Hormone Receptor 4A/NR4A
  4. C-DIM12

C-DIM12  (Synonyms: DIM-C-pPhCl)

目錄號(hào): HY-19808 純度: 98.32%
COA 產(chǎn)品使用指南

C-DIM12 是一種有效，具有口服活性的 Nurr1 拮抗劑。C-DIM12 抑制腫瘤生長(zhǎng)和自噬，誘導(dǎo)細(xì)胞凋亡（apoptosis）。C-DIM12 具有抗炎和神經(jīng)保護(hù)作用，可用于癌癥和神經(jīng)系統(tǒng)疾病的研究。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

C-DIM12 Chemical Structure

C-DIM12 Chemical Structure

CAS No. : 178946-89-9

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規(guī)格 價(jià)格 是否有貨 數(shù)量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥495
In-stock
5 mg ￥450
In-stock
10 mg ￥720
In-stock
25 mg ￥1530
In-stock
50 mg ￥2430
In-stock
100 mg ￥3870
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

查看 Nuclear Hormone Receptor 4A/NR4A 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

C-DIM12 is a potent, orally active Nurr1 antagonist. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study[1][2][3].

IC50 & Target

Nurr1/NR4A2

 

體外研究
(In Vitro)

C-DIM12 (15 μM, 3-5 天) 通過(guò)抑制細(xì)胞自噬降低 MiaPaCa2 細(xì)胞的增殖和存活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

C-DIM12 (每次 25 mg/kg, 14 天) 改善帕金森小鼠的神經(jīng)膠質(zhì)反應(yīng)性[2]。
C-DIM12 (50-100 mg/kg, 每次 3 次)可減輕小鼠腦出血后腦炎癥，促進(jìn)功能恢復(fù)[3]。
C-DIM12 (30 mg/kg, 腹腔注射, 30 天) 抑制 NURR1-KO 細(xì)胞原位異種移植裸鼠的腫瘤生長(zhǎng)和自噬現(xiàn)象，促進(jìn)細(xì)胞凋亡[1]。
在C57BL/6雄性小鼠中的藥代動(dòng)力學(xué)分析[1]

Route Organ Dose (mg/kg) Area under Curve (ng/mL*min) t1/2 (min) Cmax (ng/mL)
i.g. Plasma 25 539,220 249 1120
i.g. Brain 25 2,273,711 265 3622

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MPTP-induced C57BL/6 male Parkinsonism mice [2]
Dosage: 25 mg/kg/day, 14day
Administration: Intragastric gavage (i.g.)
Result: Protected against the loss of DA neurons in the substantia nigra pars compacta and DA terminals in the striatum, maintained a ramified phenotype in microglia, and suppressed activation of astrocytes.
Animal Model: The ICR mice model of intracerebral hemorrhage induced by collagenase type VII[3]
Dosage: 50 and 100mg/kg/day at a 24-h interval, three times
Administration: Orally administration
Result: Improved the recovery of neurological function and prevented neuron loss in the hematoma, while suppressed activation of microglia/macrophages and expression of inflammatory mediators interleukin-6 and CC chemokine ligand 2.
Preserved axonal structures in the internal capsule and axonal transport function.
Decreased of iNOS mRNA expression.
Animal Model: MiaPaCa2 cells (Ctrl and NURR1-KO) orthotopic xenograft tumor models[1]
Dosage: 30 mg/kg, 30 day
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth and ATG7 and ATG12 mRNA levels, and induced apoptosis.
分子量

356.85

Formula

C23H17ClN2
CAS 號(hào)
性狀

固體

顏色

Light yellow to brown

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : ≥ 100 mg/mL (280.23 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.8023 mL 14.0115 mL 28.0230 mL
5 mM 0.5605 mL 2.8023 mL 5.6046 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8023 mL 14.0115 mL 28.0230 mL 70.0574 mL
5 mM 0.5605 mL 2.8023 mL 5.6046 mL 14.0115 mL
10 mM 0.2802 mL 1.4011 mL 2.8023 mL 7.0057 mL
15 mM 0.1868 mL 0.9341 mL 1.8682 mL 4.6705 mL
20 mM 0.1401 mL 0.7006 mL 1.4011 mL 3.5029 mL
25 mM 0.1121 mL 0.5605 mL 1.1209 mL 2.8023 mL
30 mM 0.0934 mL 0.4670 mL 0.9341 mL 2.3352 mL
40 mM 0.0701 mL 0.3503 mL 0.7006 mL 1.7514 mL
50 mM 0.0560 mL 0.2802 mL 0.5605 mL 1.4011 mL
60 mM 0.0467 mL 0.2335 mL 0.4670 mL 1.1676 mL
80 mM 0.0350 mL 0.1751 mL 0.3503 mL 0.8757 mL
100 mM 0.0280 mL 0.1401 mL 0.2802 mL 0.7006 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
C-DIM12
目錄號(hào)：
HY-19808
需求量：