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  2. PI3K/Akt/mTOR Autophagy NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. PI3K Autophagy Mitophagy Reactive Oxygen Species Apoptosis
  4. Quercetin

Quercetin 是一種天然黃酮類化合物，可激活或抑制許多蛋白質(zhì)的活性。Quercetin 可激活 SIRT1，也可抑制 PI3K，抑制 PI3Kγ，PI3Kδ，PI3Kβ 的 IC50 分別為 2.4 μM, 3.0 μM, 5.4 μM。

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Quercetin Chemical Structure

Quercetin Chemical Structure

CAS No. : 117-39-5

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10 mM * 1 mL in DMSO ￥500
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Customer Review

Other Forms of Quercetin:

MCE 顧客使用本產(chǎn)品發(fā)表的 85 篇科研文獻(xiàn)

WB

    Quercetin purchased from MCE. Usage Cited in: Life Sci. 2020 Sep 15;257:118116.  [Abstract]

    NRK-52E cells are treated with Quercetin (Quer, 20 μM) for 2 h prior to incubation with AngII (100 nM) for another 72 h. The expression of p21 and p16ink4a are detected using Western blotting, and quantitative analyses are performed.

    • 生物活性

    • 實(shí)驗(yàn)參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

    IC50 & Target[1]

    PI3Kδ

    2.4 μM (IC50)

    PI3Kγ

    3 μM (IC50)

    PI3Kβ

    5.4 μM (IC50)

    Autophagy

     

    Mitophagy

     

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    2008 IC50
    21.18 μM
    Compound: 1, Que
    Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 25906385]
    A2780 GI50
    19.7 μM
    Compound: Quercetin
    Growth inhibition of human A2780 cells incubated for 72 hrs by trypan blue assay
    Growth inhibition of human A2780 cells incubated for 72 hrs by trypan blue assay
    		[PMID: 32435372]
    A-375 IC50
    25.13 μM
    Compound: 1, Que
    Cytotoxicity against human A375 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human A375 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 25906385]
    A-431 IC50
    1.8 μg/mL
    Compound: quercetin
    Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting
    Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting
    		[PMID: 1666120]
    A-431 IC50
    23.04 μM
    Compound: 1, Que
    Cytotoxicity against human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 25906385]
    A-431 IC50
    34.37 μM
    Compound: 1, Que
    Cytotoxicity against cisplatin-resistant human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against cisplatin-resistant human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 25906385]
    A549 IC50
    > 10 μg/mL
    Compound: Compound 4
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    		[PMID: 25862199]
    A549 IC50
    > 10 μM
    Compound: 10
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    Cytotoxicity against human A549 cells after 48 hrs by SRB assay
    		[PMID: 28165740]
    A549 IC50
    > 20 mg/mL
    Compound: 18
    Cytotoxicity against human A549 cells after 3 days by SRB assay
    Cytotoxicity against human A549 cells after 3 days by SRB assay
    		[PMID: 15568778]
    A549 IC50
    13 μM
    Compound: Quer
    Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    A549 IC50
    6.2 μM
    Compound: 1
    Anticancer activity against human A549 cells by HTS assay
    Anticancer activity against human A549 cells by HTS assay
    		[PMID: 25139569]
    B16-4A5 IC50
    15 μM
    Compound: 7
    Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs by microplate reader analysis
    Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs by microplate reader analysis
    		[PMID: 25987378]
    B16-4A5 IC50
    15 μM
    Compound: 17
    Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs
    Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs
    		[PMID: 20189399]
    BALB/3T3 IC50
    217 μM
    Compound: 5
    Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay
    Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay
    		[PMID: 10096863]
    BT-549 IC50
    > 10 μM
    Compound: 10
    Cytotoxicity against human BT549 cells after 48 hrs by SRB assay
    Cytotoxicity against human BT549 cells after 48 hrs by SRB assay
    		[PMID: 28165740]
    BV-2 IC50
    10 μM
    Compound: Quercetin
    Antiinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production by Griess assay
    Antiinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production by Griess assay
    		[PMID: 24707938]
    BV-2 EC50
    10.5 μM
    Compound: Quercetin
    Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse BV-2 cells incubated for 24 hrs by Griess reagent based assay
    		[PMID: 34315042]
    BV-2 EC50
    11 μM
    Compound: quercetin
    Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated NO production after 24 hrs by Griess assay
    Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated NO production after 24 hrs by Griess assay
    		[PMID: 26473791]
    BV-2 IC50
    15.13 μM
    Compound: Quercetin
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs measured after 15 mins by Griess assay
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs measured after 15 mins by Griess assay
    		[PMID: 27335254]
    BV-2 IC50
    16.3 μM
    Compound: Quercetin
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess reagent based spectrophotometric analysis
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess reagent based spectrophotometric analysis
    		[PMID: 29122483]
    BV-2 IC50
    17.4 μM
    Compound: quercetin
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess assay
    		[PMID: 26327273]
    BV-2 IC50
    19.11 μM
    Compound: 10
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay
    		[PMID: 28165740]
    BV-2 IC50
    2.4 μM
    Compound: Quercetin
    Antineuroinflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs by Griess reagent based assay
    Antineuroinflammatory activity in mouse BV-2 cells assessed as inhibition of LPS-induced NO production measured after 24 hrs by Griess reagent based assay
    		[PMID: 31244147]
    BV-2 IC50
    2.4 μM
    Compound: Quercetin
    Inhibition of LPS-induced nitric oxide production in mouse BV2 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced nitric oxide production in mouse BV2 cells after 24 hrs by Griess assay
    		[PMID: 30132670]
    BV-2 IC50
    2.45 μM
    Compound: Quercetin
    Antineuroinflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay
    Antineuroinflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay
    		[PMID: 34978437]
    BV-2 IC50
    39.46 μM
    Compound: 1
    Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction
    Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction
    		[PMID: 27623545]
    BV-2 IC50
    4.3 μM
    Compound: Quercetin
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 30119995]
    BV-2 IC50
    4.3 μM
    Compound: Quercetin
    Inhibition of LPS-stimulated NO production in human BV2 cells after 24 hrs by Griess assay
    Inhibition of LPS-stimulated NO production in human BV2 cells after 24 hrs by Griess assay
    		[PMID: 25127164]
    BV-2 IC50
    6.5 μM
    Compound: Quercetin
    Inhibition of NO production in LPS-induced mouse BV-2 cells incubated for 24 hrs by Griess reagent based microplate reader analysis
    Inhibition of NO production in LPS-induced mouse BV-2 cells incubated for 24 hrs by Griess reagent based microplate reader analysis
    		[PMID: 36579935]
    BV-2 IC50
    7.2 μM
    Compound: Quercetin
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay
    Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay
    		[PMID: 29303577]
    BV-2 IC50
    8.7 μM
    Compound: Quercetin
    Inhibition of LPS-induced nitric oxide production in human BV2 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced nitric oxide production in human BV2 cells after 24 hrs by Griess assay
    		[PMID: 26696523]
    BV-2 EC50
    9.56 μM
    Compound: Qc
    Inhibition of LPS induced NO production in mouse BV-2 cells by Griess reagent based analysis
    Inhibition of LPS induced NO production in mouse BV-2 cells by Griess reagent based analysis
    		[PMID: 34875520]
    BXPC-3 IC50
    16 μM
    Compound: Quer
    Cytotoxicity against human BxPC3 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human BxPC3 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    BXPC-3 IC50
    24.12 μM
    Compound: 1, Que
    Cytotoxicity against human BxPC3 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human BxPC3 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 25906385]
    C13 IC50
    37.62 μM
    Compound: 1, Que
    Cytotoxicity against human C13 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human C13 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 25906385]
    C2C12 IC50
    30.79 μg/mL
    Compound: 3
    Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay
    		[PMID: 33412152]
    C6 IC50
    18.38 μM
    Compound: 51
    Inhibition of cell proliferation of rat C6 cells assessed as cell viability after 72 hrs by sulforhodamine B assay
    Inhibition of cell proliferation of rat C6 cells assessed as cell viability after 72 hrs by sulforhodamine B assay
    		[PMID: 25442304]
    C8166 CC50
    104.9 μg/mL
    Compound: 1
    Cytotoxicity against human C8166 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    Cytotoxicity against human C8166 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
    		[PMID: 24794743]
    C8166 EC50
    2.05 μg/mL
    Compound: 1
    Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis
    Antiviral activity against HIV-1 3B infected in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity by measuring syncytial cell number after 3 days by inverted microscopic analysis
    		[PMID: 24794743]
    Calu-1 IC50
    23.58 μM
    Compound: 1
    Anticancer activity against human Calu1 cells by HTS assay
    Anticancer activity against human Calu1 cells by HTS assay
    		[PMID: 25139569]
    CCRF-CEM IC50
    > 10 μg/mL
    Compound: 8
    Cytotoxicity against human CEM cells after 3 days by MTT assay
    Cytotoxicity against human CEM cells after 3 days by MTT assay
    		[PMID: 11421746]
    COLO 201 IC50
    19 μM
    Compound: Quer
    Cytotoxicity against human COLO201 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human COLO201 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    CWR22R IC50
    15.5 μM
    Compound: 16
    Antiproliferative activity against human 22Rv1 cells incubated up to 144 hrs by Coulter particle count and size analyzer
    Antiproliferative activity against human 22Rv1 cells incubated up to 144 hrs by Coulter particle count and size analyzer
    		[PMID: 22789812]
    DU-145 EC50
    > 100 μM
    Compound: Quercetin
    Antiproliferative activity against human DU145 cells after 24 hrs by MTT assay
    Antiproliferative activity against human DU145 cells after 24 hrs by MTT assay
    		[PMID: 21090565]
    DU-145 IC50
    > 100 μM
    Compound: Quercetin
    Antiproliferative activity against human DU145 cells after 3 days by WST-1 assay
    Antiproliferative activity against human DU145 cells after 3 days by WST-1 assay
    		[PMID: 30165345]
    DU-145 IC50
    > 100 μM
    Compound: 1
    Antiproliferative activity against human DU145 cells after 3 days by WST-1 assay
    Antiproliferative activity against human DU145 cells after 3 days by WST-1 assay
    		[PMID: 28760528]
    DU-145 IC50
    > 100 μM
    Compound: Quercetin
    Cytotoxicity against human androgen-independent DU145 cells assessed as inhibition of cell viability after 3 days by WST-1 cell proliferation assay
    Cytotoxicity against human androgen-independent DU145 cells assessed as inhibition of cell viability after 3 days by WST-1 cell proliferation assay
    		[PMID: 26341135]
    H9 EC50
    132 μM
    Compound: 4
    Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay
    Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay
    		[PMID: 8158164]
    H9 IC50
    132 μM
    Compound: 4
    Cytotoxicity against human H9 cells after 3 days
    Cytotoxicity against human H9 cells after 3 days
    		[PMID: 8158164]
    HCT-116 EC50
    > 100 μM
    Compound: Quercetin
    Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay
    		[PMID: 21090565]
    HCT-116 IC50
    23 μM
    Compound: 2
    Growth inhibition of human HCT116 cells overexpressing PI3Kalpha after 48 hrs by MTT assay
    Growth inhibition of human HCT116 cells overexpressing PI3Kalpha after 48 hrs by MTT assay
    		[PMID: 22212721]
    HCT-116 IC50
    43.87 μM
    Compound: Quercetin
    Cytotoxicity against human HCT-116 cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 33221062]
    HCT-116 IC50
    5.7 μM
    Compound: 2
    Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay
    Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay
    		[PMID: 22212721]
    HCT-116 IC50
    6.7 μM
    Compound: 2
    Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
    Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
    		[PMID: 22212721]
    HCT-15 IC50
    16.35 μM
    Compound: 1, Que
    Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human HCT15 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 25906385]
    HEK293 IC50
    0.68 μM
    Compound: 7a
    Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay
    Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay
    		[PMID: 20731357]
    HEK293 IC50
    54.65 μM
    Compound: 1, Que
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 25906385]
    HEK293 IC50
    6.5 μM
    Compound: 22
    Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in gadolinium-induced calcium entry after 30 mins by fluo-4 dye based fluorescence assay
    Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in gadolinium-induced calcium entry after 30 mins by fluo-4 dye based fluorescence assay
    		[PMID: 30943030]
    HeLa IC50
    ≥ 10 μM
    Compound: quercetin
    Cytotoxicity against human HeLa cells by MTT assay
    Cytotoxicity against human HeLa cells by MTT assay
    		[PMID: 19278239]
    HeLa GI50
    17.7 μM
    Compound: Quercetin
    Growth inhibition of human HeLa cells incubated for 72 hrs by trypan blue assay
    Growth inhibition of human HeLa cells incubated for 72 hrs by trypan blue assay
    		[PMID: 32435372]
    HeLa IC50
    22.5 μM
    Compound: Quercetin
    Cytotoxicity against human HeLa cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay
    		[PMID: 33221062]
    HeLa IC50
    3.56 μM
    Compound: 1
    Anticancer activity against human HeLa cells by HTS assay
    Anticancer activity against human HeLa cells by HTS assay
    		[PMID: 25139569]
    HeLa IC50
    4 μM
    Compound: 30
    Cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay
    		[PMID: 33355454]
    HeLa IC50
    8.26 μg/mL
    Compound: Compound 4
    Cytotoxicity against human HeLa cells by MTT assay
    Cytotoxicity against human HeLa cells by MTT assay
    		[PMID: 25862199]
    HepG2 IC50
    > 10 μM
    Compound: quercetin
    Cytotoxicity against human HepG2 cells by MTT assay
    Cytotoxicity against human HepG2 cells by MTT assay
    		[PMID: 19583252]
    HepG2 IC50
    11 μM
    Compound: Quercetin
    Antioxidant activity in human HepG2 cells assessed as inhibition of ABAP-induced intracellular peroxyl radical scavenging activity by measuring ROS production measured every 5 mins for 1 hr by absorbance assay
    Antioxidant activity in human HepG2 cells assessed as inhibition of ABAP-induced intracellular peroxyl radical scavenging activity by measuring ROS production measured every 5 mins for 1 hr by absorbance assay
    		[PMID: 24471493]
    HepG2 IC50
    12 μM
    Compound: Quercetin
    Antioxidant activity in human HepG2 cells assessed as inhibition of ABAP-induced peroxyl radical generation incubated for 60 mins measured for 60 mins by DCFH-DA probe based fluorescence assay
    Antioxidant activity in human HepG2 cells assessed as inhibition of ABAP-induced peroxyl radical generation incubated for 60 mins measured for 60 mins by DCFH-DA probe based fluorescence assay
    		[PMID: 29553260]
    HepG2 IC50
    30.9 μM
    Compound: 32
    Cytotoxicity against human HepG2 cells by MTT assay
    Cytotoxicity against human HepG2 cells by MTT assay
    		[PMID: 21726077]
    HepG2 EC50
    4.63 μM
    Compound: QE
    Antioxidant activity in human HepG2 cells assessed as decrease in fluorescence level after 2.5 hrs measured every 5 mins for 1 hr by DCFH-DA staining based fluorescence assay
    Antioxidant activity in human HepG2 cells assessed as decrease in fluorescence level after 2.5 hrs measured every 5 mins for 1 hr by DCFH-DA staining based fluorescence assay
    		[PMID: 26974372]
    HepG2 IC50
    65 μM
    Compound: Quercetin
    Antioxidant activity in human HepG2 cells assessed as inhibition of cumene hydroperoxide-mediated lipid peroxidation incubated for 60 mins followed by cumOOH addition for 60 mins measured for 60 mins by C11-BODIPY probe based fluorescence assay
    Antioxidant activity in human HepG2 cells assessed as inhibition of cumene hydroperoxide-mediated lipid peroxidation incubated for 60 mins followed by cumOOH addition for 60 mins measured for 60 mins by C11-BODIPY probe based fluorescence assay
    		[PMID: 29553260]
    HepG2 2.2.15 CC50
    38.1 μM
    Compound: quercetin
    Cytotoxicity against human HepG2(2.2.15) cells after 8 days by MTT assay
    Cytotoxicity against human HepG2(2.2.15) cells after 8 days by MTT assay
    		[PMID: 21401115]
    HL-60 IC50
    > 10 μg/mL
    Compound: 8
    Cytotoxicity against human HL60 cells after 3 days by MTT assay
    Cytotoxicity against human HL60 cells after 3 days by MTT assay
    		[PMID: 11421746]
    HL-60 IC50
    10 ng/mL
    Compound: Quercetin
    Growth inhibition of human HL60 cells after 72 hrs by MTT assay
    Growth inhibition of human HL60 cells after 72 hrs by MTT assay
    		[PMID: 31398616]
    HL-60 IC50
    47 μM
    Compound: Quercetin
    Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
    		[PMID: 25014747]
    HL-60 IC50
    58 μM
    Compound: Quercetin
    Cytotoxicity against human HL60 cells after 46 hrs by MTT assay
    Cytotoxicity against human HL60 cells after 46 hrs by MTT assay
    		[PMID: 23756061]
    HOP-62 IC50
    7.52 μM
    Compound: 1
    Anticancer activity against human HOP62 cells by HTS assay
    Anticancer activity against human HOP62 cells by HTS assay
    		[PMID: 25139569]
    HS27 EC50
    > 100 μM
    Compound: Quercetin
    Antiproliferative activity against human HS27 cells after 24 hrs by MTT assay
    Antiproliferative activity against human HS27 cells after 24 hrs by MTT assay
    		[PMID: 21090565]
    HT-22 EC50
    11.52 μM
    Compound: Quercetin
    Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
    Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
    		[PMID: 24602904]
    HT-22 EC50
    3.13 μM
    Compound: Quercetin
    Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay
    Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay
    		[PMID: 24602904]
    HT-29 IC50
    15.4 μM
    Compound: Quercetin
    Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins
    Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins
    		[PMID: 24900447]
    HT-29 IC50
    18 μM
    Compound: Quer
    Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    HT-29 EC50
    8.02 μM
    Compound: Quercetin
    Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay
    Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay
    		[PMID: 24900447]
    Huh-7 CC50
    > 50 μM
    Compound: 35
    Cytotoxicity against human Huh7.5.1 cells by MTT assay
    Cytotoxicity against human Huh7.5.1 cells by MTT assay
    		[PMID: 22445328]
    Huh-7 EC50
    19.8 μM
    Compound: 35
    Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay
    Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay
    		[PMID: 22445328]
    J774.2 IC50
    125.44 μM
    Compound: 2
    Cytotoxicity against BALB/c mouse J774.2 cells after 72 hrs by trypan blue assay
    Cytotoxicity against BALB/c mouse J774.2 cells after 72 hrs by trypan blue assay
    		[PMID: 19489596]
    J774.A1 IC50
    49.1 μM
    Compound: 1
    Inhibition of LPS-induced NO production in mouse J774.A1 cells pre-incubated with compound for 1 hr followed by LPS stimulation for 24 hrs by ELISA assay
    Inhibition of LPS-induced NO production in mouse J774.A1 cells pre-incubated with compound for 1 hr followed by LPS stimulation for 24 hrs by ELISA assay
    		[PMID: 34971873]
    Jurkat IC50
    2 μM
    Compound: Quercetin
    Inhibition of chymotrypsin-like activity of human 26S proteasome in human Jurkat cells assessed as decrease in AMC hydrolysis using Z-Gly-Gly-Leu-AMC as substrate after 24 hrs by fluorescence based method
    Inhibition of chymotrypsin-like activity of human 26S proteasome in human Jurkat cells assessed as decrease in AMC hydrolysis using Z-Gly-Gly-Leu-AMC as substrate after 24 hrs by fluorescence based method
    		[PMID: 30776692]
    Jurkat IC50
    3.5 μM
    Compound: Quercetin
    Inhibition of chymotrypsin-like activity of purified human 20S proteasome expressed in human Jurkat cells assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 2 hrs by fluorescence based method
    Inhibition of chymotrypsin-like activity of purified human 20S proteasome expressed in human Jurkat cells assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 2 hrs by fluorescence based method
    		[PMID: 30776692]
    K562 IC50
    2.5 μM
    Compound: Quercetin
    Cytotoxicity against human K562 cells assessed as inhibition of cell growth after 5 days by MTT assay
    Cytotoxicity against human K562 cells assessed as inhibition of cell growth after 5 days by MTT assay
    		[PMID: 29553260]
    L6 IC50
    > 30 μg/mL
    Compound: 17
    Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells after 96 hrs by photometric method
    Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells after 96 hrs by photometric method
    		10.1039/C5MD00481K
    L929 IC50
    > 100 μM
    Compound: Quercetin
    Cytotoxicity against mouse L929 cells after 5 days by MTS assay
    Cytotoxicity against mouse L929 cells after 5 days by MTS assay
    		[PMID: 22743241]
    L929 EC50
    20 μM
    Compound: quercetin
    Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining
    Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining
    		[PMID: 9287415]
    L929 EC50
    26 μM
    Compound: quercetin
    Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay
    Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay
    		[PMID: 9287415]
    LN-229 IC50
    12 μM
    Compound: Quer
    Cytotoxicity against human LN229 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human LN229 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    LNCaP EC50
    25 μM
    Compound: 2, quercetin
    Decrease in androgen receptor protein expression in LNCaP cells by Western blotting
    Decrease in androgen receptor protein expression in LNCaP cells by Western blotting
    		[PMID: 17383188]
    LNCaP IC50
    45.46 μM
    Compound: 1
    Antiproliferative activity against human LNCAP cells after 3 days by WST-1 assay
    Antiproliferative activity against human LNCAP cells after 3 days by WST-1 assay
    		[PMID: 28760528]
    LNCaP IC50
    45.5 μM
    Compound: Quercetin
    Antiproliferative activity against human LNCAP cells after 3 days by WST-1 assay
    Antiproliferative activity against human LNCAP cells after 3 days by WST-1 assay
    		[PMID: 30165345]
    LNCaP IC50
    45.5 μM
    Compound: 1
    Antiproliferative activity against human LNCAP cells after 3 days by WST1 assay
    Antiproliferative activity against human LNCAP cells after 3 days by WST1 assay
    		[PMID: 27476422]
    LNCaP IC50
    45.5 μM
    Compound: Quercetin
    Cytotoxicity against human androgen-dependent LNCAP cells assessed as inhibition of cell viability after 3 days by WST-1 cell proliferation assay
    Cytotoxicity against human androgen-dependent LNCAP cells assessed as inhibition of cell viability after 3 days by WST-1 cell proliferation assay
    		[PMID: 26341135]
    LOX IMVI IC50
    4.65 μM
    Compound: 1
    Anticancer activity against human LOXIMVI cells by HTS assay
    Anticancer activity against human LOXIMVI cells by HTS assay
    		[PMID: 25139569]
    M14 IC50
    12.77 μM
    Compound: 1
    Anticancer activity against human M14 cells by HTS assay
    Anticancer activity against human M14 cells by HTS assay
    		[PMID: 25139569]
    MCF-10A IC50
    11.97 μM
    Compound: Quercetin
    Cytotoxicity against human MCF10A cells assessed as decrease in cell viability after 3 days by WST-1 assay
    Cytotoxicity against human MCF10A cells assessed as decrease in cell viability after 3 days by WST-1 assay
    		[PMID: 30165345]
    MCF7 IC50
    > 10 μM
    Compound: quercetin
    Cytotoxicity against human MCF7 cells by MTT assay
    Cytotoxicity against human MCF7 cells by MTT assay
    		[PMID: 19583252]
    MCF7 EC50
    > 100 μM
    Compound: Quercetin
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
    		[PMID: 21090565]
    MCF7 IC50
    19.5 mg/mL
    Compound: 18
    Cytotoxicity against human MCF7 cells after 3 days by SRB assay
    Cytotoxicity against human MCF7 cells after 3 days by SRB assay
    		[PMID: 15568778]
    MCF7 IC50
    20.9 μM
    Compound: 1, Que
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 25906385]
    MCF7 IC50
    5 μM
    Compound: Quercetin
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 6 days by SRB assay
    		[PMID: 33257172]
    MCF7 IC50
    7.6 μM
    Compound: 13
    Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining
    Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining
    		[PMID: 21354800]
    MDA-MB-231 IC50
    20 μM
    Compound: Quer
    Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    MDCK CC50
    253.8 μM
    Compound: 4
    Cytotoxicity against MDCK cells after 48 hrs by MTT assay
    Cytotoxicity against MDCK cells after 48 hrs by MTT assay
    		[PMID: 19729316]
    MDCK CC50
    253.8 μM
    Compound: QR
    Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by MTT assay
    		[PMID: 31744778]
    MDCK ED50
    48.2 μM
    Compound: 1
    Antiviral activity against influenza A virus (A/swine/OH/511445/2007(H1N1)) Oh7 infected in MDCK cells assessed as inhibition of viral replication after 4 days by quantitative RT-PCR
    Antiviral activity against influenza A virus (A/swine/OH/511445/2007(H1N1)) Oh7 infected in MDCK cells assessed as inhibition of viral replication after 4 days by quantitative RT-PCR
    		[PMID: 22115591]
    MDCK IC50
    6.9 μM
    Compound: 13
    Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining
    Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining
    		[PMID: 21354800]
    MDCK EC50
    84.46 nM
    Compound: QR
    Antiviral activity against Influenza A virus (H1N1) infected in dog MDCK cells assessed as reduction in log2HA titer incubated for 3 to 4 days by CPE assay
    Antiviral activity against Influenza A virus (H1N1) infected in dog MDCK cells assessed as reduction in log2HA titer incubated for 3 to 4 days by CPE assay
    		[PMID: 31744778]
    Monocyte IC50
    120 μM
    Compound: quercetin
    Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
    Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA
    		[PMID: 10096854]
    MSTO-211H GI50
    > 20 μM
    Compound: Quercetin
    Growth inhibition of human MSTO-211H cells incubated for 72 hrs by trypan blue assay
    Growth inhibition of human MSTO-211H cells incubated for 72 hrs by trypan blue assay
    		[PMID: 32435372]
    MV4-11 GI50
    13.1 μM
    Compound: 6
    Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay
    Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay
    		[PMID: 23411073]
    N9 IC50
    10.22 μM
    Compound: 2
    Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 28073678]
    NALM-6 IC50
    77.1 μM
    Compound: Quercetin
    Cytotoxicity against human NALM6 cells after 46 hrs by MTT assay
    Cytotoxicity against human NALM6 cells after 46 hrs by MTT assay
    		[PMID: 23756061]
    NCI/ADR-RES IC50
    22.15 μM
    Compound: 1, Que
    Cytotoxicity against human MCF7/ADR cells assessed as cell growth inhibition after 72 hrs by MTT assay
    Cytotoxicity against human MCF7/ADR cells assessed as cell growth inhibition after 72 hrs by MTT assay
    		[PMID: 25906385]
    NCI-H1299 IC50
    13.6 μM
    Compound: 1
    Anticancer activity against human H1299 cells by HTS assay
    Anticancer activity against human H1299 cells by HTS assay
    		[PMID: 25139569]
    NCI-H157 IC50
    6 μM
    Compound: 1
    Anticancer activity against human NCI-H157 cells by HTS assay
    Anticancer activity against human NCI-H157 cells by HTS assay
    		[PMID: 25139569]
    NCI-H1792 IC50
    3.85 μM
    Compound: 1
    Anticancer activity against human NCI-H1792 cells by HTS assay
    Anticancer activity against human NCI-H1792 cells by HTS assay
    		[PMID: 25139569]
    NCI-H1944 IC50
    10.18 μM
    Compound: 1
    Anticancer activity against human NCI-H1944 cells by HTS assay
    Anticancer activity against human NCI-H1944 cells by HTS assay
    		[PMID: 25139569]
    NCI-H460 IC50
    12 μM
    Compound: Quer
    Cytotoxicity against human NCI-H460 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    NCI-H460 IC50
    9.62 μM
    Compound: 1
    Anticancer activity against human H460 cells by HTS assay
    Anticancer activity against human H460 cells by HTS assay
    		[PMID: 25139569]
    NCI-H522 IC50
    5.77 μM
    Compound: 1
    Anticancer activity against human NCI-H522 cells by HTS assay
    Anticancer activity against human NCI-H522 cells by HTS assay
    		[PMID: 25139569]
    Neutrophil IC50
    0.7 μM
    Compound: 4i
    Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of HOCl-induced oxidation of APF after 6 mins by fluorescence assay
    Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of HOCl-induced oxidation of APF after 6 mins by fluorescence assay
    		[PMID: 23871908]
    Neutrophil IC50
    1.8 μM
    Compound: 7
    Inhibition of PMA-induced oxidative burst in human neutrophils by APF assay
    Inhibition of PMA-induced oxidative burst in human neutrophils by APF assay
    		[PMID: 25151578]
    Neutrophil IC50
    11.3 μM
    Compound: 4i
    Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay
    Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay
    		[PMID: 23871908]
    Neutrophil IC50
    2.4 μM
    Compound: Quercetin
    Inhibition of immune complex-stimulated neutrophil oxidative metabolism in New Zealand white rabbit neutrophils assessed as ROS generation after 30 mins by luminol enhanced chemiluminescence assay
    Inhibition of immune complex-stimulated neutrophil oxidative metabolism in New Zealand white rabbit neutrophils assessed as ROS generation after 30 mins by luminol enhanced chemiluminescence assay
    		[PMID: 17804122]
    Neutrophil IC50
    2.7 μM
    Compound: 7
    Inhibition of PMA-induced oxidative burst in human neutrophils by amplex red assay
    Inhibition of PMA-induced oxidative burst in human neutrophils by amplex red assay
    		[PMID: 25151578]
    Neutrophil IC50
    2.8 μM
    Compound: 7
    Inhibition of PMA-induced oxidative burst in human neutrophils by chemiluminescence assay
    Inhibition of PMA-induced oxidative burst in human neutrophils by chemiluminescence assay
    		[PMID: 25151578]
    Neutrophil IC50
    20.4 μM
    Compound: Quercetin
    Antiinflammatory activity against LPS-stimulated human neutrophils assessed as reduction in TNFalpha production incubated for 1 hr followed by LPS stimulation measured after 18 to 24 hrs by ELISA
    Antiinflammatory activity against LPS-stimulated human neutrophils assessed as reduction in TNFalpha production incubated for 1 hr followed by LPS stimulation measured after 18 to 24 hrs by ELISA
    		[PMID: 30109803]
    Neutrophil IC50
    26 μM
    Compound: 4i
    Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of ROS-induced luminol oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay
    Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of ROS-induced luminol oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay
    		[PMID: 23871908]
    Neutrophil IC50
    33 μM
    Compound: Quercetin
    Antiinflammatory activity against LPS-stimulated human neutrophils assessed as reduction in IL-8 production incubated for 1 hr followed by LPS stimulation measured after 18 to 24 hrs by ELISA
    Antiinflammatory activity against LPS-stimulated human neutrophils assessed as reduction in IL-8 production incubated for 1 hr followed by LPS stimulation measured after 18 to 24 hrs by ELISA
    		[PMID: 30109803]
    Neutrophil IC50
    4.4 μM
    Compound: Quercetin
    Antiinflammatory activity against f-MLP-stimulated human neutrophils assessed as reduction in ROS production incubated for 40 mins measured at intervals of 2 mins by luminol-dependent chemiluminescence assay
    Antiinflammatory activity against f-MLP-stimulated human neutrophils assessed as reduction in ROS production incubated for 40 mins measured at intervals of 2 mins by luminol-dependent chemiluminescence assay
    		[PMID: 30109803]
    Neutrophil IC50
    4.7 μM
    Compound: Quercetin
    Inhibition of immune complex-stimulated neutrophil oxidative metabolism in New Zealand white rabbit neutrophils assessed as ROS generation after 30 mins by lucigenin enhanced chemiluminescence assay
    Inhibition of immune complex-stimulated neutrophil oxidative metabolism in New Zealand white rabbit neutrophils assessed as ROS generation after 30 mins by lucigenin enhanced chemiluminescence assay
    		[PMID: 17804122]
    Neutrophil IC50
    4.86 μM
    Compound: Quercetin
    Antioxidant activity in human neutrophils assessed as inhibition of oxidative burst-induced ROS production by chemiluminescence assay
    Antioxidant activity in human neutrophils assessed as inhibition of oxidative burst-induced ROS production by chemiluminescence assay
    		[PMID: 24588269]
    Neutrophil IC50
    8 μM
    Compound: 4i
    Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of H2O2-induced oxidation of amplex red incubated for 5 mins prior to PMA challenge by fluorescence assay
    Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of H2O2-induced oxidation of amplex red incubated for 5 mins prior to PMA challenge by fluorescence assay
    		[PMID: 23871908]
    NHDF IC50
    > 50 μM
    Compound: 34
    Cytotoxicity against NHDF assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against NHDF assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 28671460]
    PANC-1 IC50
    62 μM
    Compound: Quer
    Cytotoxicity against human PANC1 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human PANC1 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    PC-12 EC50
    58.4 μM
    Compound: Quercetin
    Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay
    Neuroprotective activity against H2O2-induced injury in rat PC12 cells treated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay
    		[PMID: 19673490]
    PC-12 EC50
    68.3 μM
    Compound: Quercetin
    Cytoprotective activity against H2O2-induced cell death in rat PC12 cells assessed as increase in cell viability preincubated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay
    Cytoprotective activity against H2O2-induced cell death in rat PC12 cells assessed as increase in cell viability preincubated 2 hrs before H2O2 challenge measured after 4 hrs by MTT assay
    		[PMID: 19362850]
    PC-3 IC50
    > 100 μM
    Compound: Quercetin
    Antiproliferative activity against human PC3 cells after 3 days by WST-1 assay
    Antiproliferative activity against human PC3 cells after 3 days by WST-1 assay
    		[PMID: 30165345]
    PC-3 IC50
    > 100 μM
    Compound: 1
    Antiproliferative activity against human PC3 cells after 3 days by WST-1 assay
    Antiproliferative activity against human PC3 cells after 3 days by WST-1 assay
    		[PMID: 28760528]
    PC-3 IC50
    > 100 μM
    Compound: 1
    Antiproliferative activity against human PC3 cells after 3 days by WST1 assay
    Antiproliferative activity against human PC3 cells after 3 days by WST1 assay
    		[PMID: 27476422]
    PC-3 IC50
    > 100 μM
    Compound: Quercetin
    Cytotoxicity against human androgen-independent PC3 cells assessed as cell cell viability after 3 days by WST-1 cell proliferation assay
    Cytotoxicity against human androgen-independent PC3 cells assessed as cell cell viability after 3 days by WST-1 cell proliferation assay
    		[PMID: 26341135]
    Peritoneal macrophage IC50
    36 μM
    Compound: kp20
    Inhibition of LPS-stimulated nitric oxide production in ddy mouse peritoneal macrophages measured after 20 hrs by Greiss method
    Inhibition of LPS-stimulated nitric oxide production in ddy mouse peritoneal macrophages measured after 20 hrs by Greiss method
    		[PMID: 27955927]
    Peritoneal macrophage cell IC50
    > 100 μM
    Compound: quercetin
    Cytotoxicity against mouse Peritoneal macrophages cells after 72 hrs by MTS assay
    Cytotoxicity against mouse Peritoneal macrophages cells after 72 hrs by MTS assay
    		[PMID: 22989363]
    Peritoneal macrophage cell IC50
    80.2 μM
    Compound: 1
    Cytotoxicity against Swiss mouse peritoneal macrophages after 72 hrs by AlamarBlue assay
    Cytotoxicity against Swiss mouse peritoneal macrophages after 72 hrs by AlamarBlue assay
    		[PMID: 23876028]
    PWR-1E IC50
    15.08 μM
    Compound: Quercetin
    Cytotoxicity against human PWR-1E cells assessed as decrease in cell viability after 3 days by WST-1 assay
    Cytotoxicity against human PWR-1E cells assessed as decrease in cell viability after 3 days by WST-1 assay
    		[PMID: 30165345]
    RAW264.7 CC50
    > 50 μM
    Compound: Quercetin
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 26928174]
    RAW264.7 IC50
    > 50 μM
    Compound: 15
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by griess reaction analysis
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 18 hrs by griess reaction analysis
    		[PMID: 24679441]
    RAW264.7 IC50
    1.3 μM
    Compound: Quercetin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs
    		[PMID: 23540981]
    RAW264.7 IC50
    1.8 μM
    Compound: Quercetin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production incubated for 24 hrs by Griess reagent based assay
    		[PMID: 26143931]
    RAW264.7 IC50
    11.4 μM
    Compound: 9
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method
    		[PMID: 19778086]
    RAW264.7 IC50
    15 μM
    Compound: Quercetin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by Griess assay
    		[PMID: 26928174]
    RAW264.7 IC50
    15.1 μM
    Compound: Quercetin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by Griess assay
    		[PMID: 32003565]
    RAW264.7 IC50
    15.9 μM
    Compound: Quercetin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess assay
    		[PMID: 27177824]
    RAW264.7 IC50
    16.4 μM
    Compound: Quercetin
    Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reaction analysis
    Inhibition of iNOS-mediated nitric oxide production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reaction analysis
    		[PMID: 23517145]
    RAW264.7 IC50
    16.6 μM
    Compound: Quercetin
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production incubated for 24 hrs by Griess reagent based assay
    Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production incubated for 24 hrs by Griess reagent based assay
    		[PMID: 25245917]
    RAW264.7 IC50
    2.9 μg/mL
    Compound: Quercetin
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as reduction in nitric oxide production after 24 hrs by Griess method based ELISA
    Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as reduction in nitric oxide production after 24 hrs by Griess method based ELISA
    		[PMID: 25106885]
    RAW264.7 IC50
    22.7 μM
    Compound: Quercetin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells by Griess reagent based assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells by Griess reagent based assay
    		[PMID: 32118424]
    RAW264.7 IC50
    25 μM
    Compound: quercetin
    Inhibition of LPS and INF-alpha-induced nitric oxide production in mouse RAW264.7 cells after 16 hrs
    Inhibition of LPS and INF-alpha-induced nitric oxide production in mouse RAW264.7 cells after 16 hrs
    		[PMID: 18027905]
    RAW264.7 IC50
    32.1 μM
    Compound: quercetin
    Antiinflammatory activity against mouse RAW264.7 cells assessed as Inhibition of LPS-induced nitric oxide production after 24 hrs by ELISA
    Antiinflammatory activity against mouse RAW264.7 cells assessed as Inhibition of LPS-induced nitric oxide production after 24 hrs by ELISA
    		[PMID: 20121165]
    RAW264.7 IC50
    34.5 μM
    Compound: Quercetin
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs
    		[PMID: 20825224]
    RAW264.7 IC50
    4.2 μM
    Compound: Quercetin
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by alamarBlue assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by alamarBlue assay
    		[PMID: 32357011]
    RAW264.7 IC50
    4.41 μM
    Compound: Quercetin
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess assay
    Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess assay
    		[PMID: 28427811]
    RAW264.7 IC50
    4.53 μM
    Compound: Quercetin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of NO production preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess reagent based assay
    		[PMID: 32299661]
    RAW264.7 IC50
    54.3 μM
    Compound: Quercetin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by Griess reagent method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by Griess reagent method
    		[PMID: 20056545]
    RAW264.7 IC50
    63 μM
    Compound: 8
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method
    		[PMID: 21353543]
    RAW264.7 IC50
    66.6 μM
    Compound: 8
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion after 18 hrs
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha secretion after 18 hrs
    		[PMID: 21353543]
    RAW264.7 IC50
    9.6 μM
    Compound: quercetin
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess reagent assay
    		[PMID: 19555124]
    RAW264.7 IC50
    95.6 μM
    Compound: quercetin
    Cytotoxicity against mouse RAW264.7 cells after 72 hrs by MTS assay
    Cytotoxicity against mouse RAW264.7 cells after 72 hrs by MTS assay
    		[PMID: 22989363]
    RF/6A IC50
    40 μM
    Compound: Quercetin
    Antimigratory activity in rhesus monkey RF/6A cells measured after 24 hrs by wound assay
    Antimigratory activity in rhesus monkey RF/6A cells measured after 24 hrs by wound assay
    		[PMID: 27015547]
    RF/6A IC50
    70 μM
    Compound: Quercetin
    Antiproliferative activity in rhesus monkey RF/6A cells measured after 24 to 72 hrs by MTT assay
    Antiproliferative activity in rhesus monkey RF/6A cells measured after 24 to 72 hrs by MTT assay
    		[PMID: 27015547]
    RS4-11 GI50
    21.6 μM
    Compound: 6
    Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay
    Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay
    		[PMID: 23411073]
    Sf21 IC50
    28.6 μM
    Compound: 5
    Inhibition of human recombinant COX2 expressed in insect Sf21 cells by EIA assay
    Inhibition of human recombinant COX2 expressed in insect Sf21 cells by EIA assay
    		[PMID: 17378609]
    SGC-7901 IC50
    7.878 μg/mL
    Compound: Compound 4
    Cytotoxicity against human SGC7901 cells by MTT assay
    Cytotoxicity against human SGC7901 cells by MTT assay
    		[PMID: 25862199]
    SK-MEL-2 IC50
    > 10 μM
    Compound: 10
    Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay
    Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay
    		[PMID: 28165740]
    SK-MEL-2 IC50
    12 μM
    Compound: Quer
    Cytotoxicity against human SK-MEL-2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human SK-MEL-2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    SK-OV-3 IC50
    > 10 μM
    Compound: 10
    Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
    Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
    		[PMID: 28165740]
    SW1573 IC50
    > 10 μg/mL
    Compound: 8
    Cytotoxicity against human SW1573 cells after 3 days by MTT assay
    Cytotoxicity against human SW1573 cells after 3 days by MTT assay
    		[PMID: 11421746]
    T47D IC50
    11 μM
    Compound: Quer
    Cytotoxicity against human T47D cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human T47D cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    U-251 IC50
    77.8 μM
    Compound: 51
    Inhibition of cell proliferation of human U251 cells assessed as cell viability after 72 hrs by sulforhodamine B assay
    Inhibition of cell proliferation of human U251 cells assessed as cell viability after 72 hrs by sulforhodamine B assay
    		[PMID: 25442304]
    U2OS EC50
    5.93 μM
    Compound: Quercetin
    Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay
    Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay
    		[PMID: 24900447]
    U-87MG ATCC IC50
    23 μM
    Compound: Quer
    Cytotoxicity against human U87 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human U87 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    Vero IC50
    110 μg/mL
    Compound: 5
    Cytotoxicity against african green monkey Vero cells by MTT assay
    Cytotoxicity against african green monkey Vero cells by MTT assay
    		[PMID: 18855442]
    Vero CC50
    3.32 mM
    Compound: 14
    Cytotoxicity against african green monkey Vero cells incubated for 3 days
    Cytotoxicity against african green monkey Vero cells incubated for 3 days
    		[PMID: 32539378]
    Vero C1008 CC50
    3.32 μM
    Compound: 41
    Cytotoxicity against African green monkey Vero E6 cells by MTT assay
    Cytotoxicity against African green monkey Vero E6 cells by MTT assay
    		[PMID: 33486200]
    WM-115 IC50
    177.5 μM
    Compound: Quercetin
    Cytotoxicity against human WM115 cells after 46 hrs by MTT assay
    Cytotoxicity against human WM115 cells after 46 hrs by MTT assay
    		[PMID: 23756061]
    體外研究
    (In Vitro)

    Quercetin 是一種植物性化學(xué)物質(zhì)或植物化學(xué)物質(zhì)，用作補(bǔ)充劑、飲料或食品的成分。在幾項(xiàng)研究中，它可能具有抗炎和抗氧化特性，并且正在研究它的廣泛潛在健康益處。Quercetin 是一種 PI3K 抑制劑，IC50 為 2.4-5.4 μM。Quercetin 強(qiáng)烈抑制 PI3K 和 Src 激酶，輕度抑制 Akt1/2，并輕微影響 PKC、p38 和 ERK1/2[1]。Quercetin 抑制 TNF 誘導(dǎo)的 LDH% 釋放、EC 依賴性中性粒細(xì)胞與牛肺動脈內(nèi)皮細(xì)胞 (BPAEC) 的粘附以及 BPAEC DNA 合成和增殖[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Quercetin (75 mg/kg) 和 2-甲氧基雌二醇的組合增強(qiáng)了對人前列腺癌 LNCaP 和 PC-3 細(xì)胞異種移植腫瘤生長的抑制[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    302.24

    Formula

    C15H10O7
    CAS 號
    性狀

    固體

    顏色

    Light yellow to green yellow

    中文名稱

    槲皮素；櫟精；槲皮黃素
    結(jié)構(gòu)分類
    初始來源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 100 mg/mL (330.86 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    Ethanol 中的溶解度 : 16.67 mg/mL (55.15 mM; 超聲助溶)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 3.3086 mL 16.5431 mL 33.0863 mL
    5 mM 0.6617 mL 3.3086 mL 6.6173 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C儲存時，請?jiān)?年內(nèi)使用， -20°C儲存時，請?jiān)?個月內(nèi)使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實(shí)驗(yàn)：

    請根據(jù)您的 實(shí)驗(yàn)動物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

    以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
    ——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (8.27 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

      生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
    • 方案 二

      請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (8.27 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

      2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。

    以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

    • 方案 一

      請依序添加每種溶劑： 0.5% CMC-Na/saline water

      Solubility: 25 mg/mL (82.72 mM); 懸濁液; 超聲助溶

    • 方案 二

      請依序添加每種溶劑： 50% Propylene glycol    50% Saline

      Solubility: 10 mg/mL (33.09 mM); 懸濁液; 超聲助溶

    動物溶解方案計(jì)算器
    請輸入動物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
    請輸入您的動物體內(nèi)配方組成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
    方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購。 ，Tween 80，均可在 MCE 網(wǎng)站選購。
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    儲備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
    您所需的儲備液濃度超過該產(chǎn)品的實(shí)測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
    動物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
    連續(xù)給藥周期超過半月以上，請謹(jǐn)慎選擇該方案。
    請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 99.80%

    參考文獻(xiàn)
    Animal Administration
    [3]

    Mice are inoculated subcutaneously with 5×105?PC-3 cells suspended in 100μL PBS and 2×108?LNCaP cells suspended in 100μL of matrigel and PBS mixture (1:1) on the right back. When xenograft tumors reach a volume of approximately 100 mm3, mice are randomLy assigned to four groups (n=8 each group) and treated intraperitoneally. Therapeutic schedule based on our in vitro results, preliminary experiments and many other researchers' studies is as follows: (1) Vehicle control group: vehicle of quercetin on day 1, vehicle of 2-ME on day 2, (2) Quercetin treated group: quercetin 75 mg/kg on day 1, vehicle of 2-ME on day 2, (3) 2-ME treated group: vehicle of quercetin on day 1, 2-ME 150 mg/kg on day 2, (4) Combination treatment group: quercetin 75 mg/kg on day 1, 2-ME 150 mg/kg on day 2. Two days is a treatment cycle and the whole treatment process lasted for 4 weeks. Tumor sizes are monitored every 2 days using caliper and tumor volume are calculated according to the formula: L×S2×0.5, in which L represents the longest diameter and S represents the shortest diameter of tumor. Mice are weighed as well. At the end of treatment procedure, on day 29, mice are anesthetized with chloral hydrate and sacrificed by cervical dislocation. Xenograft tumors are taken out quickly and weighed. One part of it is put into liquid nitrogen immediately for future biomarker analysis and the other part is fixed in 10% neutral buffered formalin for immunohistochemical analysis. Serum biochemical parameters such as ALT, AST, creatinine and urea nitrogen that reflected drug toxicity are also detected.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    參考文獻(xiàn)

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C儲存時，請?jiān)?年內(nèi)使用， -20°C儲存時，請?jiān)?個月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 3.3086 mL 16.5431 mL 33.0863 mL 82.7157 mL
    5 mM 0.6617 mL 3.3086 mL 6.6173 mL 16.5431 mL
    10 mM 0.3309 mL 1.6543 mL 3.3086 mL 8.2716 mL
    15 mM 0.2206 mL 1.1029 mL 2.2058 mL 5.5144 mL
    20 mM 0.1654 mL 0.8272 mL 1.6543 mL 4.1358 mL
    25 mM 0.1323 mL 0.6617 mL 1.3235 mL 3.3086 mL
    30 mM 0.1103 mL 0.5514 mL 1.1029 mL 2.7572 mL
    40 mM 0.0827 mL 0.4136 mL 0.8272 mL 2.0679 mL
    50 mM 0.0662 mL 0.3309 mL 0.6617 mL 1.6543 mL
    DMSO 60 mM 0.0551 mL 0.2757 mL 0.5514 mL 1.3786 mL
    80 mM 0.0414 mL 0.2068 mL 0.4136 mL 1.0339 mL
    100 mM 0.0331 mL 0.1654 mL 0.3309 mL 0.8272 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    產(chǎn)品名稱：
    Quercetin
    目錄號：
    HY-18085
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