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  2. Anti-infection Autophagy
  3. Bacterial Autophagy Antibiotic Parasite
  4. Azithromycin

Azithromycin  (Synonyms: 阿奇霉素; CP 62993)

目錄號(hào): HY-17506 純度: ≥98.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Azithromycin (CP-62993) 是一種大環(huán)內(nèi)酯抗生素，常用于細(xì)菌感染的研究。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Azithromycin Chemical Structure

Azithromycin Chemical Structure

CAS No. : 83905-01-5

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥880
In-stock
50 mg ￥800
In-stock
100 mg ￥1250
In-stock
200 mg ￥2000
In-stock
500 mg ￥3800
In-stock
1 g   詢價(jià)  
5 g   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of Azithromycin:

  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Azithromycin is a macrolide antibiotic useful for the treatment of a number of bacterial infections.

IC50 & Target

Macrolide

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 CC50
> 600 μM
Compound: Azithromycin
Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
[PMID: 32871342]
HeLa IC50
160 μg/mL
Compound: Azithromycin
Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs
Inhibition of metabolic activity in HeLa cells assessed as MTT reduction after 48 hrs
[PMID: 17088489]
HeLa IC50
240 μg/mL
Compound: Azithromycin
Antiproliferative effect against HeLa cells after 48 hrs
Antiproliferative effect against HeLa cells after 48 hrs
[PMID: 17088489]
HepG2 IC50
> 50 μM
Compound: 6
Cytotoxicity against human HepG2 cells after 1 to 4 hrs by MTS assay
Cytotoxicity against human HepG2 cells after 1 to 4 hrs by MTS assay
[PMID: 21476508]
HepG2 IC50
> 50 μM
Compound: 1
Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
[PMID: 22148880]
HepG2 IC50
203 μM
Compound: AZI
Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
[PMID: 22380766]
HepG2 IC50
203 μM
Compound: AZ
Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay
[PMID: 22321992]
HFF CC50
174 μM
Compound: 3
Cytotoxicity against HFF after 48 hrs by MTS assay
Cytotoxicity against HFF after 48 hrs by MTS assay
[PMID: 21428405]
MG-63 IC50
180 μg/mL
Compound: Azithromycin
Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs
Inhibition of metabolic activity in MG63 cells assessed as MTT reduction after 48 hrs
[PMID: 17088489]
MG-63 IC50
190 μg/mL
Compound: Azithromycin
Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs
Antiproliferative effect against MG63 cells assessed as BrdU incorporation into DNA after 48 hrs after 48 hrs
[PMID: 17088489]
Osteoblast IC50
160 μg/mL
Compound: Azithromycin
Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs
Inhibition of metabolic activity in primary human osteoblasts assessed as MTT reduction after 48 hrs
[PMID: 17088489]
Osteoblast IC50
25 μg/mL
Compound: Azithromycin
Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs
Antiproliferative effect against primary human osteoblasts assessed as BrdU incorporation into DNA after 48 hrs
[PMID: 17088489]
THP-1 IC50
> 50 μM
Compound: 6
Cytotoxicity against human THP1 cells after 1 to 4 hrs by MTS assay
Cytotoxicity against human THP1 cells after 1 to 4 hrs by MTS assay
[PMID: 21476508]
THP-1 EC50
0.024 mg/L
Compound: Azithromycin
Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 infected in human THP1 cells assessed as decrease of CFU after 24 hrs
Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 infected in human THP1 cells assessed as decrease of CFU after 24 hrs
[PMID: 19564365]
THP-1 EC50
2.86 mg/L
Compound: Azithromycin
Antibacterial activity against methicillin-sensitive Listeria monocytogenes EGD infected in human THP1 cells assessed as decrease of CFU after 24 hrs
Antibacterial activity against methicillin-sensitive Listeria monocytogenes EGD infected in human THP1 cells assessed as decrease of CFU after 24 hrs
[PMID: 19564365]
Vero CC50
> 130 μM
Compound: Azithromycin
Cytotoxicity against African green monkey Vero cells by MTT assay
Cytotoxicity against African green monkey Vero cells by MTT assay
[PMID: 32871342]
Vero CC50
> 40 μM
Compound: Azithromycin
Cytotoxicity against African green monkey Vero cells by Celltiter blue assay
Cytotoxicity against African green monkey Vero cells by Celltiter blue assay
[PMID: 32871342]
Vero CC50
810 μM
Compound: Azithromycin
Antiproliferative against African green monkey Vero cells incubated for 40 hrs by Celltiter assay
Antiproliferative against African green monkey Vero cells incubated for 40 hrs by Celltiter assay
[PMID: 32871342]
Vero C1008 CC50
> 40 μM
Compound: Azithromycin
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
10.1101/2020.04.03.023846
Vero C1008 EC50
2.12 μM
Compound: Azithromycin
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
10.1101/2020.04.03.023846
體外研究
(In Vitro)

阿奇霉素 (2 μM) 可增強(qiáng)哮喘患者原發(fā)性支氣管上皮細(xì)胞中鼻病毒誘導(dǎo)的 IFNβ 表達(dá)，這與 RIG-I 樣受體的過度表達(dá)和病毒復(fù)制的抑制有關(guān)。敲低 MDA5（而非敲低 RIG-I）可降低阿奇霉素 (2 μM) 增強(qiáng)的病毒誘導(dǎo)的哮喘原發(fā)性支氣管上皮細(xì)胞中 IFNβ 表達(dá)[1]。阿奇霉素可特異性降低內(nèi)毒素刺激的單核細(xì)胞 THP-1 細(xì)胞中的 MMP-9 mRNA 和蛋白質(zhì)水平，但不影響 NF-κB[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

阿奇霉素 (50 mg/kg) 對(duì)哮喘發(fā)作小鼠模型中的支氣管肺泡灌洗炎癥參數(shù)和 LDH 水平?jīng)]有影響。阿奇霉素不會(huì)在哮喘發(fā)作小鼠模型中誘導(dǎo)一般炎癥參數(shù)或 LDH 釋放，并且會(huì)增加哮喘發(fā)作小鼠中干擾素刺激基因和模式識(shí)別受體 MDA5 的表達(dá)，但不會(huì)增加 RIG-I 的表達(dá)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

748.98

Formula

C38H72N2O12
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

阿奇霉素；阿澤紅霉素；疊氮紅霉素；阿奇紅霉素
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : ≥ 100 mg/mL (133.51 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.3351 mL 6.6757 mL 13.3515 mL
5 mM 0.2670 mL 1.3351 mL 2.6703 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 方案 一

    請(qǐng)依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (3.34 mM); 澄清溶液

    此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請(qǐng)依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (3.34 mM); 懸濁液; 超聲助溶

    此方案可獲得 2.5 mg/mL的均勻懸濁液，懸濁液可用于口服和腹腔注射。

    以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

    2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購(gòu)。 ，Tween 80，均可在 MCE 網(wǎng)站選購(gòu)。
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
儲(chǔ)備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
您所需的儲(chǔ)備液濃度超過該產(chǎn)品的實(shí)測(cè)溶解度，以下方案僅供參考，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
連續(xù)給藥周期超過半月以上，請(qǐng)謹(jǐn)慎選擇該方案。
請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)
Cell Assay
[2]

THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3351 mL 6.6757 mL 13.3515 mL 33.3787 mL
5 mM 0.2670 mL 1.3351 mL 2.6703 mL 6.6757 mL
10 mM 0.1335 mL 0.6676 mL 1.3351 mL 3.3379 mL
15 mM 0.0890 mL 0.4450 mL 0.8901 mL 2.2252 mL
20 mM 0.0668 mL 0.3338 mL 0.6676 mL 1.6689 mL
25 mM 0.0534 mL 0.2670 mL 0.5341 mL 1.3351 mL
30 mM 0.0445 mL 0.2225 mL 0.4450 mL 1.1126 mL
40 mM 0.0334 mL 0.1669 mL 0.3338 mL 0.8345 mL
50 mM 0.0267 mL 0.1335 mL 0.2670 mL 0.6676 mL
60 mM 0.0223 mL 0.1113 mL 0.2225 mL 0.5563 mL
80 mM 0.0167 mL 0.0834 mL 0.1669 mL 0.4172 mL
100 mM 0.0134 mL 0.0668 mL 0.1335 mL 0.3338 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Azithromycin
目錄號(hào)：
HY-17506
需求量：