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  2. GPCR/G Protein
  3. CaSR
  4. Strontium Ranelate

Strontium Ranelate  (Synonyms: 雷尼酸鍶; Distrontium renelate; S12911)

目錄號: HY-17397 純度: 99.99%
COA 產品使用指南 技術支持

Strontium Ranelate (S12911) 是一種抗骨質疏松活性分子，其作用是通過減少骨吸收并促進骨形成，從而誘導正骨平衡。Strontium Ranelate 還可以激活非骨骼細胞中的鈣敏感受體 (CaSR)，從而導致肌醇 1、4、5-三磷酸生成和絲裂原活化的蛋白激酶信號轉導。

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Strontium Ranelate Chemical Structure

Strontium Ranelate Chemical Structure

CAS No. : 135459-87-9

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規(guī)格 價格 是否有貨 數(shù)量
100 mg ￥1000
In-stock
500 mg ￥3500
In-stock
1 g ￥5200
In-stock
5 g   詢價  
10 g   詢價  

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Other Forms of Strontium Ranelate:

MCE 顧客使用本產品發(fā)表的 2 篇科研文獻

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling[1][2].

體外研究
(In Vitro)

Strontium Ranelate (0.1-1 mM; 22 days; Mouse calvaria cells) treatment shows the expression of mRNA for early osteoblast markers (alkaline phosphatase, ALP) is visualized by day 5, while late markers (osteocalcin, OCN) are detectable only by day 15 and beyond[1].
Strontium Ranelate (0.1-1 mM; 22 days; Mouse calvaria cells) treatment results in significantly increases the mRNA expression of the osteoblastic markers ALP, BSP and OCN at day 22 of MC cell culture[1].
Strontium Ranelate is found to increase alkaline phosphatase activity and prostaglandin E2 production in a COX-2 dependent manner in murine marrow stromal cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Mouse calvaria (MC) cells
Concentration: 0.1 mM, 0.3 mM or 1 mM
Incubation Time: 22 days
Result: The expression of mRNA for early osteoblast markers (ALP) was visualized by day 5, while late markers (OCN) were detectable only by day 15 and beyond.

Western Blot Analysis[1]

Cell Line: Mouse calvaria (MC) cells
Concentration: 0.1 mM, 0.3 mM or 1 mM
Incubation Time: 22 days
Result: Significantly increased the mRNA expression of the osteoblastic markers ALP, BSP and OCN at day 22 of MC cell culture.
體內研究
(In Vivo)

Strontium Ranelate increases bone formation and decreased bone resorption, which results in increased bone mass in the vertebrae of intact adult mice[2].
In intact adult rats, Strontium Ranelate also increases bone mass, as measured by dual-energy X-ray absorptiometry, in lumbar vertebra and femur, and this is confirmed by histological assessment of trabecular bone volume in the tibial metaphysis[2].
Strontium Ranelate is found to decrease bone resorption and to increase bone formation in alveolar bone in normal adult monkeys (Macaca fascicularis), which exhibits extensive bone remodeling[2].
In ovariectomized rats, short-term (3 months) treatment with Strontium Ranelate prevents trabecular bone loss induced by oestrogen deficiency, as demonstrated by bone ash, bone mineral content and histomorphometric analysis in the tibial metaphysis. This effect results from decreased bone resorption while bone formation was maintained. These beneficial effects of Strontium Ranelate on bone mass and microarchitecture in ovariectomized rats are confirmed in long-term experiments. In this long-term study (2 years), the increase in bone mass and microarchitecture induced by Strontium Ranelate results in a marked improvement in bone strength, supporting the beneficial effect of this drug on bone resistance[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

513.49

Formula

C12H6N2O8SSr2
CAS 號
性狀

固體

顏色

Light yellow to yellow

中文名稱

雷尼酸鍶
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*該產品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

溶解性數(shù)據(jù)
細胞實驗： 

0.1 M HCL 中的溶解度 : 17.5 mg/mL (34.08 mM; 超聲助溶; 酸性條件溶解 (HCL 調節(jié)，pH≈3))

H2O 中的溶解度 : 2 mg/mL (3.89 mM; 超聲助溶 (<60°C))

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 1.9475 mL 9.7373 mL 19.4746 mL
5 mM 0.3895 mL 1.9475 mL 3.8949 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑： Saline

    Solubility: 2 mg/mL (3.89 mM); 澄清溶液; 超聲助溶 (<60°C)

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
您所需的儲備液濃度超過該產品的實測溶解度，如有需要，請與 MCE 中國技術支持聯(lián)系。
純度 & 產品資料
參考文獻

Strontium Ranelate 相關分類

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
H2O / 0.1 M HCL 1 mM 1.9475 mL 9.7373 mL 19.4746 mL 48.6864 mL
0.1 M HCL 5 mM 0.3895 mL 1.9475 mL 3.8949 mL 9.7373 mL
10 mM 0.1947 mL 0.9737 mL 1.9475 mL 4.8686 mL
15 mM 0.1298 mL 0.6492 mL 1.2983 mL 3.2458 mL
20 mM 0.0974 mL 0.4869 mL 0.9737 mL 2.4343 mL
25 mM 0.0779 mL 0.3895 mL 0.7790 mL 1.9475 mL
30 mM 0.0649 mL 0.3246 mL 0.6492 mL 1.6229 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Strontium Ranelate
目錄號：
HY-17397
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