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  4. SBE-β-CD

SBE-β-CD  (Synonyms: 磺丁基-β-環(huán)糊精; Sulfobutylether-β-Cyclodextrin)

目錄號: HY-17031 純度: 99.89%
COA 產(chǎn)品使用指南 技術(shù)支持

SBE-β-CD 是磺基丁基醚 β-cyclodextrin 衍生物，其用作賦形劑或助溶劑以增加難溶性活性分子的溶解度。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個人用途提供產(chǎn)品和服務(wù)

SBE-β-CD Chemical Structure

SBE-β-CD Chemical Structure

CAS No. : 182410-00-0

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3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
500 mg ￥500
In-stock
1 g ￥800
In-stock
5 g ￥1600
In-stock
10 g ￥2400
In-stock
25 g ￥4800
In-stock
50 g 現(xiàn)貨 詢價
> 100 g   詢價  

* Please select Quantity before adding items.

Customer Review

MCE 顧客使用本產(chǎn)品發(fā)表的 96 篇科研文獻(xiàn)

  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents[1].

體外研究
(In Vitro)

SBE-β-CD 是一種化學(xué)修飾的β-CD，是一種在水性介質(zhì)中帶負(fù)電荷的環(huán)狀親水性低聚糖。β-CD 功能僅在低濃度下是一種增溶劑，而 SBE7-β-CD 在較寬的濃度范圍內(nèi)表現(xiàn)出很強(qiáng)的增溶作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

20% SBE-β-CD 生理鹽水：
指南 (以下是我們推薦的方案。此方案僅提供指南，應(yīng)根據(jù)您的具體需要進(jìn)行修改)。
1. 將0.9 g NaCl 溶于100 mL 蒸餾水中，制成澄清的0.9% 鹽水溶液。
2. 量取 2 g 干燥的 SBE-β-CD。
3. 將 2 g SBE-β-CD 溶解在 0.9% 鹽水中，制成 10 mL 濃度為 20% (w/v) 的溶液.這些可能需要超聲波 (20-40 kHz，30 秒，重復(fù) 3 次) 或加熱 (37°C 約 30 分鐘)。如果觀察到沉淀，可通過加熱至 37°C 并在使用前渦旋來溶解沉淀。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2083-2257

CAS 號
性狀

固體

顏色

White to off-white

中文名稱

磺丁基-β-環(huán)糊精；磺丁基醚-β-環(huán)糊精
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture and light
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

H2O 中的溶解度 : ≥ 100 mg/mL

* "≥" means soluble, but saturation unknown.

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計(jì)算器
請輸入動物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實(shí)測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實(shí)測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.89%

參考文獻(xiàn)
Animal Administration
[2]

Rats[2]
A 300 g rat is administered with 1 mL of a 0.1 M SBE-β-CD solution containing 5.64 mg of Compound 1, and assuming an extracellular volume of 90 mL, less than 0.1% of the complex would rapidly dissociate due to the initial effects of dilution. This calculation, combined with the changing blood to plasma ratio in the presence of SBE-β-CD, provides a reasonable explanation for the observed differences in the blood and plasma profiles of Compound 1 after intravenous administration in either the cyclodextrin or cyclodextrin-free formulations. After IV administration of the cyclodextrin formulation, Compound 1 would initially be prevented from distributing into erythrocytes thereby resulting in a whole blood to plasma ratio of less than one. Subsequently, clearance of SBE-β-CD from the circulation would lead to changes in the complexation equilibrium such that the unbound fraction of Compound 1 would increase, thereby reestablishing normal blood to plasma partitioning (i.e. in favour of whole blood) and clearance.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
SBE-β-CD
目錄號：
HY-17031
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