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  2. Anti-infection
  3. Influenza Virus
  4. Oseltamivir phosphate

Oseltamivir phosphate  (Synonyms: 磷酸奧司他韋; GS 4104 phosphate)

目錄號: HY-17016 純度: 99.91%
COA 產(chǎn)品使用指南 技術(shù)支持

Oseltamivir phosphate (GS 4104) 是一種神經(jīng)氨酸酶 (neuraminidase) 抑制劑，用于流感 (influenza A 和 B) 的研究。

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Oseltamivir phosphate Chemical Structure

Oseltamivir phosphate Chemical Structure

CAS No. : 204255-11-8

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥500
In-stock
100 mg ￥380
In-stock
500 mg ￥1350
In-stock
1 g   詢價  
5 g   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Oseltamivir phosphate:

MCE 顧客使用本產(chǎn)品發(fā)表的 31 篇科研文獻(xiàn)

WB

    Oseltamivir phosphate purchased from MCE. Usage Cited in: Lab Invest. 2020 Dec;100(12):1602-1617.  [Abstract]

    After the HBc-positive cells are treated with OP (Oseltamivir phosphate), the phosphorylation of ERK and P65 significantly declined, the expression of IkBα increased, and the expression of nuclear P65 decreased.

    • 生物活性

    • 實(shí)驗參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.

    IC50 & Target

    Influenza A and B[1]
    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    MDCK CC50
    > 100 μM
    Compound: OSV-p
    Cytotoxicity against dog MDCK cells assessed as reduction in cell viability measured after 40 hrs by Celltiter-Glo assay
    Cytotoxicity against dog MDCK cells assessed as reduction in cell viability measured after 40 hrs by Celltiter-Glo assay
    		[PMID: 31425909]
    MDCK CC50
    > 100 μM
    Compound: OSV-p
    Cytotoxicity against MDCK cells assessed as reduction in cell viability by CellTiter-Glo assay
    Cytotoxicity against MDCK cells assessed as reduction in cell viability by CellTiter-Glo assay
    		[PMID: 34795865]
    MDCK CC50
    > 100 μM
    Compound: OSV-p
    Cytotoxicity against dog MDCK cells assessed as cell viability measured after 45 hrs by Celltiter-Glo luminescence assay
    Cytotoxicity against dog MDCK cells assessed as cell viability measured after 45 hrs by Celltiter-Glo luminescence assay
    		[PMID: 31635892]
    MDCK CC50
    > 163.26 μM
    Compound: Oseltamivir phosphate
    Cytotoxicity against MDCK cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against MDCK cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 31559005]
    MDCK CC50
    > 200 μM
    Compound: OSV-P
    Cytotoxicity against MDCK cells after 40 hrs incubation by CellTiter-Glo assay
    Cytotoxicity against MDCK cells after 40 hrs incubation by CellTiter-Glo assay
    		[PMID: 26866456]
    MDCK IC50
    > 500 μM
    Compound: Oseltamivir, Tamiflu
    Antiinfluenza activity against influenza B virus infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs
    Antiinfluenza activity against influenza B virus infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs
    		[PMID: 22341943]
    MDCK IC50
    1.1 μM
    Compound: Oseltamivir, Tamiflu
    Antiinfluenza activity against influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs
    Antiinfluenza activity against influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs
    		[PMID: 22341943]
    MDCK IC50
    15.5 μM
    Compound: Oseltamivir, Tamiflu
    Antiinfluenza activity against influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs
    Antiinfluenza activity against influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs
    		[PMID: 22341943]
    MDCK IC50
    45.6 μM
    Compound: Osv-p, Tamiflu
    Antiviral activity against Influenza A virus A/WSN/33 (H1N1) infected in MDCK cells assessed as inhibition of virus-induced cell death after 36 hrs by CellTiter-Glo luminescent cell viability assay
    Antiviral activity against Influenza A virus A/WSN/33 (H1N1) infected in MDCK cells assessed as inhibition of virus-induced cell death after 36 hrs by CellTiter-Glo luminescent cell viability assay
    		[PMID: 24957203]
    MDCK IC50
    45.6 μM
    Compound: Osv-P; Tamiflu
    Antiviral activity against Influenza A virus A/WSN/33(H1N1) infected in dog MDCK cells preincubated with virus for 15 mins followed by cells addition measured at 36 hrs post infection
    Antiviral activity against Influenza A virus A/WSN/33(H1N1) infected in dog MDCK cells preincubated with virus for 15 mins followed by cells addition measured at 36 hrs post infection
    		[PMID: 26841168]
    體外研究
    (In Vitro)

    Oseltamivir phosphate (OP) is a prodrug that is readily absorbed from the gastrointestinal tract after oral administration and is extensively converted predominantly by hepatic esterases to Oseltamivir carboxylate (OC)[1]. Oseltamivir phosphate is a widely used anti-influenza sialidase inhibitor. The metabolic activity of CMA07 and CMT-U27 cell lines is significantly decreased with 305 μM Oseltamivir phosphate treatment (p=0.005 and p<0.0001 respectively) using One Way ANOVA testes. In contrast, no statistically significant alterations are observed with 0.305 μM (p=0.9781), 3.05 μM (p=0.7436) and 30.5 μM (p=0.9623) of Oseltamivir phosphate treatments when compare with control cells. Finally, to assess the effect of Oseltamivir phosphate on CMA07 and CMT-U27 programmed cell death, and given that 305 μM Oseltamivir phosphate treatment impaired cell metabolic activity, a programmed cell death measurement is performed with the TUNEL assay. Twenty-four hour Oseltamivir phosphate treatment, specifically at 305 μM, significantly increases CMA07 (p=0.001) and CMT-U27 (p=0.0002) DNA fragmentation, suggesting promotion of programmed cell death, when compare with lower Oseltamivir concentrations, or with PBS[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Oseltamivir phosphate-treated mice present significantly more inflammatory infiltrate in primary tumors (p=0.01). Ki-67 antigen and caspase-3 protein are used to assess CMT-U27 xenograft tumor cell proliferation and apoptosis respectively. Virtually no differences are found in Ki-67 and caspase 3 (p=0.2) expression between Oseltamivir-treated and non-treated mice[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    410.40

    Formula

    C16H31N2O8P
    CAS 號
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    磷酸奧司他韋
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗： 

    H2O 中的溶解度 : 100 mg/mL (243.66 mM; 超聲助溶)

    DMSO 中的溶解度 : 100 mg/mL (243.66 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 2.4366 mL 12.1832 mL 24.3665 mL
    5 mM 0.4873 mL 2.4366 mL 4.8733 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

    * 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實(shí)驗：

    請根據(jù)您的 實(shí)驗動物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

    以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
    ——為保證實(shí)驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (6.09 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

      生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
    • 方案 二

      請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (6.09 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

      2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
    動物溶解方案計算器
    請輸入動物實(shí)驗的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實(shí)驗過程有損耗，建議您多配一只動物的量
    計算結(jié)果
    工作液所需濃度 : mg/mL
    該產(chǎn)品水溶性佳，請具體參考實(shí)測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
    您所需的儲備液濃度超過該產(chǎn)品的實(shí)測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
    純度 & 產(chǎn)品資料

    純度: 99.91%

    參考文獻(xiàn)
    Cell Assay
    [2]

    CMA07 and CMT-U27 cells are cultured in 24-well plates in triplicate for each condition: 0.305 μM, 3.05 μM, 30.5 μM and 305 μM Oseltamivir phosphate and PBS is used as control. Cells are counted every day for 7 days in a Neubauer’s chamber in a 1:2 dilution of cells in 0.4% trypan blue and cell count is done using the volume conversion factor for 1 mm3, which is 1×104. This assay is repeated 3 times and growth curves are traced[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [2]

    Mice[2]
    Female NIH(S)II-nu/nu nude mice, aged 4-6 weeks, are orthotopically inoculated with 1×106 viable CMT-U27 canine breast cancer cells in the mammary fat pad using a 25 gauge needle. A total of 8 mice are inoculated. When nodules reached a volume of approximately 500 mm3, mice (n=8) are randomized and divided into control group (n=4) and treatment group (n=4).The animals receive intraperitoneally (IP) dailly either 100 μL of PBS (control group) or 100mg/Kg of Oseltamivir phosphate, diluted in PBS (treatment group) until time of death. Tumor size is measured using calipers, and tumor volume (mm3) is estimated by width×length×height.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    參考文獻(xiàn)

    Oseltamivir phosphate 相關(guān)分類

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.4366 mL 12.1832 mL 24.3665 mL 60.9162 mL
    5 mM 0.4873 mL 2.4366 mL 4.8733 mL 12.1832 mL
    10 mM 0.2437 mL 1.2183 mL 2.4366 mL 6.0916 mL
    15 mM 0.1624 mL 0.8122 mL 1.6244 mL 4.0611 mL
    20 mM 0.1218 mL 0.6092 mL 1.2183 mL 3.0458 mL
    25 mM 0.0975 mL 0.4873 mL 0.9747 mL 2.4366 mL
    30 mM 0.0812 mL 0.4061 mL 0.8122 mL 2.0305 mL
    40 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.5229 mL
    50 mM 0.0487 mL 0.2437 mL 0.4873 mL 1.2183 mL
    60 mM 0.0406 mL 0.2031 mL 0.4061 mL 1.0153 mL
    80 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.7615 mL
    100 mM 0.0244 mL 0.1218 mL 0.2437 mL 0.6092 mL

    * 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

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    產(chǎn)品名稱：
    Oseltamivir phosphate
    目錄號：
    HY-17016
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