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  2. Cell Cycle/DNA Damage Cytoskeleton Antibody-drug Conjugate/ADC Related
  3. Microtubule/Tubulin ADC Cytotoxin
  4. MMAD

MMAD  (Synonyms: Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10)

目錄號: HY-15581 純度: 99.66%
COA 產(chǎn)品使用指南 技術(shù)支持

MMAD 是一種有效的微管 (tubulin) 抑制劑，是抗體活性分子偶聯(lián)物 (ADCs) 中的活性分子。

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MMAD Chemical Structure

MMAD Chemical Structure

CAS No. : 203849-91-6

1.  客戶無需承擔相應的運輸費用。

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     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

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規(guī)格 價格 是否有貨 數(shù)量
Free Sample (0.1 - 0.2 mg)   Apply now  
5 mg ￥640
In-stock
10 mg ￥1120
In-stock
50 mg ￥3120
In-stock
100 mg ￥5000
In-stock
200 mg   詢價  
500 mg   詢價  

* Please select Quantity before adding items.

Other Forms of MMAD:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs).

IC50 & Target

Auristatin

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
BT-474 GI50
0.12 nM
Compound: 2, MMAD
Cytotoxicity against human BT474 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human BT474 cells assessed as cell viability incubated fore 4 days by MTS assay
[PMID: 25431858]
MDA-MB-361 GI50
0.09 nM
Compound: 2, MMAD
Cytotoxicity against human MDA-MB-361 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human MDA-MB-361 cells assessed as cell viability incubated fore 4 days by MTS assay
[PMID: 25431858]
NCI-N87 GI50
0.3 nM
Compound: 2, MMAD
Cytotoxicity against human NCI-N87 cells assessed as cell viability incubated fore 4 days by MTS assay
Cytotoxicity against human NCI-N87 cells assessed as cell viability incubated fore 4 days by MTS assay
[PMID: 25431858]
體外研究
(In Vitro)

MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

771.06

Formula

C41H66N6O6S
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, stored under nitrogen

*該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : ≥ 100 mg/mL (129.69 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.2969 mL 6.4846 mL 12.9692 mL
5 mM 0.2594 mL 1.2969 mL 2.5938 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)用現(xiàn)配，即刻使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2969 mL 6.4846 mL 12.9692 mL 32.4229 mL
5 mM 0.2594 mL 1.2969 mL 2.5938 mL 6.4846 mL
10 mM 0.1297 mL 0.6485 mL 1.2969 mL 3.2423 mL
15 mM 0.0865 mL 0.4323 mL 0.8646 mL 2.1615 mL
20 mM 0.0648 mL 0.3242 mL 0.6485 mL 1.6211 mL
25 mM 0.0519 mL 0.2594 mL 0.5188 mL 1.2969 mL
30 mM 0.0432 mL 0.2162 mL 0.4323 mL 1.0808 mL
40 mM 0.0324 mL 0.1621 mL 0.3242 mL 0.8106 mL
50 mM 0.0259 mL 0.1297 mL 0.2594 mL 0.6485 mL
60 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.5404 mL
80 mM 0.0162 mL 0.0811 mL 0.1621 mL 0.4053 mL
100 mM 0.0130 mL 0.0648 mL 0.1297 mL 0.3242 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
MMAD
目錄號：
HY-15581
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