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  2. MAPK/ERK Pathway
  3. Ribosomal S6 Kinase (RSK)
  4. SL 0101-1

SL 0101-1 (SL0101) 是從熱帶植物F. refracta 中提取得到的山萘酚糖苷，是能穿透細(xì)胞的、選擇性的、可逆的、ATP競爭性的 p90核糖體S6激酶(RSK) 的抑制劑，其IC50 值為 89 nM。SL 0101-1 (SL0101) 是選擇性的 RSK1/2 抑制劑，其 Ki 值為 1 μM。

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SL 0101-1 Chemical Structure

SL 0101-1 Chemical Structure

CAS No. : 77307-50-7

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥6704
In-stock
1 mg ￥1900
In-stock
5 mg ￥5900
In-stock
10 mg   詢價  
50 mg   詢價  

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Customer Review

查看 Ribosomal S6 Kinase (RSK) 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a Ki of 1 μM[2].

IC50 & Target

RSK1

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCC70 IC50
15 μM
Compound: 52; SL0101
Anticancer activity against human HCC70 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
Anticancer activity against human HCC70 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
[PMID: 33650861]
MCF7 IC50
45.6 μM
Compound: 1, SL0101
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-GloTM assay
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-GloTM assay
[PMID: 22464132]
MDA-MB-231 IC50
3 μM
Compound: 52; SL0101
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
[PMID: 33650861]
Sf9 IC50
0.583 μM
Compound: 1, SL0101
Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay
Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay
[PMID: 22464132]
Sf9 IC50
0.99 μM
Compound: 1, SL0101
Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using GST-fusion protein containing ERalpha-Ser167 sequence-RLASTND as substrate by chemiluminescence analysis
Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using GST-fusion protein containing ERalpha-Ser167 sequence-RLASTND as substrate by chemiluminescence analysis
[PMID: 23519677]
Sf9 IC50
89 nM
Compound: SL0101
Inhibition of his-tagged active RSK2 (unknown origin) expressed in Sf9 cells after 10 to 45 mins by ELISA
Inhibition of his-tagged active RSK2 (unknown origin) expressed in Sf9 cells after 10 to 45 mins by ELISA
[PMID: 25147152]
體外研究
(In Vitro)

SL 0101-1 (SL0101) 在人乳腺癌細(xì)胞系 MCF-7 中表現(xiàn)出增殖抑制作用，并在 G1 期[1] 產(chǎn)生細(xì)胞周期阻滯。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

516.45

Formula

C25H24O12
CAS 號
性狀

固體

顏色

White to yellow

結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實驗： 

DMSO 中的溶解度 : 10 mg/mL (19.36 mM; 超聲加熱助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.9363 mL 9.6815 mL 19.3630 mL
5 mM 0.3873 mL 1.9363 mL 3.8726 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9363 mL 9.6815 mL 19.3630 mL 48.4074 mL
5 mM 0.3873 mL 1.9363 mL 3.8726 mL 9.6815 mL
10 mM 0.1936 mL 0.9681 mL 1.9363 mL 4.8407 mL
15 mM 0.1291 mL 0.6454 mL 1.2909 mL 3.2272 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
SL 0101-1
目錄號：
HY-15237
需求量：