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  2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. EB-47

EB-47 是一種有效的 PARP-1/ARTD-1 選擇性抑制劑，IC50 值為 45 nM，對 ARTD5 的IC50 值為 410 nM，表現(xiàn)出溫和的藥效。EB-47 模擬底物 NAD+，從煙酰胺延伸至腺苷亞區(qū)結(jié)合。

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EB-47 Chemical Structure

EB-47 Chemical Structure

CAS No. : 366454-36-6

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥985
1 - 2 周
5 mg   詢價  
10 mg   詢價  

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Customer Review

Other Forms of EB-47:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+?and extends from the nicotinamide to the adenosine subsite[1].

IC50 & Target[1]

ARTD1/PARP1

45 nM (IC50)

體外研究
(In Vitro)

EB-47 shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC50 values of 0.86 and 1.0?μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

EB-47 (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

537.53

Formula

C24H27N9O6
CAS 號
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
EB-47
目錄號：
HY-15046
需求量：