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  2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Verubulin

Verubulin  (Synonyms: MPC 6827)

目錄號: HY-14907 純度: 99.34%
COA 產(chǎn)品使用指南

Verubulin (MPC-6827) 是一種高效、廣譜的微管阻斷劑，具有體內(nèi)外細(xì)胞毒活性，有前景成為多種癌癥的潛在候選藥物。

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Verubulin Chemical Structure

Verubulin Chemical Structure

CAS No. : 827031-83-4

1.  客戶無需承擔(dān)相應(yīng)的運(yùn)輸費用。

2.  同一機(jī)構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機(jī)構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥880
In-stock
5 mg ￥800
In-stock
10 mg ￥1350
In-stock
50 mg ￥4750
In-stock
100 mg 現(xiàn)貨 詢價
200 mg   詢價  
500 mg   詢價  

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Customer Review

Other Forms of Verubulin:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Verubulin (MPC-6827) is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities, and acts as a promising candidate for the treatment of multiple cancer types[1].

IC50 & Target

Microtubule[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
0.7 nM
Compound: Verubulin
Antiproliferative activity against human A-375 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
Antiproliferative activity against human A-375 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
[PMID: 34406768]
A375/TxR IC50
0.7 nM
Compound: Verubulin
Antiproliferative activity against human A375/TxR cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
Antiproliferative activity against human A375/TxR cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
[PMID: 34406768]
A-431 IC50
0.9 nM
Compound: 1
Cytotoxicity against human A-431 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human A-431 cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
A549 IC50
0.003 μM
Compound: EP128495
Growth inhibition of human A549 cells after 48 hrs by MTT assay
Growth inhibition of human A549 cells after 48 hrs by MTT assay
[PMID: 29509413]
A549 IC50
0.004 μM
Compound: MPC-6827
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 48 hrs by MTT assay
[PMID: 29673981]
A549 IC50
0.005 μM
Compound: MPC6827
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 30093295]
A549/CDDP IC50
0.009 μM
Compound: EP128495
Growth inhibition of human A549/CDDP cells after 48 hrs by MTT assay
Growth inhibition of human A549/CDDP cells after 48 hrs by MTT assay
[PMID: 29509413]
BJ IC50
0.015 μM
Compound: EP128495
Antiproliferative activity against human BJ cells after 48 hrs by MTT assay
Antiproliferative activity against human BJ cells after 48 hrs by MTT assay
[PMID: 29509413]
HCT-116 EC50
0.003 μM
Compound: 6h, EP128495,MPC-6827, azixa
Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
[PMID: 19296653]
HCT-116 IC50
0.004 μM
Compound: EP128495
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay
[PMID: 29509413]
HCT-116 IC50
0.005 μM
Compound: MPC-6827
Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells incubated for 48 hrs by MTT assay
[PMID: 29673981]
HCT-116 GI50
0.006 μM
Compound: 6h, EP128495,MPC-6827, azixa
Growth inhibition of human HCT116 cells after 48 hrs by celltiter assay
Growth inhibition of human HCT116 cells after 48 hrs by celltiter assay
[PMID: 19296653]
HCT-116 IC50
0.009 μM
Compound: MPC6827
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 30093295]
HCT-116 IC50
4.3 nM
Compound: 5; MPC-6827
Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay
[PMID: 27213819]
HeLa IC50
0.005 μM
Compound: EP128495
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 29509413]
HeLa IC50
0.006 μM
Compound: MPC-6827
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay
[PMID: 29673981]
HeLa IC50
0.007 μM
Compound: MPC6827
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 30093295]
HeLa IC50
1.5 nM
Compound: 1
Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human HeLa cells over expressing WT-beta3 assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
HeLa IC50
2 nM
Compound: 1
Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
HepG2 IC50
0.005 μM
Compound: MPC-6827
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
[PMID: 29673981]
HepG2 IC50
0.005 μM
Compound: EP128495
Growth inhibition of human HepG2 cells after 48 hrs by MTT assay
Growth inhibition of human HepG2 cells after 48 hrs by MTT assay
[PMID: 29509413]
HepG2 IC50
0.006 μM
Compound: MPC6827
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 30093295]
HepG2 IC50
4.6 nM
Compound: 5; MPC-6827
Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay
[PMID: 27213819]
L02 IC50
0.013 μM
Compound: EP128495
Antiproliferative activity against human LO2 cells after 48 hrs by MTT assay
Antiproliferative activity against human LO2 cells after 48 hrs by MTT assay
[PMID: 29509413]
LoVo IC50
0.008 μM
Compound: EP128495
Growth inhibition of human LoVo cells after 48 hrs by MTT assay
Growth inhibition of human LoVo cells after 48 hrs by MTT assay
[PMID: 29509413]
M14 IC50
1 nM
Compound: Verubulin
Antiproliferative activity against human M14 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
Antiproliferative activity against human M14 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
[PMID: 34406768]
MCF7 IC50
0.011 μM
Compound: EP128495
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 29509413]
MDA-MB-231 IC50
0.008 μM
Compound: MPC-6827
Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
[PMID: 29673981]
MDA-MB-231 IC50
0.008 μM
Compound: EP128495
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
Growth inhibition of human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 29509413]
MDA-MB-435 IC50
1.7 nM
Compound: 1
Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay
Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
MGC-803 IC50
0.008 μM
Compound: EP128495
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
[PMID: 29509413]
NCI-H1299 EC50
0.006 μM
Compound: 1e
Induction of apoptosis in human H1299 cells assessed as caspase activation after 48 hrs by HTS assay
Induction of apoptosis in human H1299 cells assessed as caspase activation after 48 hrs by HTS assay
[PMID: 19464890]
RKO IC50
0.003 μM
Compound: EP128495
Growth inhibition of human RKO cells after 48 hrs by MTT assay
Growth inhibition of human RKO cells after 48 hrs by MTT assay
[PMID: 29509413]
RKO IC50
0.005 μM
Compound: MPC6827
Antiproliferative activity against human RKO cells after 48 hrs by MTT assay
Antiproliferative activity against human RKO cells after 48 hrs by MTT assay
[PMID: 30093295]
SK-OV-3 IC50
2.2 nM
Compound: 1
Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
SK-OV-3 IC50
2.6 nM
Compound: 1
Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human SK-OV-3 cells over expressing MDR1-6/6 assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
SK-OV-3 IC50
3.2 nM
Compound: 5; MPC-6827
Antiproliferative activity against human SKOV3 cells after 24 hrs by MTT assay
Antiproliferative activity against human SKOV3 cells after 24 hrs by MTT assay
[PMID: 27213819]
SNU-398 EC50
0.002 μM
Compound: 6h, EP128495,MPC-6827, azixa
Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay
Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay
[PMID: 19296653]
SNU-398 GI50
0.003 μM
Compound: 6h, EP128495,MPC-6827, azixa
Growth inhibition of human SNU398 cells after 48 hrs by celltiter assay
Growth inhibition of human SNU398 cells after 48 hrs by celltiter assay
[PMID: 19296653]
T47D EC50
0.002 μM
Compound: 6h, EP128495,MPC-6827, azixa
Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
[PMID: 19296653]
T47D EC50
0.002 μM
Compound: 1e
Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs by HTS assay
Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs by HTS assay
[PMID: 19464890]
T47D GI50
0.006 μM
Compound: 6h, EP128495,MPC-6827, azixa
Growth inhibition of human T47D cells after 48 hrs by celltiter assay
Growth inhibition of human T47D cells after 48 hrs by celltiter assay
[PMID: 19296653]
U-251 IC50
2.8 nM
Compound: 1
Cytotoxicity against human U-251 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human U-251 cells assessed as reduction in cell viability by Sulforhodamine B assay
[PMID: 33647840]
Clinical Trial
分子量

279.34

Formula

C17H17N3O
CAS 號
性狀

固體

顏色

Light yellow to yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (357.99 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.5799 mL 17.8993 mL 35.7987 mL
5 mM 0.7160 mL 3.5799 mL 7.1597 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

請根據(jù)您的 實驗動物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 方案 一

    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (7.45 mM); 澄清溶液

    此方案可獲得 ≥ 2.08 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 20.8 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (7.45 mM); 澄清溶液

    此方案可獲得 ≥ 2.08 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 20.8 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

    2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
請輸入您的動物體內(nèi)配方組成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購。 ，Tween 80，均可在 MCE 網(wǎng)站選購。
計算結(jié)果
工作液所需濃度 : mg/mL
儲備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
動物實驗體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
連續(xù)給藥周期超過半月以上，請謹(jǐn)慎選擇該方案。
請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5799 mL 17.8993 mL 35.7987 mL 89.4967 mL
5 mM 0.7160 mL 3.5799 mL 7.1597 mL 17.8993 mL
10 mM 0.3580 mL 1.7899 mL 3.5799 mL 8.9497 mL
15 mM 0.2387 mL 1.1933 mL 2.3866 mL 5.9664 mL
20 mM 0.1790 mL 0.8950 mL 1.7899 mL 4.4748 mL
25 mM 0.1432 mL 0.7160 mL 1.4319 mL 3.5799 mL
30 mM 0.1193 mL 0.5966 mL 1.1933 mL 2.9832 mL
40 mM 0.0895 mL 0.4475 mL 0.8950 mL 2.2374 mL
50 mM 0.0716 mL 0.3580 mL 0.7160 mL 1.7899 mL
60 mM 0.0597 mL 0.2983 mL 0.5966 mL 1.4916 mL
80 mM 0.0447 mL 0.2237 mL 0.4475 mL 1.1187 mL
100 mM 0.0358 mL 0.1790 mL 0.3580 mL 0.8950 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Verubulin
目錄號：
HY-14907
需求量：