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  2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Zinterol

Zinterol  (Synonyms: 凈特羅; MJ 9184)

目錄號(hào): HY-14304
產(chǎn)品使用指南

Zinterol (MJ 9184) 是一種有效的選擇性 β2-腎上腺素受體 (β2-adrenoceptor) 激動(dòng)劑。Zinterol 增強(qiáng) ICa，EC50 為 2.2 nM。

在相同的摩爾濃度下，化合物鹽形式與游離形式有相同的生物活性，但鹽形式 Zinterol hydrochloride 通常具有更好的水溶性和穩(wěn)定性。

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Zinterol Chemical Structure

Zinterol Chemical Structure

CAS No. : 37000-20-7

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Zinterol 的其他形式現(xiàn)貨產(chǎn)品:

Customer Review

Other Forms of Zinterol:

查看 Adrenergic Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2].

IC50 & Target

β adrenergic receptor

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
0.054 nM
Compound: Zinterol
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
[PMID: 20804199]
體內(nèi)研究
(In Vivo)

Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: In New Zealand White HF rabbits of either sex[3]
Dosage: 1.0 or 2.5 μg/kg
Administration: Intravenous bolus administration; over 5 seconds
Result: 2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits.
分子量

378.49

Formula

C19H26N2O4S
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

凈特羅
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Zinterol
目錄號(hào)：
HY-14304
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