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  2. Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Hexokinase HSV Apoptosis
  4. 2-Deoxy-D-glucose

2-Deoxy-D-glucose  (Synonyms: 2-脫氧-D-葡萄糖; 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose)

目錄號: HY-13966 純度: 99.93%
COA 產(chǎn)品使用指南 技術(shù)支持

2-Deoxy-D-glucose 是一種葡萄糖類似物，為葡萄糖代謝抑制劑，通過作用于己糖激酶 (hexokinase) 來抑制糖酵解 (glycolysis)。

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2-Deoxy-D-glucose Chemical Structure

2-Deoxy-D-glucose Chemical Structure

CAS No. : 154-17-6

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規(guī)格 價格 是否有貨 數(shù)量
500 mg ￥400
In-stock
1 g ￥500
In-stock
5 g ￥1488
In-stock
10 g ￥2550
In-stock
50 g   詢價  

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Customer Review

Other Forms of 2-Deoxy-D-glucose:

MCE 顧客使用本產(chǎn)品發(fā)表的 186 篇科研文獻

WB

    2-Deoxy-D-glucose purchased from MCE. Usage Cited in: Ann N Y Acad Sci. 2023 Mar 18.  [Abstract]

    2-Deoxy-D-glucose (2-DG; 200 μM) reduces the protein levels of CASP11, cleaved-CASP11, NLRP3, GSDMD-FL, and GSDMD-NT, accompanied by effective inhibition of the markers involved in glycolysis, in OCCM-30 cells.

    2-Deoxy-D-glucose purchased from MCE. Usage Cited in: Oncotarget. 2017 Jul 4;8(27):44669-44681.  [Abstract]

    Effect of 2-DG treatment on BRSK2 and other components of AKT/mTOR signaling pathway. PANC-1 cells are treated with series concentrations of 2-DG for three hours before analysis.

    查看 HSV 亞型特異性產(chǎn)品:

    • 生物活性

    • 實驗參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻

    生物活性

    2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1].

    IC50 & Target[1]

    HSV-1

     

    體外研究
    (In Vitro)

    2-Deoxy-D-glucose (2-DG、4、8 或 16 mM) 以劑量和時間依賴性方式顯著降低 MCF-7 細胞中的 ATP 水平，這與 2-DG 對細胞的作用相似生長。在暴露于 4、8 或 16 mM 2-Deoxy-D-glucose 1、3 或以劑量和時間依賴性方式持續(xù) 5 天[1]。2-DG 處理可增加磷酸戊糖途徑 (PPP) 代謝物的水平，并增加 6-磷酸葡萄糖脫氫酶產(chǎn)生的 NADPH。NADPH 的增加和谷胱甘肽合成酶表達的上調(diào)導(dǎo)致 NB4 細胞中 2-DG 還原形式的谷胱甘肽增加[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    2-Deoxy-D-glucose (0.03%，w/w) 導(dǎo)致最終體重降低 7%，這具有統(tǒng)計學(xué)意義，并延遲了可觸及的乳腺癌的出現(xiàn)[1]。2-Deoxy-D-glucose (3 mmol/kg，iv) 在大鼠肌肉中以劑量依賴性方式降低[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    164.16

    Formula

    C6H12O5
    CAS 號
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    2-脫氧-D-葡萄糖
    結(jié)構(gòu)分類
    初始來源
    運輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性數(shù)據(jù)
    細胞實驗： 

    H2O 中的溶解度 : ≥ 24 mg/mL (146.20 mM)

    * "≥" means soluble, but saturation unknown.

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 6.0916 mL 30.4581 mL 60.9162 mL
    5 mM 1.2183 mL 6.0916 mL 12.1832 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

    * 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實驗：

    以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

    • 方案 一

      請依序添加每種溶劑： PBS

      Solubility: 130 mg/mL (791.91 mM); 澄清溶液; 超聲助溶

    動物溶解方案計算器
    請輸入動物實驗的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實驗過程有損耗，建議您多配一只動物的量
    計算結(jié)果
    工作液所需濃度 : mg/mL
    該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
    您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
    純度 & 產(chǎn)品資料

    純度: 99.93%

    參考文獻
    Cell Assay
    [1]

    The effect of 2-DG on cell growth is determined by evaluating the number of adherent cells. Briefly, MCF-7 cells are plated at 3×104?cells per well in flat-bottomed 96-well plates in 100 μL of culture medium under the culture conditions. After 24 hours, cells are fed with fresh medium including 2-Deoxy-D-glucose at doses of 0, 4, 8, or 16 mM. At days 1, 3, and 5 after 2-Deoxy-D-glucose exposure, cells are fixed with 1% glutaraldehyde, replaced with PBS, and stored at 4°C. At the end of an experiment, all of the plates are stained with 0.02% aqueous crystal violet for 30 minutes and rinsed with deionized water. After redissolving the bound crystal violet in 70% ethanol, the absorbance is determined at 590 nm using a SPECTRA MAX PLUS Microplate Spectrophotometer System.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [1]

    At 21 days of age, rats are injected with 50 mg 1-methyl-1-nitrosourea per kilogram of body weight (i.p.). Rats are housed two per cage in solid-bottomed polycarbonate cages equipped with a food cup. Six days following carcinogen injection, all rats are randomized into one of three groups, 30 rats per group, and are fed?ad libitum?AIN-93G diet containing 0.0%, 0.02%, or 0.03% (w/w) 2-Deoxy-D-glucose (2-DG) for 5 weeks. Animal rooms are maintained at 22±1°C with 50% relative humidity and a 12-hour light/12-hour dark cycle. Rats are weighed thrice per week and are palpated for detection of mammary tumors twice per week starting from 19 days postcarcinogen.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    參考文獻

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 6.0916 mL 30.4581 mL 60.9162 mL 152.2904 mL
    5 mM 1.2183 mL 6.0916 mL 12.1832 mL 30.4581 mL
    10 mM 0.6092 mL 3.0458 mL 6.0916 mL 15.2290 mL
    15 mM 0.4061 mL 2.0305 mL 4.0611 mL 10.1527 mL
    20 mM 0.3046 mL 1.5229 mL 3.0458 mL 7.6145 mL
    25 mM 0.2437 mL 1.2183 mL 2.4366 mL 6.0916 mL
    30 mM 0.2031 mL 1.0153 mL 2.0305 mL 5.0763 mL
    40 mM 0.1523 mL 0.7615 mL 1.5229 mL 3.8073 mL
    50 mM 0.1218 mL 0.6092 mL 1.2183 mL 3.0458 mL
    60 mM 0.1015 mL 0.5076 mL 1.0153 mL 2.5382 mL
    80 mM 0.0761 mL 0.3807 mL 0.7615 mL 1.9036 mL
    100 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.5229 mL

    * 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

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    產(chǎn)品名稱：
    2-Deoxy-D-glucose
    目錄號：
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