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  2. Anti-infection Cell Cycle/DNA Damage
  3. Antibiotic Bacterial DNA/RNA Synthesis
  4. Sarecycline hydrochloride

Sarecycline hydrochloride  (Synonyms: P-005672 hydrochloride)

目錄號(hào): HY-13858A 純度: 98.01%
COA 產(chǎn)品使用指南 技術(shù)支持

Sarecycline hydrochloride 是一種口服有效的窄譜四環(huán)素衍生物類抗生素。Sarecycline hydrochloride 具有抗炎活性。Sarecycline hydrochloride 能夠抑制革蘭氏陽(yáng)性細(xì)菌和多種痤瘡角質(zhì)桿菌的活性。Sarecycline hydrochloride 干擾 tRNA 調(diào)節(jié)并將 mRNA 與 70S 核糖體結(jié)合。Sarecycline hydrochloride 能夠用于中重度痤瘡的研究 。

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Sarecycline hydrochloride Chemical Structure

Sarecycline hydrochloride Chemical Structure

CAS No. : 1035979-44-2

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥5994
In-stock
1 mg ￥1800
In-stock
5 mg ￥5200
In-stock
10 mg 現(xiàn)貨 詢價(jià)
25 mg 現(xiàn)貨 詢價(jià)
50 mg 現(xiàn)貨 詢價(jià)
100 mg 現(xiàn)貨 詢價(jià)
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

Other Forms of Sarecycline hydrochloride:

    Sarecycline hydrochloride purchased from MCE. Usage Cited in: Microbiol Spectr. 2022 Dec 8;e0323822.  [Abstract]

    The MIC distributions of Sarecycline against 43 M. fortuitum isolates. The y axis shows the number of strains with each MIC value, with the specific numbers shown above the bars.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne [1][2][3][4][5][6].

    IC50 & Target

    Tetracycline

     

    體外研究
    (In Vitro)

    Sarecycline hydrochloride 抑制 55 種 C. acnes 的臨床分離株。Sarecycline hydrochloride 的 MIC 值范圍為 0.5 至 16 μg/mL；MIC50為 0.5 μg/mL，MIC90 為 4 μg/mL。Sarecycline hydrochloride 對(duì)大環(huán)內(nèi)酯類耐藥菌具有活性[1]。
    Sarecycline hydrochloride 對(duì)腸道需氧革蘭氏陰性菌具有極小的活性[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Sarecycline hydrochloride (0.33-9 mg/kg；靜脈注射) 在小鼠中性粒細(xì)胞減少性大腿感染模型中顯示出對(duì)金黃色葡萄球菌的有效活性[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female SD-1 mice (A murine neutropenic thigh wound infection model)[1]
    Dosage: 0.33, 1, 3, or 9?mg/kg
    Administration: Intravenously
    Result: Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively.
    Animal Model: Carrageenan-induced footpad edema male Sprague Dawley rats model[6]
    Dosage: 1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg
    Administration: Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw.
    Result: Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.
    Clinical Trial
    分子量

    523.96

    Formula

    C24H30ClN3O8
    CAS 號(hào)
    性狀

    固體

    顏色

    Light yellow to yellow

    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 100 mg/mL (190.85 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 1.9085 mL 9.5427 mL 19.0854 mL
    5 mM 0.3817 mL 1.9085 mL 3.8171 mL
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物溶解方案計(jì)算器
    請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    純度 & 產(chǎn)品資料

    純度: 99.27%

    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.9085 mL 9.5427 mL 19.0854 mL 47.7136 mL
    5 mM 0.3817 mL 1.9085 mL 3.8171 mL 9.5427 mL
    10 mM 0.1909 mL 0.9543 mL 1.9085 mL 4.7714 mL
    15 mM 0.1272 mL 0.6362 mL 1.2724 mL 3.1809 mL
    20 mM 0.0954 mL 0.4771 mL 0.9543 mL 2.3857 mL
    25 mM 0.0763 mL 0.3817 mL 0.7634 mL 1.9085 mL
    30 mM 0.0636 mL 0.3181 mL 0.6362 mL 1.5905 mL
    40 mM 0.0477 mL 0.2386 mL 0.4771 mL 1.1928 mL
    50 mM 0.0382 mL 0.1909 mL 0.3817 mL 0.9543 mL
    60 mM 0.0318 mL 0.1590 mL 0.3181 mL 0.7952 mL
    80 mM 0.0239 mL 0.1193 mL 0.2386 mL 0.5964 mL
    100 mM 0.0191 mL 0.0954 mL 0.1909 mL 0.4771 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Inquiry Information

    產(chǎn)品名稱：
    Sarecycline hydrochloride
    目錄號(hào)：
    HY-13858A
    需求量：