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  2. Epigenetics
  3. Histone Demethylase
  4. JMJD7-IN-1

JMJD7-IN-1 是一種有效的 JMJD7 抑制劑，IC50 值為 6.62 μM。JMJD7-IN-1 對(duì)表達(dá)高水平 JMJD7 的細(xì)胞顯示出良好的抑制活性。

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JMJD7-IN-1 Chemical Structure

JMJD7-IN-1 Chemical Structure

CAS No. : 311316-96-8

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規(guī)格 價(jià)格 是否有貨 數(shù)量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥399
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5 mg ￥500
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10 mg ￥800
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25 mg ￥1700
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50 mg ￥2700
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100 mg ￥4300
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200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

查看 Histone Demethylase 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

JMJD7-IN-1 is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7[1].

IC50 & Target

IC50: 6.62 μM (JMJD7)[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
BJ IC50
> 100 μM
Compound: 3
Cytotoxicity against human BJ cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human BJ cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
HeLa IC50
16.14 μM
Compound: 3
Cytotoxicity against human HeLa cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
Jurkat IC50
15.03 μM
Compound: 3
Cytotoxicity against human Jurkat cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
SH-SY5Y IC50
> 100 μM
Compound: 3
Cytotoxicity against human SH-SY5Y cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
SK-BR-3 IC50
13.26 μM
Compound: 3
Cytotoxicity against human SK-BR-3 cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human SK-BR-3 cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
T47D IC50
9.4 μM
Compound: 3
Cytotoxicity against human T47D cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human T47D cells assessed as growth inhibition measured after 72 hrs by MTT assay
[PMID: 34048880]
體外研究
(In Vitro)

JMJD7-IN-1 (0.1-1000 μM) 劑量依賴性地抑制 JMJD7 的活性，IC50 為 6.62 μM[1]。
JMJD7 -IN-1 有效結(jié)合 JMJD7，IC50 為 3.80 μM[1]。
JMJD7-IN-1 (72 h) 抑制生長(zhǎng)T-47d、SK-BR-3、Jurkat 和 Hela 細(xì)胞，IC50 分別為 9.40 μM、13.26 μM、15.03 μM 和 16.14 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

363.15

Formula

C16H8Cl2N2O4
CAS 號(hào)
性狀

固體

顏色

White to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 8.33 mg/mL (22.94 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.7537 mL 13.7684 mL 27.5368 mL
5 mM 0.5507 mL 2.7537 mL 5.5074 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7537 mL 13.7684 mL 27.5368 mL 68.8421 mL
5 mM 0.5507 mL 2.7537 mL 5.5074 mL 13.7684 mL
10 mM 0.2754 mL 1.3768 mL 2.7537 mL 6.8842 mL
15 mM 0.1836 mL 0.9179 mL 1.8358 mL 4.5895 mL
20 mM 0.1377 mL 0.6884 mL 1.3768 mL 3.4421 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

產(chǎn)品名稱：
JMJD7-IN-1
目錄號(hào)：
HY-132198
需求量：