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  2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Propargyl-PEG4-Br

Propargyl-PEG4-Br 是一種 PROTAC 連接橋，屬于 PEG 類。Propargyl-PEG4-Br 可用于合成一系列 PROTAC 分子。Propargyl-PEG4-Br 是一種不可降解 (non-cleavable) 的 ADC 連接橋，用于抗體活性分子結(jié)合物 (ADCs) 的合成。Propargyl-PEG4-Br 是一種點擊化學試劑。它含有 Alkyne 基團，可以和含有 Azide 基團的分子發(fā)生銅催化的疊氮-炔環(huán)加成反應 (CuAAc)。

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Propargyl-PEG4-Br Chemical Structure

Propargyl-PEG4-Br Chemical Structure

CAS No. : 1308299-09-3

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規(guī)格 價格 是否有貨 數(shù)量
100 mg ￥200
In-stock
250 mg ￥324
In-stock
1 g ￥808
詢價
5 g ￥2825
詢價
10 g   詢價  
50 g   詢價  

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG4-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

Non-cleavable Linker

 

PEGs

 

體外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

295.17

Formula

C11H19BrO4
CAS 號
性狀

液體（密度：1.269±0.06 g/cm3）

顏色

Light yellow to yellow

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: ≥95.0%

參考文獻

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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  • Do most proteins show cross-species activity?

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產(chǎn)品名稱：
Propargyl-PEG4-Br
目錄號：
HY-130591
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