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  2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. FIPI

FIPI  (Synonyms: 5-Fluoro-2-indolyl deschlorohalopemide)

目錄號(hào): HY-12807 純度: 99.82%
COA 產(chǎn)品使用指南 技術(shù)支持

FIPI 是一種磷脂酶 D (PLD) 抑制劑，對(duì) PLD1 和 PLD2 的 IC50 約為 25 nM。FIPI 可調(diào)節(jié)細(xì)胞骨架重組、細(xì)胞擴(kuò)散和趨化性等過程。FIPI 可用于腫瘤的研究。此外，F(xiàn)IPI 能夠增強(qiáng)血小板致密顆粒的分泌和聚集，抑制血栓形成、減小缺血性中風(fēng)梗死體積和改善神經(jīng)功能。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

FIPI Chemical Structure

FIPI Chemical Structure

CAS No. : 939055-18-2

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥935
In-stock
5 mg ￥850
In-stock
10 mg ￥1100
In-stock
50 mg ￥3500
In-stock
100 mg ￥5500
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

Other Forms of FIPI:

    FIPI purchased from MCE. Usage Cited in: Anal Chem. 2018 Jun 5;90(11):6742-6748.  [Abstract]

    Typical CSLM images of MDA-MB-231 cells incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C in the absence (I) and presence of 1.0 mg/mL FIPI (II), and CSLM images of MCF-7 cells (III) incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C.

    FIPI purchased from MCE. Usage Cited in: J Cell Sci. 2018 Mar 16;131(6). pii: jcs207217.  [Abstract]

    ER:Ras IMR90 cells are treated with solvent or FIPI (250 nM, 2h).Western blotting are performed.

    查看 Phospholipase 亞型特異性產(chǎn)品:

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    FIPI is a phospholipase D (PLD) inhibitor with an IC50 for PLD1 and PLD2 of about 25 nM. FIPI regulates cytoskeletal recombination, cell diffusion and chemotaxis. FIPI can be used in cancer research. In addition, FIPI can enhance the secretion and aggregation of platelet dense particles, inhibit thrombosis, reduce ischemic stroke infarct volume and improve nerve function[1][2][3][4].

    IC50 & Target[1]

    PLD1

     

    PLD2

     

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    Calu-1 IC50
    1 nM
    Compound: 14
    Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
    Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
    		[PMID: 19136975]
    HEK293 IC50
    300 nM
    Compound: 14
    Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
    Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
    		[PMID: 19136975]
    體外研究
    (In Vitro)

    FIPI (750 nM；30 分鐘) 在 HEK293 細(xì)胞中，能有效阻斷 PMA (HY-18739) 刺激的 PLD 產(chǎn)生磷脂酸[1]。
    FIPI (750 nM；1-4 小時(shí)) 可促進(jìn) CHO 細(xì)胞的擴(kuò)散和抑制中性粒細(xì)胞的趨化[1]。
    FIPI (1-100 nM；1-45 分鐘) 在 EGF 誘導(dǎo)的 MDA-MB-468-NEO (EGFR 陽性) 和 MDA-MB-468-HER2 (EGFR 和HER2 陽性) 中抑制細(xì)胞遷移和鈣釋放[2]。
    FIPI (10 μM；2.5 分鐘) 可增強(qiáng)血小板中致密顆粒的分泌和聚集，增加蛋白激酶 C 底物 Pleckstrin 的磷酸化[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    FIPI (3 mg/kg；腹腔注射；兩次) 在頸動(dòng)脈血栓模型和缺血性中風(fēng)模型中具有保護(hù)作用[4]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Ferric chloride (HY-Y0266) or transient middle cerebral artery occlusion treated mice[4]
    Dosage: 3 mg/kg
    Administration: Intraperitoneal injection (i.p.); 2 times, 12 h apart
    Result: Delayed the thrombus formation and only 3 of 9 vessels occluded during the 30-minute observation period in arterial thrombosis models.
    Reduced the infarct volumes, improved motor and overall nerve function and did not impair normal hemostasis in ischemic stroke models.
    分子量

    421.47

    Formula

    C23H24FN5O2
    CAS 號(hào)
    性狀

    固體

    顏色

    Light yellow to khaki

    中文名稱

    5-氟-2-吲哚基脫氯鹵培米特
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 14.67 mg/mL (34.81 mM; 超聲加熱助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 2.3726 mL 11.8632 mL 23.7265 mL
    5 mM 0.4745 mL 2.3726 mL 4.7453 mL
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物溶解方案計(jì)算器
    請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    純度 & 產(chǎn)品資料

    純度: 99.82%

    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3726 mL 11.8632 mL 23.7265 mL 59.3162 mL
    5 mM 0.4745 mL 2.3726 mL 4.7453 mL 11.8632 mL
    10 mM 0.2373 mL 1.1863 mL 2.3726 mL 5.9316 mL
    15 mM 0.1582 mL 0.7909 mL 1.5818 mL 3.9544 mL
    20 mM 0.1186 mL 0.5932 mL 1.1863 mL 2.9658 mL
    25 mM 0.0949 mL 0.4745 mL 0.9491 mL 2.3726 mL
    30 mM 0.0791 mL 0.3954 mL 0.7909 mL 1.9772 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱：
    FIPI
    目錄號(hào)：
    HY-12807
    需求量：