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  2. Anti-infection
  3. Parasite
  4. Primaquine diphosphate

Primaquine diphosphate  (Synonyms: 磷酸伯氨喹; Primaquine phosphate; Primaquine bisphosphate)

目錄號: HY-12651 純度: 99.28%
COA 產(chǎn)品使用指南 技術支持

Primaquine diphosphate 是一種有效的抗瘧疾劑，也是一種有效的惡性瘧原蟲殺配子體。Primaquine diphosphate 可防止間日瘧和卵形瘧復發(fā)。

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Primaquine diphosphate Chemical Structure

Primaquine diphosphate Chemical Structure

CAS No. : 63-45-6

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥550
In-stock
500 mg ￥494
In-stock
1 g ￥800
In-stock
5 g ￥1140
In-stock
10 g ￥1900
In-stock
50 g   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Primaquine diphosphate:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Primaquine diphosphate is a potent antimalaria agent and a potent gametocytocide in falciparum malaria. Primaquine diphosphate prevents relapse in vivax and ovale malaria[1].

IC50 & Target

Plasmodium

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
5 μM
Compound: PQ diphosphate
Cytotoxicity against human A2780 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 29407988]
CAPAN-1 IC50
14.24 μM
Compound: PQ diphosphate
Cytotoxicity against human Capan1 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human Capan1 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 29407988]
HCT-116 IC50
13.99 μM
Compound: PQ
Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTT assay
[PMID: 31431364]
HCT-116 IC50
44.22 μM
Compound: PQ diphosphate
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 29407988]
HEK293 IC50
10.96 μM
Compound: PQ
Antiproliferative activity against human HEK293 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human HEK293 cells measured after 72 hrs by MTT assay
[PMID: 31431364]
HL-60 IC50
11.36 μM
Compound: PQ diphosphate
Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 29407988]
K562 IC50
12.04 μM
Compound: PQ diphosphate
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 29407988]
L6 IC50
27.1 μg/mL
Compound: PQ diphsophate
Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue-based assay
Cytotoxicity against rat L6 cells after 70 hrs by Alamar Blue-based assay
[PMID: 29220797]
L6 IC50
59.5 μM
Compound: PQ diphosphate
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by Alamar blue assay
Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 70 hrs by Alamar blue assay
[PMID: 29407988]
MCF7 IC50
5 μM
Compound: PQ diphosphate
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 29407988]
MCF7 IC50
8.73 μM
Compound: PQ
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay
[PMID: 31431364]
NCI-H460 IC50
10 μM
Compound: PQ diphosphate
Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 29407988]
NCI-H460 IC50
19.84 μM
Compound: PQ
Antiproliferative activity against human H460 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human H460 cells measured after 72 hrs by MTT assay
[PMID: 31431364]
SW-620 IC50
14 μM
Compound: PQ diphosphate
Cytotoxicity against human SW620 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human SW620 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 29407988]
體外研究
(In Vitro)

Primaquine diphosphate 顯著降低活乳腺癌細胞的增殖，對 MCF-7 (ER+) 和 MDA-MB-453 (HER2+) 細胞的增殖沒有抑制作用。Primaquine diphosphate 在體外抑制乳腺癌細胞的生長、遷移和集落形成[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: MDA-MB-231, HCC1937 cells, MCF-7, and MDA-MB-453 cells
Concentration: 5 μM, 10 μM, 20 μM, 40 μM, 80 μM, 100 μM, 120 μM, and 150 μM
Incubation Time: 24 hours
Result: Decreases breast cancer cell viability.
體內研究
(In Vivo)

Primaquine（5-25 mg/kg；口服；每日；持續(xù) 3 天）diphosphate 沒有顯示肝臟生物發(fā)光信號，也沒有血液階段寄生蟲血癥[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male 6-week-old C57BL/6 albino mice with sporozoite inoculation[2]
Dosage: 5 mg/kg, 10 mg/kg, 15 mg/kg, 20 mg/kg, and 25 mg/kg
Administration: p.o; daily; for 3 days
Result: No blood stage parasitaemia was observed.
Clinical Trial
分子量

455.34

Formula

C15H27N3O9P2
CAS 號
性狀

固體

顏色

Orange to reddish brown

中文名稱

磷酸伯氨喹；磷酸伯氨喹啉；磷酸伯喹；撲瘧喹；磷酸普奈馬喹；二磷酸普奈馬奎
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 250 mg/mL (549.04 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

H2O 中的溶解度 : 25 mg/mL (54.90 mM; 超聲助溶 (<60°C))

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 2.1962 mL 10.9808 mL 21.9616 mL
5 mM 0.4392 mL 2.1962 mL 4.3923 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

請根據(jù)您的 實驗動物和給藥方式 選擇適當?shù)娜芙夥桨浮?

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 方案 一

    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (4.57 mM); 澄清溶液

    此方案可獲得 ≥ 2.08 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 20.8 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

    生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
  • 方案 二

    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (4.57 mM); 澄清溶液

    此方案可獲得 ≥ 2.08 mg/mL（飽和度未知）的澄清溶液。

    以 1 mL 工作液為例，取 100 μL 20.8 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

    2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。

以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑： PBS

    Solubility: 50 mg/mL (109.81 mM); 澄清溶液; 超聲助溶

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.28%

參考文獻

Primaquine diphosphate 相關分類

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.1962 mL 10.9808 mL 21.9616 mL 54.9040 mL
5 mM 0.4392 mL 2.1962 mL 4.3923 mL 10.9808 mL
10 mM 0.2196 mL 1.0981 mL 2.1962 mL 5.4904 mL
15 mM 0.1464 mL 0.7321 mL 1.4641 mL 3.6603 mL
20 mM 0.1098 mL 0.5490 mL 1.0981 mL 2.7452 mL
25 mM 0.0878 mL 0.4392 mL 0.8785 mL 2.1962 mL
30 mM 0.0732 mL 0.3660 mL 0.7321 mL 1.8301 mL
40 mM 0.0549 mL 0.2745 mL 0.5490 mL 1.3726 mL
50 mM 0.0439 mL 0.2196 mL 0.4392 mL 1.0981 mL
DMSO 60 mM 0.0366 mL 0.1830 mL 0.3660 mL 0.9151 mL
80 mM 0.0275 mL 0.1373 mL 0.2745 mL 0.6863 mL
100 mM 0.0220 mL 0.1098 mL 0.2196 mL 0.5490 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

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產(chǎn)品名稱：
Primaquine diphosphate
目錄號：
HY-12651
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