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  2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Berberrubine chloride

Berberrubine chloride  (Synonyms: 小檗紅堿)

目錄號(hào): HY-125850 純度: 99.28%
COA 產(chǎn)品使用指南

Berberrubine chloride 是黃連素的有效代謝物，可降低動(dòng)物模型中潰瘍性結(jié)腸炎的癥狀。

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Berberrubine chloride Chemical Structure

Berberrubine chloride Chemical Structure

CAS No. : 15401-69-1

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥171
In-stock
5 mg ￥350
In-stock
10 mg ￥520
In-stock
25 mg ￥950
In-stock
50 mg ￥1450
In-stock
100 mg ￥2150
In-stock
200 mg   詢(xún)價(jià)  
500 mg   詢(xún)價(jià)  

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Customer Review

Other Forms of Berberrubine chloride:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Berberrubine chloride is an active metabolite of berberine, attenuates ulcerative colitis in mice model[1].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
Bel-7402 IC50
34.31 μM
Compound: 2, Berberrubine
Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
10.1007/s00044-013-0796-9
BGC-823 IC50
7.66 μM
Compound: 2, Berberrubine
Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
10.1007/s00044-013-0796-9
CCRF-CEM CC50
169.2 μM
Compound: 5
Cytotoxicity against human CEM cells expressing green fluorescent protein after 48 hrs by MTT assay
Cytotoxicity against human CEM cells expressing green fluorescent protein after 48 hrs by MTT assay
[PMID: 21295891]
CCRF-CEM EC50
2.8 μM
Compound: 5
Antiviral activity against 0.05 MOI Human immunodeficiency virus 1 NL4.3 infected in human CEM cells expressing green fluorescent protein assessed as p24 antigen production measured 7 days post infection by ELISA
Antiviral activity against 0.05 MOI Human immunodeficiency virus 1 NL4.3 infected in human CEM cells expressing green fluorescent protein assessed as p24 antigen production measured 7 days post infection by ELISA
[PMID: 21295891]
HepG2 IC50
> 50 μM
Compound: 2, Berberrubine
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
[PMID: 23182088]
HepG2 IC50
> 50 μM
Compound: 2, Berberrubine
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 23182088]
HL-60 IC50
11.36 μM
Compound: 2, Berberrubine
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
10.1007/s00044-013-0796-9
HT-29 IC50
> 50 μM
Compound: 2, Berberrubine
Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay
[PMID: 23182088]
HT-29 IC50
36.93 μM
Compound: 2, Berberrubine
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 23182088]
KB IC50
6.92 μM
Compound: 2, Berberrubine
Cytotoxicity against human KB cells after 48 hrs by MTT assay
Cytotoxicity against human KB cells after 48 hrs by MTT assay
10.1007/s00044-013-0796-9
分子量

357.79

Formula

C19H16ClNO4
CAS 號(hào)
性狀

固體

顏色

Yellow to reddish brown

中文名稱(chēng)

小檗紅堿
結(jié)構(gòu)分類(lèi)
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 5 mg/mL (13.97 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

Ethanol 中的溶解度 : 2 mg/mL (5.59 mM; 超聲助溶)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.7949 mL 13.9747 mL 27.9494 mL
5 mM 0.5590 mL 2.7949 mL 5.5899 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶。

  • 方案 一

    請(qǐng)依序添加每種溶劑： 0.5% CMC-Na/saline water

    Solubility: 5 mg/mL (13.97 mM); 懸濁液; 超聲助溶

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.28%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.7949 mL 13.9747 mL 27.9494 mL 69.8734 mL
5 mM 0.5590 mL 2.7949 mL 5.5899 mL 13.9747 mL
DMSO 10 mM 0.2795 mL 1.3975 mL 2.7949 mL 6.9873 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
Berberrubine chloride
目錄號(hào)：
HY-125850
需求量：