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  2. Anti-infection
  3. Influenza Virus
  4. 2,3-Dehydro-2-deoxy-N-acetylneuraminic acid

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid  (Synonyms: Neu5Ac2en; DANA)

目錄號(hào): HY-125798 純度: ≥98.0%
COA 產(chǎn)品使用指南 技術(shù)支持

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) 是一種有效的神經(jīng)氨酸酶 (neuraminidase) 抑制劑。N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid 對(duì)人 neuraminidase 酶具有抑制活性，對(duì)人 NEU1、NEU2、NEU3 和 NEU4 的 IC50 值分別為 143、43、61 和 74 μM。N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid 具有抗流感病毒活性。

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2,3-Dehydro-2-deoxy-N-acetylneuraminic acid Chemical Structure

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid Chemical Structure

CAS No. : 24967-27-9

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MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity[1][2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
168 μM
Compound: NeuAc2en
Inhibition of human NEU1 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate
Inhibition of human NEU1 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate
[PMID: 18694948]
HEK293 IC50
45.5 μM
Compound: NeuAc2en
Inhibition of human NEU2 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate
Inhibition of human NEU2 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate
[PMID: 18694948]
HEK293 IC50
70.3 μM
Compound: NeuAc2en
Inhibition of human NEU3 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using ganglioside GM3 substrate
Inhibition of human NEU3 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using ganglioside GM3 substrate
[PMID: 18694948]
HEK293 IC50
73.1 μM
Compound: NeuAc2en
Inhibition of human NEU4 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate
Inhibition of human NEU4 expressed in HEK293 cells by fluorometric high-performance liquid chromatography using 4MU-NeuAc substrate
[PMID: 18694948]
HEK-293T IC50
0.04 mM
Compound: 2, Neu5Ac2en, DANA
Inhibition of human NEU2 transiently transfected in HEK293T cells by fluorimetric analysis
Inhibition of human NEU2 transiently transfected in HEK293T cells by fluorimetric analysis
[PMID: 19450982]
HEK-293T IC50
0.06 mM
Compound: 2, Neu5Ac2en, DANA
Inhibition of human NEU3 transiently transfected in HEK293T cells by fluorimetric high-performance liquid chromatography
Inhibition of human NEU3 transiently transfected in HEK293T cells by fluorimetric high-performance liquid chromatography
[PMID: 19450982]
HEK-293T IC50
0.07 mM
Compound: 2, Neu5Ac2en, DANA
Inhibition of human NEU4 transiently transfected in HEK293T cells by fluorimetric analysis
Inhibition of human NEU4 transiently transfected in HEK293T cells by fluorimetric analysis
[PMID: 19450982]
HEK-293T IC50
0.143 mM
Compound: 2, Neu5Ac2en, DANA
Inhibition of human NEU1 transiently transfected in HEK293T cells by fluorimetric analysis
Inhibition of human NEU1 transiently transfected in HEK293T cells by fluorimetric analysis
[PMID: 19450982]
HEK-293T IC50
49 μM
Compound: 1; DANA
Inhibition of human CathA-IRES-6His-tagged NEU1 expressed in HEK293T cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay
Inhibition of human CathA-IRES-6His-tagged NEU1 expressed in HEK293T cells using 4MU-NANA as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by fluorescence based assay
[PMID: 29425031]
HEK-293T IC50
50 μM
Compound: 2; DANA
Inhibition of human Neu3 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis
Inhibition of human Neu3 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis
[PMID: 27095056]
HEK-293T IC50
50 μM
Compound: 2; DANA
Inhibition of human Neu2 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis
Inhibition of human Neu2 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis
[PMID: 27095056]
HEK-293T IC50
50 μM
Compound: 2; DANA
Inhibition of human Neu1 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis
Inhibition of human Neu1 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis
[PMID: 27095056]
HEK-293T IC50
50 μM
Compound: 2; DANA
Inhibition of human Neu4 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis
Inhibition of human Neu4 expressed in HEK293T cells using 4MU-Neu5Ac as substrate incubated for 30 mins by HPLC analysis
[PMID: 27095056]
HEK-293T IC50
50 μM
Compound: 2; DANA
Inhibition of human Neu4 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis
Inhibition of human Neu4 expressed in HEK293T cells using GM3 as substrate incubated for 30 mins by HPLC analysis
[PMID: 27095056]
體外研究
(In Vitro)

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10-100 μM) 顯著抑制 INS-1D 細(xì)胞中的唾液酸酶活性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10-100 μM) 顯著抑制 INS-1D 細(xì)胞中的唾液酸酶活性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (Mouse model of pulmonary fibrosis)[3]
Dosage: 10?mg/kg
Administration: I.p.; daily (starting at day 10 after Bleomycin, and then euthanized at day 21)
Result: Inhibition of sialidases starting at day 10 after bleomycin attenuates fibrosis.
Clinical Trial
分子量

291.25

Formula

C11H17NO8
CAS 號(hào)
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

H2O 中的溶解度 : 33.33 mg/mL (114.44 mM; 超聲助溶)

DMSO 中的溶解度 : 1 mg/mL (3.43 mM; 超聲加熱助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.4335 mL 17.1674 mL 34.3348 mL
5 mM 0.6867 mL 3.4335 mL 6.8670 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲(chǔ)備液濃度超過該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: ≥99.0%

參考文獻(xiàn)

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid 相關(guān)分類

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.4335 mL 17.1674 mL 34.3348 mL 85.8369 mL
H2O 5 mM 0.6867 mL 3.4335 mL 6.8670 mL 17.1674 mL
10 mM 0.3433 mL 1.7167 mL 3.4335 mL 8.5837 mL
15 mM 0.2289 mL 1.1445 mL 2.2890 mL 5.7225 mL
20 mM 0.1717 mL 0.8584 mL 1.7167 mL 4.2918 mL
25 mM 0.1373 mL 0.6867 mL 1.3734 mL 3.4335 mL
30 mM 0.1144 mL 0.5722 mL 1.1445 mL 2.8612 mL
40 mM 0.0858 mL 0.4292 mL 0.8584 mL 2.1459 mL
50 mM 0.0687 mL 0.3433 mL 0.6867 mL 1.7167 mL
60 mM 0.0572 mL 0.2861 mL 0.5722 mL 1.4306 mL
80 mM 0.0429 mL 0.2146 mL 0.4292 mL 1.0730 mL
100 mM 0.0343 mL 0.1717 mL 0.3433 mL 0.8584 mL

* 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
2,3-Dehydro-2-deoxy-N-acetylneuraminic acid
目錄號(hào)：
HY-125798
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