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  1. Anti-infection
  2. Bacterial Parasite HCV
  3. Micrococcin P1

Micrococcin P1  (Synonyms: 微球菌素 P1)

目錄號(hào): HY-125728 純度: ≥95.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Micrococcin P1 是一種大環(huán)肽抗生素,是一種有效的丙型肝炎病毒 (HCV) 抑制劑,EC50 范圍為 0.1-0.5 μM。Micrococcin P1 對(duì)革蘭氏陽(yáng)性細(xì)菌菌株具有體外抗菌活性,對(duì)金黃色葡萄球菌 1974149 菌株,糞腸球菌 1674621 菌株和化膿性鏈球菌 1744264 菌株的 MIC 值分別為 2 μg/ mL,1 μg/ mL 和 1 μg/ mL。Micrococcin P1 還是瘧疾寄生蟲惡性瘧原蟲的有效抑制劑。

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Micrococcin P1 Chemical Structure

Micrococcin P1 Chemical Structure

CAS No. : 67401-56-3

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規(guī)格 價(jià)格 是否有貨 數(shù)量
500 μg ¥6400
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM[1]. Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively[2]. Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum[3].

IC50 & Target

HCV[1]; Bacterial[2]; Parasite[3]

體外研究
(In Vitro)

Dose-response assays reveales Micrococcin P1 to be very potent with a minimal inhibitory concentration (MIC) of 32-63 nM. Cytotoxicity assays reveales no significant impairment on cell line growth (<10% inhibition at 30 mM) over a 40 h period for both the hepatic cell line HepG2 and the monocytic cell line THP-1, leading to a selectivity index greater than 500. Also investigats the intracellular activity of Micrococcin P1, it is active against GFP-expressing M. tuberculosis H37Rv growing inside RAW 264.7 macrophages with an IC80 of about 1 mM with potency comparable with that of isoniazid[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1144.37

Formula

C48H49N13O9S6

CAS 號(hào)
性狀

固體

顏色

White to yellow

中文名稱

微球菌素 P1

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: ≥95.0%

參考文獻(xiàn)

Micrococcin P1 相關(guān)分類

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱:
Micrococcin P1
目錄號(hào):
HY-125728
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